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Establishment of the novel bio-marker for early detection and monitoring of gastric cancer with peritoneal dissemination

Research Project

Project/Area Number 15K10086
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionJichi Medical University (2016-2017)
The University of Tokyo (2015)

Principal Investigator

Yamaguchi Hironori  自治医科大学, 医学部, 教授 (20376445)

Co-Investigator(Kenkyū-buntansha) 石原 聡一郎  東京大学, 医学部附属病院, 助教 (00376443)
北山 丈二  自治医科大学, 医学部, 教授 (20251308)
須並 英二  東京大学, 医学部附属病院, 登録研究員 (70345205)
渡邉 聡明  東京大学, 医学部附属病院, 助教授 (80210920)
石神 浩徳  東京大学, 医学部附属病院, 特任講師 (80372382)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords胃癌 / 腹膜播種 / 腹腔内化学療法 / バイオマーカー / 胃癌腹膜播種 / 遺伝子診断
Outline of Final Research Achievements

We quantitatively measured CEA mRNA in the 1268 samples of peritoneal lavage from 68 gastric cancer patients with peritoneal metastasis who received intraperitoneal chemotherapy. The MST of the 20 patients whose CEA mRNA index were below 100 in the preoperative samples was significantly higher compared with the 19 patients whose CEA mRNA index was over 100 (P<0.001). Multivariate analysis revealed that "CEA mRNA index over 100 in preoperative peritoneal lavage samples" was independent risk factor for over all survival in the patients who received gastrectomy after intraperitoneal chemotherapy. The value of CEA mRNA in peritoneal lavage samples is expected as a novel bio-marker for the prediction of the patient's prognosis who received intraperitoneal chemotherapy.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (21 results)

All 2018 2017 2016 2015

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) (of which Int'l Joint Research: 4 results,  Invited: 6 results)

  • [Journal Article] Peritoneal Lavage CEA mRNA Levels Predict Conversion Gastrectomy Outcomes after Induction Chemotherapy with Intraperitoneal Paclitaxel in Gastric Cancer Patients with Peritoneal Metastasis2017

    • Author(s)
      Yamaguchi Hironori、Satoh Yumiko、Ishigami Hironori、Kurihara Makiko、Yatomi Yutaka、Kitayama Joji
    • Journal Title

      Annals of Surgical Oncology

      Volume: 24 Issue: 11 Pages: 3345-3352

    • DOI

      10.1245/s10434-017-5997-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A patient with gastric cancer with peritoneal carcinomatosis treated with intraperitoneal chemotherapy who survived more than 5 years receiving repeated laparoscopic examinations: a case report.2016

    • Author(s)
      YamaguchiH., KitayamaJ., IshigamiH., EmotoS., NishikawaT., TanakaJ., TanakaT., KiyomatsuT., KawaiK., HataK., NozawaH., KazamaS., IshiharaS., SunamiE., WatanabeT.
    • Journal Title

      J Med Case Rep

      Volume: 10 Issue: 1 Pages: 14-14

    • DOI

      10.1186/s13256-016-0799-5

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 胃癌腹膜播種に対する腹腔内化学療法2016

    • Author(s)
      山口博紀, 石神浩徳, 北山丈二.
    • Journal Title

      癌と化学療法

      Volume: 43 Pages: 2481-2485

    • Related Report
      2016 Research-status Report
  • [Journal Article] TRC法を用いた腹腔内洗浄液CEA mRNA定量検査の治療効果判定における有用性2015

    • Author(s)
      佐藤 優実子, 山口 博紀, 高井 大哉, 北山 丈二, 大久保 滋夫, 矢冨 裕
    • Journal Title

      日本臨床検査自動化学会会誌

      Volume: 40 Pages: 603-609

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 転移性腹膜腫瘍の治療 腹膜播種陽性胃癌に対する腹腔内化学療法2015

    • Author(s)
      石神 浩徳, 北山 丈二, 山口 博紀, 渡邉 聡明
    • Journal Title

      外科

      Volume: 77 Pages: 1148-1152

    • Related Report
      2015 Research-status Report
  • [Journal Article] 胃癌の治療 胃癌に対する腹腔内化学療法2015

    • Author(s)
      石神 浩徳, 北山 丈二, 山口 博紀, 渡邉 聡明
    • Journal Title

      臨床消化器内科

      Volume: 30 Pages: 899-902

    • Related Report
      2015 Research-status Report
  • [Journal Article] Breakthrough therapy for peritoneal carcinomatosis of gastric cancer: Intraperitoneal chemotherapy with taxanes.2015

    • Author(s)
      Yamaguchi H, Kitayama J, Ishigami H, Kazama S, Nozawa H, Kawai K, Hata K, Kiyomatsu T, Tanaka T, Tanaka J, Nishikawa T, Otani K, Yasuda K, Ishihara S, Sunami E, Watanabe T.
    • Journal Title

      World J Gastrointest Oncol.

      Volume: 7 Issue: 11 Pages: 285-91

    • DOI

      10.4251/wjgo.v7.i11.285

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Flow Cytometric Quantification of Intraperitoneal Free Tumor Cells is a Useful Biomarker in Gastric Cancer Patients with Peritoneal Metastasis.2015

    • Author(s)
      Kitayama J, Emoto S, Yamaguchi H, Ishigami H, Onoyama H, Yamashita H, Seto Y, Matsuzaki K, Watanabe T.
    • Journal Title

      Ann Surg Oncol.

      Volume: 22(7) Issue: 7 Pages: 2336-42

    • DOI

      10.1245/s10434-014-4238-9

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 胃癌腹膜播種に対する腹腔内化学療法における腹腔洗浄液中 CEA mRNA 定量―手術適応決定のバイオマーカーとしての意義ー2018

    • Author(s)
      山口博紀、石神浩徳、金丸理人 大澤英之 松本志郎 倉科憲太郎 春田英律 細谷好則 北山丈二 佐田尚宏
    • Organizer
      第118回日本外科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Intraperitoneal chemotherapy with paclitaxel for peritoneal metastasis of gastric cancer2018

    • Author(s)
      Hironori Yamaguchi
    • Organizer
      2018 温州胃癌国際フォーラム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Stage IV胃癌への新たな治療戦略 腹膜播種陽性胃癌に対する腹腔内化学療法と手術を組み合わせた治療戦略2017

    • Author(s)
      山口博紀 石神浩徳 北山丈二
    • Organizer
      第25回 日本消化器関連学会週間
    • Related Report
      2017 Annual Research Report
  • [Presentation] 消化器癌の診断・治療を含めた新規分子腫瘍マーカーの意義と展望 胃癌腹膜播種治療における腹腔内液中バイオマーカーの意義2017

    • Author(s)
      北山 丈二, 山口 博紀, 石神 浩則, 大澤 英之, 細谷 好則, 山下 裕玄, 瀬戸 泰之, 佐田 尚宏
    • Organizer
      第72回 日本消化器外科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Intraperitoneal chemotherapy with paclitaxel for peritoneal metastasis of gastric cancer2017

    • Author(s)
      Hironori Yamaguchi
    • Organizer
      2017 中山腫瘍フォーラム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Intraperitoneal Chemotherapy with Paclitaxel: Conversion Surgery for Gastric Cancer with Peritoneal Metastasis2016

    • Author(s)
      Yamaguchi H
    • Organizer
      International Gastric Cancer Forum
    • Place of Presentation
      The Azure Qiantang Hotel, Hanzou, China
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Intraperitoneal chemotherapy with Paclitaxel for peritoneal metrastasis of gastric cancer :from basic research to clinical practice2016

    • Author(s)
      Yamaguchi H
    • Organizer
      The Shanghai Clinical Seminar on Gastrointestinal Oncology
    • Place of Presentation
      Renaissance Yangtze Hotel, Shanghai, China
    • Year and Date
      2016-08-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Theory and Practice of Intraperitoneal Chemotherapy2016

    • Author(s)
      Yamaguchi H
    • Organizer
      China-Japan Exchange Summit on Gastric Cancer Tretment
    • Place of Presentation
      Shanghai Jaotong University, Shanghai, China
    • Year and Date
      2016-08-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 胃癌腹膜播種の新規バイオマーカーとしての腹腔洗浄液中CEA mRNA定量値の有用性2016

    • Author(s)
      山口博紀、石神浩徳、北山丈二、渡邉聡明
    • Organizer
      第71回日本消化器外科学会総会
    • Place of Presentation
      あわぎんホール(徳島)
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 腹膜転移を有する胃癌に対する腹腔内化学療法奏効後の胃切除2015

    • Author(s)
      山口博紀,石神浩徳,北山丈二,渡邉聡明
    • Organizer
      第 77 回 日本臨床外科学会総会
    • Place of Presentation
      浜松
    • Year and Date
      2015-11-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 胃癌腹膜播種症例の治療効果予測因子としての腹腔洗浄液中CEA mRNA定量2015

    • Author(s)
      山口博紀,石神浩徳,北山丈二,渡邉聡明
    • Organizer
      第53回日本癌治療学会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-10-09
    • Related Report
      2015 Research-status Report
  • [Presentation] Quantification of CEAmRNA in peritoneal fluids in patients with peritoneal metastasis of gastric cancer2015

    • Author(s)
      北山 丈二, 石神 浩徳, 山口 博紀
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 癌性腹水をともなう胃癌腹膜播種に対する集学的治療 腹水濾過濃縮再静注法 (CART) と 腹腔内化学療法を併用した積極的治療戦略2015

    • Author(s)
      山口博紀,石神浩徳,北山丈二,渡邉聡明
    • Organizer
      第115回 日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-18
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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