Analysis of the mechanism of augmentation of random migration in lymphocytes and verification of the significance as a biomarker predicting therapeutic effect of immunotherapy
| Project/Area Number |
15K10055
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大西 秀哉 九州大学, 医学研究院, 准教授 (30553276)
久保 真 九州大学, 大学病院, 講師 (60403961)
今泉 晃 九州大学, 医学研究院, 共同研究員 (30624051)
山崎 章生 九州大学, 医学研究院, 共同研究員 (80404440)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 活性化リンパ球 / リンパ球運動能 / 免疫療法 / バイオマーカー / 治療効果予測 / 細胞傷害活性 / リンパ球増殖能 / 癌浸潤リンパ球 / 運動能 / 増殖能 / 癌免疫療法 / 細胞障害活性 / ランダムマイグレーション / 免疫細胞療法 |
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| Outline of Final Research Achievements |
We detected molecule X as a factor that contributes to the random migration in activated lymphocytes by microarray analysis. Expression of molecule X is increased through the activation process. Inhibition of molecule X in activated lymphocytes increased random migration, proliferation and cytotoxicity (in vitro and in vivo). These results suggest that molecule X may act as a biomarker predicting therapeutic effect of immunotherapy and target molecule improving therapeutic effect of immunotherapy.
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Report
(4 results)
Research Products
(21 results)
