Functional analysis of TREX2 complex in the development and malignant progression of sporadic breast cancers
Project/Area Number |
15K10083
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General surgery
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Research Institution | Niigata University (2016-2017) Aichi Cancer Center Research Institute (2015) |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 乳癌 / 転写共役型DNA傷害 / 乳癌発症機構 / 転写共役型DNA傷害 |
Outline of Final Research Achievements |
We found that the deficiency of GANP, a member of TREX2 complex, resulted in the spontaneous development of mammary gland tumors in mice. To examine if GANP insufficiency is associated with human breast cancer development, we identified several SNPs of ganp and demonstrated one of the SNPs at the ganp locus was significantly associated with reduced breast cancer risk and longer disease-free survival in breast cancer patients. These results suggest that GANP is critical for the occurrence and progression of sporadic breast cancer. In addition, spliced variants in ganp mRNA lacking HAT enzymatic activity was observed in human breast cancer cases, suggesting that the development of sporadic breast cancers is involved in HAT activity of GANP.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] GANP protein encoded on human chromosome 21/mouse chromosome 10 is associated with resistance to mammary tumor development.2016
Author(s)
Kuwahara K, Yamamoto-Ibusuki M, Zhang Z, Phimsen S, Gondo N, Yamashita H, Takeo T, Nakagata N, Yamashita D, Fukushima Y, Yamamoto Y, Iwata H, Saya H, Kondo E, Matsuo K, Takeya M, Iwase H, Sakaguchi N.
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Journal Title
Cancer Sci
Volume: in press
Issue: 4
Pages: 469-477
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Immunodominant SARS coronavirus epitopes in humans elicited both enhancing and neutralizing effects on infection in non-human primates.2016
Author(s)
Wang Q, Zhang L, Kuwahara K, Li L, Liu Z, Li T, Zhu H, Liu J, Xu Y, Xie J, Morioka H, Sakaguchi N, Qin C, Liu G.
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Journal Title
ACS Infectious Diseases
Volume: in press
Issue: 5
Pages: 361-376
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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