| Project/Area Number |
15K10128
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
内藤 剛 東北大学, 医学系研究科, 准教授 (50291258)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | DPYD / MTHFR / OPRT / TYMS / 5-FU / splicing / 遺伝子多型 / DPD / 有害事象 / 胃癌 / 大腸癌 / ABC transporter |
|---|
| Outline of Final Research Achievements |
The aim of this study was to investigate the association between 5-fluorouracil (5-FU)-related adverse events (AEs) in Japanese patients with gastrointestinal cancer treated with 5-FU and the patient genotypes DPYD, MTHFR, OPRT, and TYMS. Methods: Sequence analyses of 33 gene polymorphisms in four genes were performed using genomic DNA extracted from peripheral blood mononuclear cells of 88 patients with gastric (n = 30) or colorectal (n = 58) cancer. The associations between the incidence of AEs and each genotype were statistically analyzed. Results: The patients carrying any one of three DPYD SNPs (c.496A>G, c.1905+1G>A, and c.2303C>A) showed statistically significant associations with the incidence of AEs, especially fatigue, and the MTHFR SNP c.1298A>C was significantly associated with the incidence of neutropenia. Conclusion: These findings suggest that the genetic polymorphisms of DPYD and MTHFR may be predictive factors for the occurrence of severe 5-FU-related AEs.
|
