Epigenetic alterations related to efficacy of neoadjuvant therapy before esophagectomy
| Project/Area Number |
15K10124
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | National Center for Global Health and Medicine |
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Principal Investigator |
Yamada Kazuhiko 国立研究開発法人国立国際医療研究センター, その他部局等, 医長 (70401081)
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| Co-Investigator(Kenkyū-buntansha) |
河村 由紀 国立研究開発法人国立国際医療研究センター, その他, 消化器病態生理研究室長 (10392391)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 癌 / 食道扁平上皮癌 / 化学放射線療法 |
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| Outline of Final Research Achievements |
Esophageal squamous cell carcinoma (ESCC) is an aggressive form of cancer. Surgery and combined therapies, such as chemotherapy, radiotherapy, or synchronous chemoradiotherapy, have significantly developed in the past several years. To improve the survival rate of ESCC, identifying new markers to predict efficacy of preoperative chemotherapy and/or irradiation is urgently needed. The aim of this study is to identify differences in gene expression and epigenetic alterations between between responders and non-responders who have received neoadjuvant chemotherapy or chemoradiotherapy before esophagectomy for ESCC. We performed integrative transcriptomics by RNA sequencing and methylome sequencing by methyl-DNA immunoprecipitation (MeDIP) analysis. We found genes whose expression levels were different between responders and non-responders; however, there was no difference in their DNA methylation levels between responders and non-responders.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] DNA Hypermethylation and silencing of PITX1 correlated with advanced stage and poor postoperative prognosis of esophageal squamous cell carcinoma2017
Author(s)
Otsubo T, Yamada K, Hagiwara T, Oshima K, Iida K, Nishikata K, Toyoda T, Igari T, Nohara K, Yamashita S, Hattori M, Dohi T and Kawamura YI.
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Journal Title
Ongotarget
Volume: 8
Issue: 48
Pages: 84434-84448
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Fatty acids in a high-fat diet potentially induce gastric parietal-cell damage and metaplasia in mice2016
Author(s)
Hirata, Y. Sezaki, T. Tamura-Nakano, M. Oyama, C. Hagiwara, T. Ishikawa, T. Fukuda, S. Yamada, K. Higuchi, K. Dohi, T. Kawamura, Y. I.
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Journal Title
J Gastroenterol
Volume: -
Issue: 8
Pages: 889-903
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Telomere Visualization in Tissue Sections Using Pyrrole-Imidazole Polyamide Probes.2016
Author(s)
Sasaki, A., Ide, S., Kawamoto, Y., Bando, T., Murata, Y., Shimura, M., Yamada, K., Hirata, A., Nokihara, K., Hirata, T., Sugiyama, H., Maeshima, K.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 29261-29261
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] DNA hypermethylation of PITX1 correlated with poor prognosis of esophageal squamous cell carcinoma.2017
Author(s)
Yamada K, Otsubo T, Hagiwara T, Oshima K, Iida K, Nishikata K, Toyoda T, Igari T, Nohara K, Soma D, Kataoka A, Yamashita S, Hattori M, Dohi T, Kawamura YI.
Organizer
The 28th Annual Meeting of the European Society for Diseases of the Esophagus (ESDE)
Related Report
Int'l Joint Research
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[Presentation] Expression of the desmosome-related periplakin is associated with advanced stage of esophageal squamous cell carcinoma.2017
Author(s)
Yamada K, Kawamura YI, Hagiwara T, Inazuka F, Sezaki T, Dohi T, Nohara K, Soma D, Yamashita S, Edamoto Y, Yano H, Hashimoto M, Kokudo N.
Organizer
The 15th World Congress of the OESO
Related Report
Int'l Joint Research
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[Presentation] PRS27 is downregulated in esophageal squamous cell carcinoma in association with aberrant DNA hypermethylation.2016
Author(s)
Sugimoto T, Hagiwara T, Yamada K, Oyama C, Tamura-Nakano M, Nohara K, Soma D, Yamashita S, Shiba D, Igari T, Yokoi C, Dohi T, Kawamura Y.
Organizer
ヨーロッパ食道学会
Place of Presentation
ミュンヘン
Year and Date
2016-12-01
Related Report
Int'l Joint Research
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[Presentation] 食道癌における網羅的メチル化解析より見出されたデスモソーム関連分子periplakinと臨床病理学的検討.2016
Author(s)
山田 和彦, 河村 由紀, 山田 純, 野原 京子, 山下 智, 萩原 輝記, 大坪 武史, 中野 美和[田村], 瀬崎 拓人, 土肥 多恵子, 枝元 良広, 徳原 真, 橋本 政典, 矢野 秀朗.
Organizer
日本外科学会総会
Place of Presentation
大阪
Year and Date
2016-04-14
Related Report
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[Presentation] 消化器外科領域における医療安全の状況2015
Author(s)
山田 和彦, 山田 純, 野原 京子, 山下 智, 矢野 秀朗, 橋本 政典, 六ツ見 しのぶ, 廣井 透雄, 蓑和田 滋, 岡本 竜哉
Organizer
国立病院総合医学会総会
Place of Presentation
ロイトン札幌 札幌
Year and Date
2015-10-01
Related Report
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