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Ectopic expression of MECA-79 in breast cancer

Research Project

Project/Area Number 15K10058
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionFukushima Medical University

Principal Investigator

Abe Noriko  福島県立医科大学, 医学部, 講師 (30622336)

Co-Investigator(Kenkyū-buntansha) 岡山 洋和  福島県立医科大学, 医学部, 助教 (20583397)
大竹 徹  福島県立医科大学, 医学部, 教授 (50363750)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords乳癌 / 糖鎖
Outline of Final Research Achievements

We previously reported that a carbohydrate determinant, MECA-79, is ectopically expressed in gastric cancer, and is associated with clinical outcomes. The present study attempted to focus on the clinical and functional implication of MECA-79 expression in breast cancer, using breast cancer specimens and breast cancer cell lines, mainly by immunohistochemistry and flow cytometry. Unlike gastric and colorectal cancer, only approximately 5% of breast cancer was considered positive for MECA-79 expression, although MECA-79 expression was occasionally observed in membrane and/or cytoplasm of breast cancer cells. MECA-79 expression was not significantly associated with clinicopatholgical parameters or clinical outcomes in breast cancer. Flow cytometric analysis revealed that cell surface MECA-79 expression was found in none of the 5 breast cancer cell lines. The role of ectopic expression of MECA-79 in breast cancer remains unclear, and further studies would be required.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Immunogenic tumor cell death induced by chemotherapy in patients with breast cancer and esophageal squamous cell carcinoma2018

    • Author(s)
      Aoto Keita、Mimura Kousaku、Okayama Hirokazu、Saito Motonobu、Chida Shun、Noda Masaru、Nakajima Takahiro、Saito Katsuharu、Abe Noriko、Ohki Shinji、Ohtake Tohru、Takenoshita Seiichi、Kono Koji
    • Journal Title

      Oncology Reports

      Volume: 39 Pages: 151-159

    • DOI

      10.3892/or.2017.6097

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased expression of CADM1 and CADM4 are associated with advanced stage breast cancer.2018

    • Author(s)
      Saito M, Goto A, Abe N, Saito K, Maeda D, Ohtake T, Murakami Y, Takenoshita S.
    • Journal Title

      Oncol Lett.

      Volume: 15 Pages: 2401-2406

    • DOI

      10.3892/ol.2017.7536

    • NAID

      120007089076

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myeloid-derived suppressor cells are increased and correlated with type 2 immune responses, malnutrition, inflammation, and poor prognosis in patients with breast cancer2017

    • Author(s)
      Gonda Kenji、Shibata Masahiko、Ohtake Tohru、Matsumoto Yoshiko、Tachibana Kazunoshin、Abe Noriko、Ohto Hitoshi、Sakurai Kenichi、Takenoshita Seiichi
    • Journal Title

      Oncology Letters

      Volume: 14 Issue: 2 Pages: 1766-1774

    • DOI

      10.3892/ol.2017.6305

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological Significance of Lymphangiogenesis of Detected by Immunohistochemistry Using D2-40 Monoclonal Antibody in Breast Cancer.2016

    • Author(s)
      Noriko Abe、Tohru Ohtake, Katsuharu Saito, Kensuke Kumamoto, Takashi Sugino,and Siichi Takenoshita
    • Journal Title

      Fukushima J Med Sci

      Volume: 62 Pages: 57-63

    • NAID

      130005156337

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Clinical Relevance of Annexin A1 in Triple-negative Breast Cancer Patients.2017

    • Author(s)
      M. Okano, H.Okayama, T. Ohtake,T. Kawaguchi, L. Yan, Q. Qi, S. Liu, K. Takabe.
    • Organizer
      12th Annual Academic Surgical Congress
    • Place of Presentation
      Las Vegas, Nevada
    • Year and Date
      2017-02-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] トリプルネガティブ乳癌におけるAnnexin A1の発現と臨床病理学的因子との関連および予後の検討2017

    • Author(s)
      立花和之進、岡野舞子、岡山洋和、阿部貞彦、村上祐子、野田勝、阿部宣子、吉田清香、大竹徹
    • Organizer
      第25回日本乳癌学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 乳癌における化学療法が惹起するImmunogenic tumor cell deathの検討2016

    • Author(s)
      青砥慶太、河野浩二、 千田 峻, 野田 勝, 中島 隆宏, 岡山 洋和, 阿部 宣子, 立花 和之進, 岡野 舞子, 大木 進司, 大竹 徹, 竹之下 誠一
    • Organizer
      第24回日本乳癌学会
    • Place of Presentation
      東京ビッグサイト
    • Year and Date
      2016-06-16
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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