Identification of molecular targets to predict postoperative outcomes in patients with neuroendocrine cell carcinoma of the esophagus
Project/Area Number |
15K10089
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
|
Research Institution | University of Toyama |
Principal Investigator |
Kojima Hirohumi 富山大学, 大学院医学薬学研究部(医学), 助教 (60750114)
|
Co-Investigator(Kenkyū-buntansha) |
奥村 知之 富山大学, 附属病院, 講師 (10533523)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | NEC / esophagus / Esophageal cancer / miRNA / 神経内分泌癌 / 食道癌 / マイクロRNA / マイクロアレイ / 治療効果予測 / 食道原発小細胞癌 |
Outline of Final Research Achievements |
Background: Neuroendocrine cell carcinoma of the esophagus (ENEC) is a rare but very aggressive disease with poor prognosis. The aim of this study was to identify a molecular signature to predict postoperative outcomes in patients with ENEC. Methods: Expression of microRNA was detected in surgically-removed ENEC tumors using microarrays. A SCCE cell line (TYUC-1) was established to investigate the biological role of differentially expressed microRNAs. Results: Hierarchical clustering of microRNA expression revealed two discrete clusters that were identical to the cases with rapid tumor relapse and the cases with long-term survival, respectively. Migration of TYUC-1 was significantly inhibited by downregulation of miR-625. Conclusion: The expression profiles of microRNAs in tumors may represent a novel predictor for postoperative outcomes in patients with ENEC.
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Report
(4 results)
Research Products
(16 results)