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Photodynamic therapy using nanoparticle loaded with indocyanine green for experimental peritoneal dissemination of gastric cancer

Research Project

Project/Area Number 15K10042
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionNational Defense Medical College

Principal Investigator

Tsujimoto Hironori  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 医療安全・感染対策部, 教授 (80554998)

Co-Investigator(Kenkyū-buntansha) 守本 祐司  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 分子生体制御学, 准教授 (10449069)
宮崎 裕美  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 防衛医学研究センター 外傷研究部門, 助教 (30531636)
平木 修一  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 外科学, 助教 (40638839)
青笹 季文  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 外科学, 准教授 (40649034)
木下 学  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 免疫・微生物学, 准教授 (70531391)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords胃がん / 腹膜播種 / 光線力学療法 / 動物実験 / 胃癌 / リンパ節転移
Outline of Final Research Achievements

Clinical applicants have experimented with photodynamic therapy for sentinel lymph node metastasis and peritoneal dissemination in mice. However, in vivo experiments on peritoneal dissemination in mice was limited, and it was impossible to investigate using laparoscopy in view of the clinical application of this study. In this study, we demonstrated the feasibility of photodynamic therapy to disseminated lesion using rat laparoscopic system for rat peritoneal dissemination model.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 2015

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Invited: 1 results)

  • [Journal Article] Thermal sensor circuit using thermography for temperature-controlled laser hyperthermia2017

    • Author(s)
      Nomura S, Arake M, Morimoto Y, Tsujimoto H, Miyazaki H, Saitoh D, Shinomiya N, Hase K, Yamamoto J, Ueno H
    • Journal Title

      Journal of Sensors

      Volume: 1 Pages: 1-7

    • Related Report
      2017 Annual Research Report
  • [Journal Article] In vivo evaluation of a modified linear stapling device designed to facilitate accurate pathologic examination of the surgical margin2016

    • Author(s)
      Hironori Tsujimoto
    • Journal Title

      Gastric Cance

      Volume: 19 Pages: 666-669

    • NAID

      40020836472

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Theranostic photosensitive nanoparticles for lymph node metastasis of gastric cancer2016

    • Author(s)
      Hironori Tsujimoto
    • Journal Title

      Annals of Surgical Oncology

      Volume: in print Issue: S3 Pages: 000-000

    • DOI

      10.1245/s10434-015-4594-0

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Photodynamic therapy using nanoparticle for murine experimental peritoneal dissemination of gastric cancer2017

    • Author(s)
      Shinsuke Nomura
    • Organizer
      第89回日本胃癌学会
    • Place of Presentation
      広島
    • Year and Date
      2017-03-08
    • Related Report
      2016 Research-status Report
  • [Presentation] A novel theranostic tool for gastric cancer using ICG lactosome and near infrared laser2017

    • Author(s)
      Shinsuke Nomura1, Yuji Morimoto2, Hironori Tsujimoto1, Risa Takahata1, Hiroyuki Horiguchi1, Hiromi Miyazaki3, Daizo Saito3, Isao Hara4, Eiichi Ozeki4, Kazuo Hase1, Junji Yamamoto1, and Hideki Ueno1
    • Organizer
      第76回日本癌学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新しい腹膜播種治療戦略~インドシアニングリーン内包生分解性ナノ粒子を用いた光温熱療法~2017

    • Author(s)
      野村信介、辻本広紀、上野秀樹
    • Organizer
      第15回日本消化器外科学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ドラッグデリバリーシステム型インドシアニングリーンによる光温熱効果に関する検討2017

    • Author(s)
      野村信介1、守本祐司2、辻本広紀1、小関英一3、原功3、矢口義久1、平木修一1、長谷和生1、山本順司1、上野秀樹1
    • Organizer
      第27回日本光線力学学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ICG内包生分解性ナノ粒子を用いた光温熱療法による臨床応用展開の可能性2017

    • Author(s)
      野村信介,守本祐司,辻本広紀,平木修一,菅澤英一,高畑りさ,堀口寛之,原功*3,小関英一*3,斉藤大蔵*2,四ノ宮成祥*,長谷和生,山本順司,上野秀樹
    • Organizer
      第117回日本外科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ICG内包生分解性ナノミセルを用いた光線力学療法によるhyperthermiaの影響2016

    • Author(s)
      野村信介
    • Organizer
      第54回日本癌治療学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-20
    • Related Report
      2016 Research-status Report
  • [Presentation] ナノ粒子を用いた胃癌腹膜播種診断と光線力学療法2016

    • Author(s)
      野村信介
    • Organizer
      第71回日本消化器外科学会
    • Place of Presentation
      徳島
    • Year and Date
      2016-07-15
    • Related Report
      2016 Research-status Report
  • [Presentation] ナノ粒子を用いた胃癌腹膜播種診断と光線力学療法2015

    • Author(s)
      辻本広紀
    • Organizer
      第70回日本消化器外科学会
    • Place of Presentation
      浜松
    • Year and Date
      2015-07-15
    • Related Report
      2015 Research-status Report
  • [Presentation] Photodynamic therapy using nanoparticle loaded with indocyanine green for experimental peritoneal dissemination of gastric cancer2015

    • Author(s)
      辻本広紀
    • Organizer
      第54回日本生体医工学会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-05-04
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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