| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The Gastrointestinal toxicity in esophageal cancer patients of chemotherapy is among the most important factors limiting its use. Diamine oxidase(DAO) is main enzyme for metabolizing ingested histamine. Recently, an association between polymorphisms of DAO and histamine intolerance. The intestinal mucosal atrophy caused by chemotherapy suppresses histamine metabolism by DAO gane polymorphism , possibly causing nausea and vomiting. The DAO polymorphism was significantly associated with GI toxicities, particularly with anorexia and vomiting during chemotherapy in patients of esophageal cancer. The DAO polymorphism could be used as a predictor of chemotherapy-induced nausea and vomiting.
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