Serum carnitine kinetics by administration of fat emulsion at the perioperative period and effect of intravenous administration of L-carnitine
Project/Area Number |
15K10047
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General surgery
|
Research Institution | Niigata University |
Principal Investigator |
Koyama Yu 新潟大学, 医歯学系, 教授 (10323966)
|
Co-Investigator(Kenkyū-buntansha) |
諸 和樹 新潟大学, 医歯学総合病院, 特任助教 (10745566)
永橋 昌幸 新潟大学, 医歯学総合病院, 講師 (30743918)
若井 俊文 新潟大学, 医歯学系, 教授 (50372470)
三浦 宏平 新潟大学, 医歯学総合病院, 助教 (70733658)
小杉 伸一 新潟大学, 医歯学総合病院, 特任教授 (90401736)
小林 隆 新潟大学, 医歯学総合病院, その他 (40464010)
|
Co-Investigator(Renkei-kenkyūsha) |
KOMATSU Masaaki 新潟大学, 医歯学系, 教授 (90356254)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | カルニチン / 静脈栄養 / 脂肪乳剤 / 術後回復 / CRP / 経腸栄養 / 乳び胸 / 低脂肪経腸栄養剤 / タンパク代謝 / インスリン抵抗性 / Rapid turnover protein / 末梢静脈栄養 / RTP / RBP |
Outline of Final Research Achievements |
Lipid, one of the essential nutrients for intravenous nutrition and enteral nutrition, can enhance early recovery of the patients under stress condition such as surgery, if appropriately used. In postoperative parenteral nutrition, administration of L-carnitine in addition to lipid emulsion significantly reduced CRP, an inflammatory response substance, on postoperative days 3 to 7. Therefore, administration of L-carnitine in addition to lipid emulsion may be effective for withdrawing from the inflammatory response after surgery. In enteral nutrition, early enteral nutrition using low fat-containing elemental formula after esophagectomy with three-field lymphadenectomy is useful for early recovery and prevention of chylous leak.
|
Report
(4 results)
Research Products
(7 results)
-
[Journal Article] Intravenous Carnitine Administration in Addition to Parenteral Nutrition with Lipid Emulsion may Decrease the Inflammatory Reaction in Postoperative Surgical Patients.2017
Author(s)
KoyamaY, Moro K, Nakano M, Miura K, Nagahashi M, Kosugi S-I, Tsuchida J, Ikarashi M, Nakajima M, Ichikawa H, Hanyu T, Shimada Y, Jun Sakata J, Kameyama H, Kobayashi T, Wakai T.
-
Journal Title
Journal of Clinical Medicine Research
Volume: 9
Issue: 10
Pages: 831-837
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Low fat-containing elemental formula is effective for postoperative recovery and potentially useful for preventing chyle leak during postoperative early enteral nutrition after esophagectomy.2016
Author(s)
Moro K, Koyama Y, Kosugi SI, Ishikawa T, Ichikawa H, Hanyu T, Miura K, Nagahashi M, Nakajima M, Tatsuda K, Tsuchida J, Toshikawa C, Ikarashi M, Shimada Y, Sakata J, Kobayashi T, Kameyama H, Wakai T
-
Journal Title
Clinical Nutrition
Volume: 35
Issue: 6
Pages: 1423-1428
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
[Presentation] Validity of adding intravenous carnitine to parenteral nutrition with lipid emulsion for deceasing inflammatory reaction of postoperative surgical patients.2017
Author(s)
Koyama Y, Moro K, Miura K, Nagahashi M, Kosugi S-I, Tsuchida J, Ikarashi M, Nakajima M, Ichikawa H, Shimada Y, Kameyama H, Kobayashi T, Wakai T
Organizer
39th ESPEN
Related Report
Int'l Joint Research
-
-
-