| Project/Area Number |
15K10132
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
今野 弘之 浜松医科大学, 医学部, 学長 (00138033)
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| Research Collaborator |
Murakami Tomohiro 浜松医科大学, 大学院生
Ishimatsu Hisato 浜松医科大学, 大学院生
Baba Satoshi 浜松医科大学, 医学部附属病院, 病院教授
Kitagawa Masatoshi 浜松医科大学, 医学部, 教授
Kitagawa Kyoko 浜松医科大学, 医学部, 助教
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | マイクロRNA / 肝転移 / 腫瘍間質 / 微小環境 / tenascin C / 大腸癌 / 腫瘍周囲間質 / 消化管間質腫瘍 / 予後予測マーカー / 癌 / マイクロアレイ / 転移 |
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| Outline of Final Research Achievements |
To identify mechanisms of liver metastasis, microRNA expression was analyzed in colorectal cancer (CRC) stroma and gastrointestinal stromal tumors (GISTs). In CRC,
suppression of miR-198 in tumor stroma appears to form a metastasis-permissive environment that can elevate tenascin C to promote liver metastasis. Tenascin C expression in CRC stroma was identified as a novel molecular marker of CRC to predict postoperative liver metastasis. In GIST, overexpression of miR-122 and concomitant suppression of CAT1, and suppression of miR-133b and concomitant overexpression of fascin-1 protein appear to play important roles in the development of liver metastasis.
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