Establishment of postoperative adjuvant immunotherapy using peptide pool of tumor antigens in advanced esophageal cancer
| Project/Area Number |
15K10100
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kobe University |
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Principal Investigator |
Nakamura Tetsu 神戸大学, 医学部附属病院, 講師 (10403247)
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| Co-Investigator(Kenkyū-buntansha) |
神垣 隆 神戸大学, 医学部附属病院, 講師 (20372641)
掛地 吉弘 神戸大学, 医学研究科, 教授 (80284488)
山下 公大 神戸大学, 医学部附属病院, 助教 (80535427)
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| Co-Investigator(Renkei-kenkyūsha) |
AOI Takashi 神戸大学, 医学研究科, 特命教授 (00546997)
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| Research Collaborator |
TANAKA Tomoko 神戸大学, 医学部附属病院, 医員
NISHI Masayasu 神戸大学, 医学部附属病院, 医員
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 食道癌 / 補助療法 / T細胞 / ペプチドプール / 養子免疫 |
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| Outline of Final Research Achievements |
In B16-OVA and EG-7 tumor-established mice, in which ovalbumin (OVA) was introduced into B16 melanoma cell line and EL4 T cell lymphoma, activation of antigen-specific T cells was confirmed. Since the number of antigen-specific T cells that can be harvested in the tumor was very small and it was difficult to detect, induction of antigen-specific T cells in the tumor was performed to improve the collection efficiency of intratumoral T cells. We will sequence these tumor reactive T cells and examine data consistency. After that, iPS cellularization will be carried out. We will establish this technology as soon as possible and try to apply human applications.
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Report
(4 results)
Research Products
(10 results)
