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Serum carnitine kinetics by administration of fat emulsion at the perioperative period and effect of intravenous administration of L-carnitine

Research Project

Project/Area Number 15K10047
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionNiigata University

Principal Investigator

Koyama Yu  新潟大学, 医歯学系, 教授 (10323966)

Co-Investigator(Kenkyū-buntansha) 諸 和樹  新潟大学, 医歯学総合病院, 特任助教 (10745566)
永橋 昌幸  新潟大学, 医歯学総合病院, 講師 (30743918)
若井 俊文  新潟大学, 医歯学系, 教授 (50372470)
三浦 宏平  新潟大学, 医歯学総合病院, 助教 (70733658)
小杉 伸一  新潟大学, 医歯学総合病院, 特任教授 (90401736)
小林 隆  新潟大学, 医歯学総合病院, その他 (40464010)
Co-Investigator(Renkei-kenkyūsha) KOMATSU Masaaki  新潟大学, 医歯学系, 教授 (90356254)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsカルニチン / 静脈栄養 / 脂肪乳剤 / 術後回復 / CRP / 経腸栄養 / 乳び胸 / 低脂肪経腸栄養剤 / タンパク代謝 / インスリン抵抗性 / Rapid turnover protein / 末梢静脈栄養 / RTP / RBP
Outline of Final Research Achievements

Lipid, one of the essential nutrients for intravenous nutrition and enteral nutrition, can enhance early recovery of the patients under stress condition such as surgery, if appropriately used. In postoperative parenteral nutrition, administration of L-carnitine in addition to lipid emulsion significantly reduced CRP, an inflammatory response substance, on postoperative days 3 to 7. Therefore, administration of L-carnitine in addition to lipid emulsion may be effective for withdrawing from the inflammatory response after surgery.
In enteral nutrition, early enteral nutrition using low fat-containing elemental formula after esophagectomy with three-field lymphadenectomy is useful for early recovery and prevention of chylous leak.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Intravenous Carnitine Administration in Addition to Parenteral Nutrition with Lipid Emulsion may Decrease the Inflammatory Reaction in Postoperative Surgical Patients.2017

    • Author(s)
      KoyamaY, Moro K, Nakano M, Miura K, Nagahashi M, Kosugi S-I, Tsuchida J, Ikarashi M, Nakajima M, Ichikawa H, Hanyu T, Shimada Y, Jun Sakata J, Kameyama H, Kobayashi T, Wakai T.
    • Journal Title

      Journal of Clinical Medicine Research

      Volume: 9 Issue: 10 Pages: 831-837

    • DOI

      10.14740/jocmr3113w

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low fat-containing elemental formula is effective for postoperative recovery and potentially useful for preventing chyle leak during postoperative early enteral nutrition after esophagectomy.2016

    • Author(s)
      Moro K, Koyama Y, Kosugi SI, Ishikawa T, Ichikawa H, Hanyu T, Miura K, Nagahashi M, Nakajima M, Tatsuda K, Tsuchida J, Toshikawa C, Ikarashi M, Shimada Y, Sakata J, Kobayashi T, Kameyama H, Wakai T
    • Journal Title

      Clinical Nutrition

      Volume: 35 Issue: 6 Pages: 1423-1428

    • DOI

      10.1016/j.clnu.2016.03.018

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 周術期末梢静脈栄養:脂肪乳剤投与におけるカルニチン併用による炎症反応の軽減効果2017

    • Author(s)
      諸 和樹、小山 諭、永橋昌幸、三浦宏平、土田純子、中島真人、若井俊文1
    • Organizer
      第54回日本外科代謝栄養学会
    • Place of Presentation
      朱鷺メッセ 新潟コンベンションセンター(新潟県新潟市)
    • Year and Date
      2017-07-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Validity of adding intravenous carnitine to parenteral nutrition with lipid emulsion for deceasing inflammatory reaction of postoperative surgical patients.2017

    • Author(s)
      Koyama Y, Moro K, Miura K, Nagahashi M, Kosugi S-I, Tsuchida J, Ikarashi M, Nakajima M, Ichikawa H, Shimada Y, Kameyama H, Kobayashi T, Wakai T
    • Organizer
      39th ESPEN
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 周術期末梢静脈栄養 脂肪乳剤投与におけるカルニチン併用による炎症反応の軽減効果.2017

    • Author(s)
      諸 和樹, 小山 諭, 永橋 昌幸, 三浦 宏平, 土田 純子, 中島 真人, 若井 俊文.
    • Organizer
      第54回日本外科代謝栄養学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 周術期末梢静脈栄養における脂肪乳剤とカルニチン投与の検討2016

    • Author(s)
      小山 諭、諸 和樹、永橋昌幸、三浦宏平、辰田久美子、土田純子、中島真人、若井俊文
    • Organizer
      第53回日本外科代謝栄養学会
    • Place of Presentation
      伊藤国際学術研究センター(東京都文京区)
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 周術期末梢静脈栄養における脂肪乳剤とカルニチン投与の検討2016

    • Author(s)
      小山 諭
    • Organizer
      日本外科代謝栄養学会第53回学術集会
    • Place of Presentation
      東京大学伊藤国際学術研究センター( 文京区・東京都)
    • Year and Date
      2016-07-07
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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