Establishment of epigenome panel for identification of lymph node metastasis in gastric cancer
Project/Area Number |
15K10094
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Mie University |
Principal Investigator |
Yasuda Hiromi 三重大学, 医学部附属病院, 助教 (60586767)
|
Co-Investigator(Kenkyū-buntansha) |
問山 裕二 三重大学, 医学部附属病院, 講師 (00422824)
毛利 靖彦 三重大学, 医学系研究科, 客員准教授 (70345974)
楠 正人 三重大学, 医学系研究科, 教授 (50192026)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 胃癌 / リンパ節転移 / 遠隔転移 / microRNA / DNAメチル化 / メチル化 |
Outline of Final Research Achievements |
The aim of this study was to identify clinically relevant epigenetic markers for presence of lymph node metastasis in gastric cancer. Array-based comprehensive analysis demosntrated that miR-4286 expression was significantly increased with disease development and lymph node metastasis in gastric cancer. Although we could not identify approproate candidates of methylated DNA, gene expression analysis demonstrated that increased ANGPTL2 expression was depply involved in lymph node metastasis and poor prognosis in gastric cancer patients.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Clinical Burden of C-Reactive Protein/Albumin Ratio Before Curative Surgery for Patients with Gastric Cancer.2016
Author(s)
Toiyama Y, Shimura T, Yasuda H, Fujikawa H, Okita Y, Kobayashi M, Ohi M, Yoshiyama S, Hiro J, Araki T, Inoue Y, Mohri Y, Kusunoki M.
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Journal Title
Anticancer Res.
Volume: 36
Pages: 6491-6498
Related Report
Peer Reviewed
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[Journal Article] Circulating microRNA-203 predicts metastases, early recurrence, and poor prognosis in human gastric cancer.2015
Author(s)
Imaoka H, Toiyama Y, Okigami M, Yasuda H, Saigusa S, Ohi M, Tanaka K, Inoue Y, Mohri Y, Kusunoki M
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Journal Title
Gastric cancer
Volume: 2 Aug
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Circulating microRNA-203 Predicts Metastases, Early Recurrence, and Poor Prognosis in Human Gastric Cancer2015
Author(s)
Yuji Toiyama, Hiroki Imaoka, Masato Okigami, Hiromi Yasuda, Susumu Saigusa, Masaki Ohi, Minako Kobayashi, Toshimitsu Araki, Koji Tanaka, Yasuhiro Inoue, Yasuhiko Mohri, Masato Kusunoki
Organizer
DDW
Place of Presentation
USA(ワシントンDC)
Year and Date
2015-05-17
Related Report
Int'l Joint Research