ES cell-specific transcription factor ZFP57 promotes liver metastasis of colorectal cancer
| Project/Area Number |
15K10131
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ZFP57 / 大腸癌 / 肝転移 / Zfp57 |
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| Outline of Final Research Achievements |
In liver metastatic experiments using human colorectal cancer cell lines, liver polymetastasis occurred with high frequency in the case of ZFP57-overexpressing cells, while control cells produced only oligometastasis. When we examined the relationship between the clinicopathological feature of colorectal cancer and ZFP57 overexpression using clinical specimens, liver metastasis-positive cases were more frequently associated with ZFP57 overexpression than negative cases in primary lesions of colorectal cancer. In addition, the expression level of ZFP57 showed significant correlations with that of NANOG, a metastasis-related gene. We also found that ZFP57 overexpression results in reduced disease-free survival rate of patients in colorectal cancer.
This study demonstrated that ZFP57 plays an important role in liver metastasis of colorectal cancer. ZFP57 would be a novel target molecule of treatment for liver metastasis of colorectal cancer.
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Report
(4 results)
Research Products
(3 results)
