| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Positive cells in b-Galactosidase and PML were up-regulated and p21 genes and G1 phase cells were amplified by induction of HOXB9. On the other hand, knocking down of p21 and HOXB9 also attenuated cellular senescence. The results showed that HOXB9 induces cellular senescence via p21 pathway.
In addition, in the surgically resected specimens, HOXB9 and p21 were positively correlated, suggesting that HOXB9 and p21 are related.
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