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The establishment of breast navigation surgery using Si-PM based intraoperative PET system

Research Project

Project/Area Number 15K10045
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionTohoku University

Principal Investigator

Watanabe Gou  東北大学, 大学病院, 講師 (70451573)

Co-Investigator(Kenkyū-buntansha) 伊藤 正敏  東北大学, サイクロトロン・ラジオアイソトープセンター, 名誉教授 (00125501)
石田 孝宣  東北大学, 医学系研究科, 教授 (00292318)
渡部 浩司  東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (40280820)
大内 憲明  東北大学, 医学系研究科, 客員教授 (90203710)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywords乳癌 / 乳房温存手術 / PEM / ナビゲーション手術 / 医療者被ばく / 18F-FDG / 被ばく / 小型PEM / 担癌マウス
Outline of Final Research Achievements

18F-FDG accumulation of resected specimens in breast-conserving surgery was evaluated with high resolution Positron Emission Mammography (PEM). In 16 cases, the invasive cancer lesion was detectable at 100% (12/12) and the noninvasive cancer lesion was detectable at 94.4% (17/18), and the medical staff exposure was as low as 18 μSV on average. The simulation was carried out when 2 cm margin was removed from the range of PEM accumulation, the amount of resection could be reduced by 58% without additional margin positive cases.
Furthermore, we have developed a highly sensitive thin and compact PEM using silicon photomultiplier, which makes it possible to detect 18 F-FDG in the operative field. It was able to separate 1.4 mm spaced pixels.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] 18F-fluorodeoxyglucose specimen-positron emission mammography delineates tumour extension in breast-conserving surgery: Preliminary results.2018

    • Author(s)
      Watanabe G, Itoh M, Duan X, Watabe H, Mori N, Tada H, Suzuki A, Miyashita M, Ohuchi N, Ishida T.
    • Journal Title

      European Radiology

      Volume: 28 Issue: 5 Pages: 1929-1937

    • DOI

      10.1007/s00330-017-5170-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Development of a Si-PM based intraoperative PET system for breast tumor resection.2017

    • Author(s)
      Watabe, H
    • Organizer
      IEEE Nuclear Science Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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