• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the metastasis mechanism of cancer by the fibrinogen and application to new cancer treatment

Research Project

Project/Area Number 15K10113
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionNara Medical University

Principal Investigator

Wakatsuki Kohei  奈良県立医科大学, 医学部, 学内講師 (10405384)

Research Collaborator MATSUMOTO Sohei  
ITO Masahiro  
MIGITA Kazuhiro  
NAKADE Hiroshi  
KUNISHIGE Tomohiro  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsフィブリノーゲン / 上部消化管がん / 予後因子 / フィブリノゲン / 癌 / 浸潤 / 転移
Outline of Final Research Achievements

For upper part gastrointestinal tract cancer (esophageal cancer, stomach cancer), we investigated the association between a plasma fibrinogen level and each clinicopathological factors and prognosis. As for the results, the plasma fibrinogen level (pFib) reflected a progress degree in stomach cancer and esophageal cancer. There was correlation between lymph node metastases and a venous invasion. There was association between pFib and lymphatic recurrence for esophageal cancer. The patients with high pFib significantly had a poorer prognosis than those with low pFib. pFib was an independent prognostic factor of stomach cancer and esophageal cancer. In upper part gastrointestinal tract cancer, we suggested that pFib reflected a cancer progression and was useful for predicting prognosis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Preoperative Plasma Fibrinogen is Associated with Lymph Node Metastasis and Predicts Prognosis in Resectable Esophageal Cancer2017

    • Author(s)
      Kohei Wakatsuki
    • Journal Title

      World Journal of Surgery

      Volume: - Issue: 8 Pages: 2068-2077

    • DOI

      10.1007/s00268-017-3991-x

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 上部消化管がんにおける血漿フィブリノゲンの臨床病理学的意義2018

    • Author(s)
      若月 幸平
    • Organizer
      日本外科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Clinicopathological impacts of plasma fibrinogen for the patients with gastric cancer2017

    • Author(s)
      若月 幸平
    • Organizer
      第89回 胃癌学会
    • Place of Presentation
      広島
    • Related Report
      2016 Research-status Report
  • [Presentation] 胃癌患者における血漿フィブリノゲン値測定の臨床病理学的意義2016

    • Author(s)
      若月幸平
    • Organizer
      第71回日本消化器外科学会
    • Place of Presentation
      徳島
    • Year and Date
      2016-07-14
    • Related Report
      2015 Research-status Report
  • [Presentation] 胃癌患者における血漿フィブリノゲン値測定の臨床病理学的意義2016

    • Author(s)
      若月 幸平
    • Organizer
      第71回日本消化器外科学会総会
    • Place of Presentation
      徳島
    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi