| Project/Area Number |
15K10065
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Iwate Medical University |
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Principal Investigator |
Sasaki Akira 岩手医科大学, 医学部, 教授 (40275540)
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| Co-Investigator(Kenkyū-buntansha) |
石垣 泰 岩手医科大学, 医学部, 教授 (50375002)
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| Research Collaborator |
BABA Shigeaki
UMEMURA Akira
NIKAI Haruka
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肥満症 / 非アルコール性脂肪性肝疾患 / 非アルコール性脂肪性肝炎 / インスリン抵抗性 / 肥満外科手術 / 腸内細菌 / ヘパトカイン / 糖尿病 |
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| Outline of Final Research Achievements |
The aim of the present study was to evaluate the effect of laparoscopic sleeve gastrectomy (LSG) on nonalcoholic steatohepatitis (NASH).Seventy-four patients with severe obesity underwent LSG and concomitant intra-operative liver biopsies from 2008 to 2017. Fifty-one patients fulfilled criteria for NASH and 22 patients underwent repeat percutaneous liver biopsy at 1 year after LSG. Mean excess body weight loss at time of repeat biopsy was 57.0%. Mean NAFLD activity score was decreased from 4.7 to 0.2. At the second biopsy, steatosis resolved in 62%, lobular inflammation resolved in 39%, ballooning resolved in 69%, and fibrosis resolved in 39%. Significant differences were observed in the following variables pre- and post-LSG: HOMA-IR (6.3 vs 1.7), liver volume (2,265 vs 1,598 mL), and visceral adipose tissue (271 vs 148 cm2). Metabolic surgery-induced weight loss should be considered as a treatment of choice for NASH patients with severe obesity.
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