| Project/Area Number |
15K10045
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
Watanabe Gou 東北大学, 大学病院, 講師 (70451573)
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| Co-Investigator(Kenkyū-buntansha) |
伊藤 正敏 東北大学, サイクロトロン・ラジオアイソトープセンター, 名誉教授 (00125501)
石田 孝宣 東北大学, 医学系研究科, 教授 (00292318)
渡部 浩司 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (40280820)
大内 憲明 東北大学, 医学系研究科, 客員教授 (90203710)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Keywords | 乳癌 / 乳房温存手術 / PEM / ナビゲーション手術 / 医療者被ばく / １８F-FDG / 被ばく / 小型PEM / 担癌マウス |
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| Outline of Final Research Achievements |
18F-FDG accumulation of resected specimens in breast-conserving surgery was evaluated with high resolution Positron Emission Mammography (PEM). In 16 cases, the invasive cancer lesion was detectable at 100% (12/12) and the noninvasive cancer lesion was detectable at 94.4% (17/18), and the medical staff exposure was as low as 18 μSV on average. The simulation was carried out when 2 cm margin was removed from the range of PEM accumulation, the amount of resection could be reduced by 58% without additional margin positive cases.
Furthermore, we have developed a highly sensitive thin and compact PEM using silicon photomultiplier, which makes it possible to detect 18 F-FDG in the operative field. It was able to separate 1.4 mm spaced pixels.
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