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The development of detection of cancer cells with gGlu-HMRG and clinical application

Research Project

Project/Area Number 15K10056
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionKagoshima University

Principal Investigator

SHINDEN Yoshiaki  鹿児島大学, 附属病院, 医員 (20725733)

Co-Investigator(Kenkyū-buntansha) 三森 功士  九州大学, 大学病院, 教授 (50322748)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords癌細胞可視化
Outline of Final Research Achievements

1) Improvement of condition for clinical application; The detection sensitivity of existing equipment is low, and it turned out that there is a limit to the amount of specimen that can be measured at one time. We undertook a business tie-up, and aimed ① improvement of the optical system, ② reconsideration the equipment design for measuring a large number of specimens at the same time ③ developing software which can judge and display the fluorescence positive area. Currently we are accumulating cases and developing equipment.
2) Discovering the genetic mechanism of GGT expression; Samples which are necessary for analysis have not been obtained due to 1). We are studying the relationship between the expression of GGT protein and the effect of cancer radiotherapy and the expression with protein related to oxidative stress.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2015

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Rapid intraoperative visualization of breast lesions with γ-glutamyl hydroxymethyl rhodamine green2015

    • Author(s)
      H.Ueo, Y.Shinden et al.
    • Journal Title

      Scientific Reports

      Volume: 5:12080 Issue: 1 Pages: 1-6

    • DOI

      10.1038/srep12080

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] The new technique of detecting breast cancer cells using new fluorescent probe ‘gGlu-HMRG’2015

    • Author(s)
      新田吉陽ら
    • Organizer
      日本がん転移学会
    • Place of Presentation
      シティプラザ大阪(大阪府大阪市)
    • Year and Date
      2015-07-23
    • Related Report
      2015 Research-status Report
  • [Presentation] 乳腺腫瘍を可視化する新規蛍光物質「gGlu-HMRG」を用いた乳癌の術中断端病理診断への応用2015

    • Author(s)
      新田吉陽ら
    • Organizer
      日本乳癌学会総会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2015-07-03
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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