Searching for miRNA as a biomarker in blood colorectal cancer in blood to evaluate sensitivities against chemotherapies for colorectal cancer

• Project/Area Number: 15K10035
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Juntendo University
• Principal Investigator: TAKAHSHI Makoto 順天堂大学, 医学部, 准教授 (40445549)
• Co-Investigator(Kenkyū-buntansha): 小見山 博光 順天堂大学, 医学部, 非常勤講師 (30348982) ; 加藤 俊介 順天堂大学, 医学(系)研究科(研究院), 教授 (40312657) ; 茂櫛 薫 順天堂大学, 医学(系)研究科(研究院), 非常勤講師 (60569292)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 腫瘍マーカー / 抗がん剤感受性 / 大腸がん / マイクロRNA / 血中RNA / CAGE解析 / microRNA / 治療効果判定 / 腫瘍メーカー / 大腸癌 / リキッドバイオプシー

Outline of Final Research Achievements

To identify microRNA in blood, as a tumor marker of colon cancer,　 we analyzed comparison before and after the treatment adaptation of the same patient with microarray analysis using blood samples We used stored samples of cases in a particular stage and pathophysiological status selected from a considerable number of colorectal cancer cases in our hospital. A microRNA detected a significantly higher level of expression in blood before surgery than that after surgery. To verify its efficiency as a diagnostic marker and a therapeutic effects marker, the level of this miRNA in blood before and after surgery or chemotherapy and also those in various stages of cases are analyzing.

Academic Significance and Societal Importance of the Research Achievements

長らく抗がん剤治療の有効率が他の癌に比べると低かった大腸がんであったが，近年，抗腫瘍効果の高い分子標的薬の開発により飛躍的に治療選択肢が増えた。しかし既存のCEAや　CA19-9，p53抗体などの大腸がんマーカーでも採血のみでがんを診断することは難しく早期診断は困難である。したがって,様々な抗がん剤を含む幅広い選択肢から最適な治療選択を行うための指標となる高い診断力を持ったマーカーの新規開発が望まれる。本研究では採血サンプルから早期を含む大腸がんの検出が可能な新規マーカーmiRNAを同定した。今後の研究進展によって採血による大腸がん早期診断,また治療効果判定への臨床応用が期待できる。

Research Products

• [Journal Article] Histological characteristics of eosinophilic myenteric ganglionitis: an under-recognised cause of chronic intestinal pseudo-obstruction. (2019)
  • Author(s): Akazawa Y, Hayashi T, Saito T, Niwa K, Kamiyama H, Sasahara N, Sakamoto K, Nagahara A, Yao T.
  • Journal Title: Virchows Archiv Volume: 474(3) Issue: 3 Pages: 395-400
  • DOI: 10.1007/s00428-018-02513-5
  • Peer Reviewed
• [Journal Article] Noninvasive local correction of loop ileostomy prolapse using a stapling device for a patient in the terminal phase of malignancy. (2019)
  • Author(s): Kojima Y, Sakamoto K, Kawai M, Mizukoshi K.
  • Journal Title: Journal of Surgical Case Reports Volume: 2019(3) Issue: 3
  • DOI: 10.1093/jscr/rjz050
  • Peer Reviewed / Open Access
• [Journal Article] The Association between Absence of Abdominal Pain and Mortality in Lower Intestinal Perforation in Patients with Autoimmune Rheumatic Diseases. (2019)
  • Author(s): Endo Y, Abe Y, Kawano S, Ando T, Sakamoto K, Tamura N.
  • Journal Title: BioMed Research International Volume: 2019:5381453 Pages: 1-8
  • DOI: 10.1155/2019/5381453
  • Peer Reviewed / Open Access
• [Journal Article] DNA methylation genome-wide analysis in remnant and primary gastric cancers. (2019)
  • Author(s): Sugimoto K, Ito T, Hulbert A, Chen C, Orita H, Maeda M, Moro H, Fukagawa T, Ushijima T, Katai H, Wada R, Sato K, Sakamoto K, Yu W, Considine M, Cope L, Brock MV.
  • Journal Title: Gastric Cancer Volume: 2019 Issue: 6 Pages: 1109-1120
  • DOI: 10.1007/s10120-019-00949-5
  • NAID: 40022051036
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Endoscopic Submucosal Dissection Decreases Additional Colorectal Resection for T1 Colorectal Cancer. (2018)
  • Author(s): Tomiki Y, Kawai M, Kawano S, Ishiyama S, Sugimoto K, Takahashi M, Kojima Y, Murakami T, Ritsuno H, Shibuya T, Sakamoto N, Sakamoto K.
  • Journal Title: Medical Science Monitor Volume: 24 Pages: 6910-6917
  • DOI: 10.12659/msm.909380
  • Peer Reviewed
• [Journal Article] Rectal neuroendocrine tumours treated using endoscopic submucosal dissection with myectomy - a video vignette. (2018)
  • Author(s): Honjo K, Kure K, Ro H, Mizukoshi K, Kawai M, Ishiyama S, Takahashi M, Tomiki Y, Sakamoto K.
  • Journal Title: Colorectal Disease Volume: 20(11) Issue: 11 Pages: 1055-1056
  • DOI: 10.1111/codi.14418
  • Peer Reviewed
• [Journal Article] High-sensitivity detection of micrometastases generated by GFP lentivirus-transduced organoids cultured from a patient-derived colon tumor. (2018)
  • Author(s): OkazawaY, Mizukoshi K, KoyamaY, Okubo S, Komiyama H, Kojima Y, Goto M, Habu S, Hino O, Sakamoto K, Orimo A.
  • Journal Title: J Vis Exp Volume: 136(e57374) Issue: 136 Pages: 463-473
  • DOI: 10.3791/57374
  • Peer Reviewed / Open Access
• [Journal Article] Survival benefit of lymph node dissection in surgery for colon cancer in elderly patients:multicenter propensity score-matched study in Japan. (2018)
  • Author(s): Takahashi M, Niitsu H, Sakamoto K, Hinoi T, Hattori M, Goto M, Bando H, Hazama S, Maeda K, Okita K, Horie H, Watanabe M; Japan Society of Laparoscopic Colorectal Surgery.
  • Journal Title: Asian J Endosc Surg Volume: 2018 Mar 30 Issue: 4 Pages: 1-9
  • DOI: 10.1111/ases.12474
  • Peer Reviewed
• [Journal Article] Surgical technique and outcomes of transabdominal preperitoneal inguinal hernia repair after radical prostatectomy: dissection between the transversalis fascia and superficial layers of preperitoneal fascia. (2018)
  • Author(s): Ohuchi M, Fukunaga M, Nagakari K, Azuma D, Kohama S, Nomoto J, Sakamoto K.
  • Journal Title: Hernia Volume: 23(1) Issue: 1 Pages: 167-174
  • DOI: 10.1007/s10029-018-1800-6
  • Peer Reviewed
• [Journal Article] Impact of Left Colonic Artery Preservation on Anastomotic Leakage in Laparoscopic Sigmoid Resection and Anterior Resection for Sigmoid and Rectosigmoid Colon Cancer. (2018)
  • Author(s): Kato H, Munakata S, Sakamoto K, Sugimoto K, Yamamoto R, Ueda S, Tokuda S, Sakuraba S, Kushida T, Orita H, Sakurada M, Maekawa H, Sato K.
  • Journal Title: Journal of Gastrointestinal Cancer Volume: 2018 Issue: 4 Pages: 1-5
  • DOI: 10.1007/s12029-018-0126-z
  • Peer Reviewed
• [Journal Article] Pharmacological targeting of neutrophil serine proteases prevents lethality in dextran sulfate sodium (DSS)-induced colitis in mice (2018)
  • Author(s): Ro H, Munakata S, Ueyama T, Komiyama H, Takahashi M, Kojima Y, Tomiki Y, Sakamoto K
  • Journal Title: Journal of Gastrointestinal & Digestive System Volume: 8 Issue: 01 Pages: 551-551
  • DOI: 10.4172/2161-069x.1000551
  • Peer Reviewed / Open Access
• [Journal Article] Neutrophil-lymphocyte ratio as a prognostic factor in incurable stage IV colorectal cancer. (2018)
  • Author(s): Munakata S, Sugimoto K, Honjo K, Kawai M, Kawano S, Kamiyama H, Ouchi M, Takahashi M, Tomiki Y, Sakamoto K.
  • Journal Title: Open Journal of Gastroenterology Volume: 8(02) Issue: 02 Pages: 45-56
  • DOI: 10.4236/ojgas.2018.82005
  • Peer Reviewed / Open Access
• [Journal Article] Identification and characterization of a novel <i>adenomatous polyposis coli</i> mutation in adult pancreatoblastoma (2018)
  • Author(s): Yamaguchi S, Fujii T, Izumi Y, Fukumura Y, Han M, Yamaguchi H, Akita T, Yamashita C, Kato S, Sekiya T.
  • Journal Title: Oncotarget Volume: 9(12) Issue: 12 Pages: 10818-10827
  • DOI: 10.18632/oncotarget.24017
  • Peer Reviewed / Open Access
• [Journal Article] Molecular and clinical features of the TP53 signature gene expression profile in early-stage breast cancer. (2018)
  • Author(s): Yamaguchi S, Takahashi S, Mogushi K, Izumi Y, Nozaki Y, Nomizu T, Kakugawa Y, Ishida T, Ohuchi N, Ishioka C, Kato S.
  • Journal Title: Oncotarget Volume: 9(18) Issue: 18 Pages: 14193-14206
  • DOI: 10.18632/oncotarget.24447
  • Peer Reviewed / Open Access
• [Journal Article] Propensity Score Analysis in the Comparison of Long-Term Outcomes for Locally Advanced Colon Cancer Between Laparoscopic Colectomy and Open Colectomy (2017)
  • Author(s): Sugimoto K, Sakamoto K, Ichikawa R, Kure K, Honjo K, Ro H, Takahashi R, Kawano, Niwa K, Ishiyama S, Kamiyama H, Komiyama H, Takahashi M, Kojima Y, Goto M, Okuzawa A, Ishibiki Y, Tomiki Y
  • Journal Title: Juntendo Medical Journal Volume: 63 Issue: 4 Pages: 264-272
  • DOI: 10.14789/jmj.63.264
  • NAID: 130006106309
  • ISSN: 2187-9737, 2188-2126
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Salivary Chromogranin A as a Psychosomatic Stress Marker Is Suppressed in Laparoscopic Surgery Compared with Open Surgery for Colon Cancer (2017)
  • Author(s): Ishiyama S, Sakamoto K, Kamiyama H, Niwa K, Sugimoto K, Takahashi M, KojimaY, Goto M, Okuzawa A, Tomiki Y:
  • Journal Title: Juntendo Medical Journal Volume: 63 Issue: 2 Pages: 88-94
  • DOI: 10.14789/jmj.63.88
  • NAID: 130006944480
  • ISSN: 2187-9737, 2188-2126
  • Peer Reviewed / Open Access
• [Journal Article] Minimally Invasive Surgery for Colorectal Cancer (2017)
  • Author(s): Sakamoto K, Tsukamoto R, Kawano S, Kawai M, Niwa K, Ishiyama S, Sugimoto K, Kamiyama H, Komiyama H, Takahashi M, Kojima Y, Goto M, Okuzawa A, Tomiki Y:
  • Journal Title: Juntendo Medical Journal Volume: 63 Issue: 5 Pages: 384-392
  • DOI: 10.14789/jmj.63.384
  • NAID: 130006219695
  • ISSN: 2187-9737, 2188-2126
  • Peer Reviewed / Open Access
• [Journal Article] ARID2 modulates DNA damage response in human hepatocellular carcinoma cells. (2017)
  • Author(s): Oba A, Shimada S, Akiyama Y, Nishikawaji T, Mogushi K, Ito H, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Asahara H, Kaida A, Miura M, Tanabe M, Tanaka S.
  • Journal Title: Journal of Hepatology Volume: in press Issue: 5 Pages: 942-951
  • DOI: 10.1016/j.jhep.2016.12.026
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Correlation of EGFR or KRAS mutation status with 18F-FDG uptake on PET-CT scan in lung adenocarcinoma. (2017)
  • Author(s): Takamochi K, Mogushi K, Kawaji H, Imashimizu K, Fukui M, Oh S, Itoh M, Hayashizaki Y, Ko W, Akeboshi M, Suzuki K.
  • Journal Title: PLoS One Volume: 12(4):e0175622. Issue: 4 Pages: e0175622-e0175622
  • DOI: 10.1371/journal.pone.0175622
  • Peer Reviewed / Open Access
• [Journal Article] Salivary chromogranin a as a psychosomatic stress marker is suppressed in laparoscopic surgery compared with open surgery for colon cancer (2017)
  • Author(s): Ishiyama S, Sakamoto K, Kamiyama H, Niwa K, Sugimoto K, Takahashi M, Kojima Y, Goto M, Okuzawa A, Tomiki
  • Journal Title: Juntendo Medical Journal Volume: 63 Pages: 1-7
  • NAID: 130006944480
  • Peer Reviewed / Open Access
• [Journal Article] Postoperative Adjuvant Chemotherapy Improves Survival in Stage II Colon Cancer ? A Propensity Score Matching Analysis (2016)
  • Author(s): Sugimoto K, Sakamoto K, Niwa K, Ishiyama S Kamiyama H, Komiyama H, Takahashi M,Kojima Y, Goto M, Tomiki Y:
  • Journal Title: Juntendo Medical Journal Volume: 62 Issue: 6 Pages: 463-471
  • DOI: 10.14789/jmj.62.463
  • NAID: 130005402125
  • ISSN: 2187-9737, 2188-2126
  • Peer Reviewed / Open Access
• [Journal Article] An impact of Chromosome 17q deletion in the primary lesion of colorectal cancer on liver metastasis, (2016)
  • Author(s): Kawai M, Komiyama H, Hosoya M, Okubo H, Fujii T, Yokoyama N, Sato C, Ueyama T, Okuzawa A, Goto M, Kojima Y, Takahashi M, Sugimoto K, Ishiyama S, Munakata S, Ogura D, Niwa S, Tomiki Y, Ochiai T, Sakamoto K
  • Journal Title: Oncology Letters Volume: 12(6) Pages: 4773-4778
  • Peer Reviewed / Open Access
• [Journal Article] Unusual False-Positive Mesenteric Lymph Nodes Detected by PET/CT in a Metastatic Survey of Lung Cancer. (2016)
  • Author(s): Kamiyama H, Sakamoto K, Niwa K, Ishiyama S, Takahashi M, Kojima Y, Goto M, Tomiki Y, Nakamichi I, Oh S, Suzuki K.
  • Journal Title: Case Rep Gastroenterol. Volume: 10(2) Pages: 275-82
• [Journal Article] Tailor-Made Medicine for Colorectal Cancer (2016)
  • Author(s): Takahashi M, Sakamoto K
  • Journal Title: Juntendo Medical Journal Volume: 62 Issue: 4 Pages: 13-16
  • DOI: 10.1111/ases.12293
  • NAID: 130005151655
  • Peer Reviewed / Open Access
• [Journal Article] The Analysis of Prognosis by Data Mining Using the Decision Tree Analysis in Stage Ⅲ Colon and Rectosigmoid Cancer (2016)
  • Author(s): 杉本 起一・丹羽浩一郎・石山 隼 神山 博彦・小見山博光・高橋 玄・小島 豊・五藤 倫敏・冨木 裕一・坂本 一博
  • Journal Title: Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons) Volume: 41 Issue: 1 Pages: 1-7
  • DOI: 10.4030/jjcs.41.1
  • NAID: 130005397845
  • ISSN: 0385-7883, 1882-9112
  • Peer Reviewed / Open Access
• [Journal Article] StageIII結腸・直腸S状部癌における決定期分析を用いたデータマイニングによる予後解析 (2016)
  • Author(s): 杉本起一，丹羽浩一郎，石山 隼，神山博彦，小見山博光，高橋 玄，小島 豊，五藤倫敏，冨木裕一，坂本一博
  • Journal Title: 日本外科系連合学会雑誌 Volume: 41 Pages: 0000-0000
  • Peer Reviewed
• [Journal Article] CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells. (2016)
  • Author(s): Katsuta, E., Tanaka, S., Mogushi, K., Shimada, S., Akiyama, Y., Aihara, A., Matsumura, S., Mitsunori, Y., Ban, D., Ochiai, T., Kudo, A., Fukamachi, H., Tanaka, H., Nakayama, K., Arii, S., Tanabe, M.
  • Journal Title: Int. J. Oncol. Volume: 48 Issue: 2 Pages: 657-669
  • DOI: 10.3892/ijo.2015.3299
  • Peer Reviewed / Open Access
• [Journal Article] Impact of chromosome 17q deletion in the primary lesion of colorectal cancer on liver metastasis (2016)
  • Author(s): Kawai M, Komiyama H, Hosoya M, Okubo H, Fujii T, Yokoyama N, Sato C, Ueyama T, Okuzawa A, Goto M, Kojima Y, Takahashi M, Sugimoto K, Ishiyama S, Munakata S, Ogura D, Niwa S, Tomiki Y, Ochiai T, Sakamoto K
  • Journal Title: ONCOLOGY LETTERS Volume: 11 Pages: 00-00
  • Peer Reviewed
• [Journal Article] Overexpression of the S100A2 protein as a prognostic marker for patients with stage II and III colorectal cancer. (2016)
  • Author(s): Masuda T, Ishikawa T, Mogushi K, Okazaki S, Ishiguro M, Iida S, Mizushima H, Tanaka H, Uetake H, Sugihara K.
  • Journal Title: Int J Oncol. 2016 Mar;48(3):975-82.. Volume: 48(3) Issue: 3 Pages: 975-982
  • DOI: 10.3892/ijo.2016.3329
  • Peer Reviewed / Open Access
• [Journal Article] A mutation spectrum that includes GNAS, KRAS and TP53 may be shared by mucinous neoplasms of the appendix. (2015)
  • Author(s): Hara K, Saito T, Hayashi T, Yimit A, Takahashi M, Mitani K, Takahashi M, Yao T
  • Journal Title: Pathology - Research and Practice Volume: 211(9) Issue: 9 Pages: 657-664
  • DOI: 10.1016/j.prp.2015.06.004
  • Peer Reviewed
• [Journal Article] Loss of MyD88 alters neuroinflammatory response and attenuates early Purkinje cell loss in a spinocerebellar ataxia type 6 mouse model (2015)
  • Author(s): Aikawa T, Mogushi K, Iijima-Tsutsui K, Ishikawa K, Sakurai H, Tanaka H, Mizusawa H, Watase K
  • Journal Title: Human molecular genetics Volume: 24（17） Issue: 17 Pages: 4780-4791
  • DOI: 10.1093/hmg/ddv202
  • Peer Reviewed / Open Access
• [Journal Article] 骨転移診療ガイドライン―薬物治療について (2015)
  • Author(s): 山口 茂夫, 影山 俊一郎, 三浦 佳代, 加藤 俊介
  • Journal Title: 癌と化学療法 Volume: 42(11) Pages: 1342-1345
• [Presentation] Laparoscopic Para-Aortic Lymph Node Resection For Colorectal Cancer. (2018)
  • Author(s): Kazuhiro Sakamoto,Toshiaki Hagiwara, Hirokazu Matsuzawa, Shingo Kawano, Shinya Kawai, Koichiro Niwa, Shun Ishiyama, Kiichi Sugimoto, Hirohiko Kamiyama, Makoto Takahashi, Yutaka Kojima, Yuichi Tomiki, Tetsu Fukunaga, Yoshiaki Kajiyama, Seiji Kawasaki
  • Organizer: SAGES & CAGES 16TH WORLD CONGRESS OF ENDOSCOPIC SURGERY, Seattle, WA, USA
  • Int'l Joint Research
• [Presentation] Complete Mesocolic Excision For Transverse Colon In Our Hospital. (2018)
  • Author(s): Shun Ishiyama, Kota Amemiya, Yuki Tsuchiya, Hirokazu Matsuzawa, Shingo Kawano, Masaya Kawai, Koichiro Niwa, Kiichi Sugimoto, Hirohiko Kamiyama, Makoto Takahashi, Hiromitsu Komiyama, Yutaka Kojima, Atsushi Okuzawa, Yuichi Tomiki, Tetsu Fukunaga, Yoshiaki Kajiyama, Seiji Kawasaki, Kazuhiro Sakamoto
  • Organizer: SAGES & CAGES 16TH WORLD CONGRESS OF ENDOSCOPIC SURGERY, Seattle, WA, USA
  • Int'l Joint Research
• [Presentation] A Study On Rectum Cancer Surgery Using Needlescopic Instruments. (2018)
  • Author(s): Toshiaki Hagiwara, Yuki Tsuchiya, Shunsuke Motegi, Ryoichi Tsukamoto, Shingo Ito, Shingo Kawano, Shun Ishiyama, Kiichi Sugimoto, Makoto Takahashi, Yutaka Kojima, Tetsu Fukunaga, Yoshiaki Kajiyama, Seiji Kawasaki, Kazuhiro Sakamoto
  • Organizer: SAGES & CAGES 16TH WORLD CONGRESS OF ENDOSCOPIC SURGERY, Seattle, WA, USA
  • Int'l Joint Research
• [Presentation] Experience Of Using A Spray-Type Anti-Adhesion Barrier In Laparoscopic Surgery For Colorectal Carcinoma. (2018)
  • Author(s): Yutaka Kojima, Kazuhiro Sakamoto, Yuichi Tomiki, Michitoshi Goto, Makoto Takahashi, Hirohiko Kamiyama, Kiichi Sugimoto, Shun Ishiyama, Koichiro Niwa, Masaya Kawai, Ryoichi Tsukamoto, Shunsuke Motegi, Yurika Makino, Toshiaki Hagiwara, Seiji Kawasaki, Yoshiaki Kajiyama, Tetsu Fukunaga
  • Organizer: SAGES & CAGES 16TH WORLD CONGRESS OF ENDOSCOPIC SURGERY, Seattle, WA, USA
  • Int'l Joint Research
• [Presentation] The Feasibility Of Laparoscopic Surgery For Primary Tumor Resection In Patients With Metastatic Colorectal Cancer. (2018)
  • Author(s): Shingo Ito, Kazuhiro Sakamoto, Ryo Ohta, Yuki Tsuchiya, Hirokazu Matsuzawa, Ryoichi Tsukamoto, Shinya Munakata, Masaya Kawai, Koichiro Niwa, Shun Ishiyama, Kiichi Sugimoto, Hirohiko Kamiyama, Makoto Takahashi, Yutaka Kojima, Yuichi Tomiki
  • Organizer: SAGES & CAGES 16TH WORLD CONGRESS OF ENDOSCOPIC SURGERY, Seattle, WA, USA
  • Int'l Joint Research
• [Presentation] Survival Benefit of Lymph Node Dissection in Surgery for Colon Cancer in Elderly Patients: A Multicenter Propensity Score-matched Case-control Study in Japan (2018)
  • Author(s): M. Takahashi, H. Niitsu, K. Sakamoto, T. Hinoi, M. Hattori, M. Goto, H. Horie, M. Watanabe
  • Organizer: ASCRS 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] Short-term Outcomes of Laparoscopic Mutivisceral Resection for Locally Advanced Colon Cancer (2018)
  • Author(s): K. Sakamoto, S. Kawano, M. Kawai, K. Niwa, S. Ishiyama, K. Sugimoto, H. Kamiyama, M. Takahashi, Y. Kojima, Y. Tomiki
  • Organizer: ASCRS 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] Laparoscopic natural orifice specimen extraction using needlescopic instruments for colon cancer (2018)
  • Author(s): Kazuhiro Sakamoto, Hirokazu Matsuzawa, Yu Okazawa, Rina Takahashi, Kosuke Mizukoshi, Kiichi Sugimoto, Makoto Takahashi, Yutaka Kojima
  • Organizer: The 29th ISUCRS Biennial Congress
  • Int'l Joint Research
• [Presentation] The Significance of Plasma p14 gene DNA Methylation in Colorectal Cancer (2018)
  • Author(s): Hirokazu Matsuzawa, Kichi Sugimoto, Shun Ishiyama, Hirohiko Kamiyama, Makoto Takahashi, Yutaka Kojima, Yuichi Tomiki and Kazuhiro Sakamoto.
  • Organizer: The 29th ISUCRS Biennial Congress
  • Int'l Joint Research
• [Presentation] Prognostic Factor For Locally Advanced Rectal Cancer After Surgery Following Chemoradiotherapy: Which Factor Is More Important To Predict The Long-term Outcome? (2018)
  • Author(s): Kosuke Mizukoshi, Hirokazu Matsuzawa, Masaya Kawai, Kiichi Sugimoto, Hiromitsu Komiyama, Yutaka Kojima, Yuichi Tomiki, Kazuhiro Sakamoto.
  • Organizer: The 29th ISUCRS Biennial Congress
  • Int'l Joint Research
• [Presentation] The Combination of TAS-102 and Bevacizumab as the third line chemotherapy for metastatic colorectal cancer (TAS-CC3 Study) (2018)
  • Author(s): H. Kamiyama, Y. Yoshida, H. Yoshida, C. Kosugi, K. Ishibashi, K. Ihara, M. Takahashi, H. Kuramochi, A. Fukazawa, H. Sonoda, K. Yoshimatsu, A. Matsuda, S. Yamaguchi, H. Ishida, S. Hasegawa, T. Yamada, K. Sakamoto, K. Koda
  • Organizer: ESMO 2018 Congress
  • Int'l Joint Research
• [Presentation] 大腸癌における血漿中遊離DNAのCHFR遺伝子メチル化測定の意義(英語) (2018)
  • Author(s): 杉本 起一, 牧野 有里香, 青木 順, 岡澤 裕, 水越 幸輔, 河合 雅也, 宗像 慎也, 石山 隼, 神山 博彦, 高橋 玄, 小島 豊, 冨木 裕一, 福永 哲, 梶山 美明, 坂本 一博
  • Organizer: 第56回日本癌治療学会学術集会
• [Presentation] SLC7A1に対するモノクローナル抗体 大腸癌組織における遺伝子発現評価と,抗体の癌細胞株に対する傷害活性(Monoclonal antibodies against SLC7A1: assessment of gene expression and cytotoxicity in colorectal cancer) (2018)
  • Author(s): 深谷 緑, 小見山 博光, 杉本 起一, 神山 博彦, 益子 高, 坂本 一博
  • Organizer: 第77回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] 胃がんのゲノム・エピゲノム異常 残胃癌におけるゲノムワイドDNAメチル化解析(Genetic and epigenetic aberrations in gastric cancer DNA Methylation Genome-Wide Analysis in Remnant Gastric Cancer) (2018)
  • Author(s): 杉本 起一, 伊藤 智彰, 折田 創, 佐藤 浩一, 前田 将宏, 茂呂 浩史, 牛島 俊和, 片井 均, 和田 了, 坂本 一博, Brock Malcolm V.
  • Organizer: 第77回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] 大腸癌における循環血液中p14遺伝子DNAメチル化測定の意義 (2018)
  • Author(s): 杉本 起一, 萩原 俊昭, 神山 博彦, 高橋 玄, 小島 豊, 冨木 裕一, 福永 哲, 梶山 美明, 川崎 誠治, 坂本 一博
  • Organizer: 第73回日本消化器外科学会総会
• [Presentation] 網羅的解析を用いた新規結腸癌診断マーカーの探索 (2018)
  • Author(s): 塚本 亮一, 小見山 博光, 細谷 理樹, 河野 眞吾, 河合 雅也, 高橋 玄, 小島 豊, 冨木 裕一, 坂本 一博
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] Semaphorin 3C has a possibility of a new prognostic marker in colorectal cancer. (2017)
  • Author(s): Kawano S, Komiyama H, Takahashi M, Sakamoto K et al
  • Organizer: 110th AACR, Washington DC,
  • Int'l Joint Research
• [Presentation] Postoperative adjuvant chemotherapy improves survival in stage II colon cancer ? a propensity score matching analysis. (2017)
  • Author(s): Tsukamoto R, Takahashi M, Sakamoto K et al.
  • Organizer: 110th AACR, Washington DC,
  • Int'l Joint Research
• [Presentation] Production of monoclonal antibodies against amino acid transporter SLC7A1 to develop novel therapy for colorectal cancer. (2017)
  • Author(s): Fukaya M, Komiyama H, Sugimoto K, Kamiyama H, Sakamoto K:
  • Organizer: 第76回日本癌学会学術総会, 横浜
• [Presentation] Identification of a novel diagnostic marker for colon cancer through comprehensive microRNA analysis. (2017)
  • Author(s): Tsukamoto R, Komiyama H, Hosoya M, Kure K, Okazawa Y, Mizukoshi K, Fukaya M, Sugimoto K, Kamiyama H, Tomiki Y, Sakamoto K:
  • Organizer: 第76回日本癌学会学術総会 横浜
• [Presentation] 当科における進行直腸癌に対する 術前化学放射線療法の検討 (2016)
  • Author(s): 呉 一眞，牧野有里香，茂木俊介，塚本亮一，伊藤慎吾，市川亮介, 本庄薫平，盧 尚志，髙橋里奈, 河野眞吾, 宗像慎也,丹羽浩一郎，石山 隼, 杉本起一，神山博彦，髙橋 玄，小島 豊, 五藤倫敏, 冨木裕一, 坂本一博
  • Organizer: 第24回日本消化器関連学会週間
  • Place of Presentation: 神戸コンベンションセンター，兵庫県神戸市
  • Year and Date: 2016-11-05
• [Presentation] 当科における High Risk StageⅡ結腸癌 についての検討 (2016)
  • Author(s): 塚本亮一 茂木俊介 市川亮介 髙橋里奈 水越幸輔 嵩原一裕 神山博彦 髙橋 玄 小島 豊 坂本一博
  • Organizer: 第78回日本臨床外科学会総会
  • Place of Presentation: グランドプリンスホテル新高輪，東京都港区
• [Presentation] Our Strategies for Recruitment for Gastroenterological Surgery (2016)
  • Author(s): 小島 豊，丹羽浩一郎，石山 隼，杉本起一，神山博彦，高橋 玄
  • Organizer: 第71回日本消化器外科学会総会
  • Place of Presentation: アスティとくしま，徳島県徳島市
• [Presentation] The detection of colorectal CTC by the use of polymeric microfluidic devices. (2015)
  • Author(s): 呉一眞，細谷理樹，小見山博光，冨木裕一，落合 匠，大永崇，坂本一博
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] Patient-derived colon carcinoma cells disseminate into distant organs in various different fashions. (2015)
  • Author(s): Okazawa Y, Mizukoshi K, Komiyama H, Fujii T, Goto M, Hino O, Sakamoto K, Orimo A.
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] Metastatic seeding of patient-derived colon cancer cells maintaining epithelial or mesenchymal trait. (2015)
  • Author(s): 水越 幸輔，岡澤 裕 ，門脇奈穂美，小見山博光，小島 豊，五藤 倫敏，垣生 園子，樋野 興夫，折茂 彰 ，坂本 一博
  • Organizer: 第70回日本消化器外科学会総会
  • Place of Presentation: 浜松
  • Year and Date: 2015-07-15
• [Presentation] Comparisons of long-term outcomes for locally advanced colon cancer between laparoscopic colectomy and open colectomy; propensity score analysis. (2015)
  • Author(s): Sugimoto K, Sakamoto K, Tomiki Y, Goto M, Kojima Y, Komiyama H, Takahashi M, Kamiyama H, Ishiyama S, Niwa K, Ito S, Kawai M, Takehara K, Tashiro T, Munakata S, Aoki J, Okazawa Yu O, Takahashi R, Mizukoshi K, Ro H, Ichikawa R, Kure K, Honjyo K, Tsukamoto R.
  • Organizer: 23th International Congress of the EAES
  • Place of Presentation: Bucharest, Romania
  • Year and Date: 2015-06-03
  • Int'l Joint Research
• [Presentation] CHFR methylation is an independent prognostic marker of poor prognosis in gastric cancer. (2015)
  • Author(s): Sugimoto K, Humbert A, Lu Z, Chen C, Rodgers K, Lee B, Griffin C, Sato K, Orita H, Ito T, Komiyama H, Kojima Y, Goto M, Tomiki Y, Sakamoto K, Brock M
  • Organizer: 2015 American Association for Cancer Research Annual Meeting
  • Place of Presentation: Pennsylvania, USA
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] Polymeric CTC-chipを用いた大腸癌CTCの検出. (2015)
  • Author(s): 呉 一眞, 細谷 理樹, 塚本 亮一, 伊藤 慎吾, 本庄 薫平, 岡澤 裕, 水越 幸輔, 宗像 慎也, 石山 隼, 杉本 起一, 神山 博彦, 小見山 博光, 高橋 玄, 柳沼 行宏, 小島 豊, 五藤 倫敏, 奥澤 淳司, 冨木 裕一, 坂本 一博, 大永 崇
  • Organizer: 第11６回日本外科学会定期学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-14
• [Remarks] 順天堂大学大学院 下部消化管外科学
  • URL: https://www.juntendo.ac.jp/graduate/laboratory/labo/kabusyoukakan/
• [Remarks] 順天堂大学 下部消化管外科
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/kabusyoukakan/