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Isolation and functional analysis of blood circulating breast cancer cells by improved telome scan

Research Project

Project/Area Number 15K10069
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionJuntendo University

Principal Investigator

Shimizu Hideo  順天堂大学, 医学部, 准教授 (50424247)

Co-Investigator(Kenkyū-buntansha) 堀本 義哉  順天堂大学, 医学部, 准教授 (40424246)
十合 晋作  順天堂大学, 医学部, 准教授 (80365634)
小見山 博光  順天堂大学, 医学部, 非常勤講師 (30348982)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords血中循環癌細胞 / 乳癌 / 上皮間葉移行
Outline of Final Research Achievements

The development of CTCs as a predictive marker for treatment effects on breast cancer remains an enormous task. We investigated CTCs, including epithelial mesenchymal transition status, from metastatic breast cancer patients who had received eribulin-based treatment. Twenty-two patients were enrolled and peripheral blood samples were collected before eribulin treatment. CTCs were then examined using a Microfluidic Chip device. CTCs positive for vimentin and pan-cytokeratin were defined as mesenchymal and epithelial CTCs, respectively. Numbers of total CTCs were significantly increased in patients with progressive disease during treatment. Patients with more total and mesenchymal CTCs at baseline had significantly shorter progression-free survival.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2017 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] 乳癌における上皮間葉転換 -治療標的としての臨床応用の可能性-2015

    • Author(s)
      猪狩史江、堀本義哉、吉田悠子、徳田恵美、清水秀穂、田辺真彦、齊藤光江
    • Journal Title

      乳癌の臨床

      Volume: 30 Pages: 229-236

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Circulating tumour cell analysis to predict efficacy of Eribulin for metastatic breast cancer patients2017

    • Author(s)
      Yoshiya Horimoto
    • Organizer
      The International Consensus Conference for Advanced Breast Cancer
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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