• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Postoperative anti-TNF-alpha monoclonal antibody maintenance therapy for Japanese patients with Crohn's disease

Research Project

Project/Area Number 15K10133
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionNagoya University

Principal Investigator

NAKAYAMA Goro  名古屋大学, 医学部附属病院, 講師 (90422782)

Co-Investigator(Kenkyū-buntansha) 藤井 努  富山大学, 大学院医学薬学研究部(医学), 教授 (60566967)
小寺 泰弘  名古屋大学, 医学系研究科, 教授 (10345879)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsクローン病 / 抗TNF-α抗体 / インフリキシマブ / アダリマブ / インフリキシマズ / マダリマブ / アダリムマブ
Outline of Final Research Achievements

The prevention of postoperative recurrence is a critical issue in surgery for Crohn’s disease (CD). The aim of this study was to investigate the efficacy and safety of planned postoperative anti-TNF-α therapy after surgery in Japanese patients with CD. Twenty-six patients with CD undergoing surgical resection were enrolled. All patients received postoperative anti-TNF-α, adalimumab (ADA), therapy within 2 weeks after surgery. The primary endpoint of this study was the incidence of endoscopic recurrence. Endoscopic recurrence was observed in 31% of patients 1 year after surgery. Univariate analyses show that preoperative ADA therapy was significantly associated with endoscopic recurrence. 17% of patients experienced clinical recurrence 1 year after surgery. Secondary surgery for recurrence was not required. Planned postoperative ADA therapy reduced the incidence of endoscopic and clinical recurrence after bowel resection of Japanese patients with CD.

Academic Significance and Societal Importance of the Research Achievements

クローン病の術後寛解維持療法としてアダリムマブの有効性を検討した国内初めての前方視的臨床研究であり,術後再発を抑制するための新たな治療戦略を示唆する成果であると考える.

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2019 2018 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Postoperative adalimumab maintenance therapy for Japanese patients with Crohn's disease: a single-center, single-arm phase II trial (CCOG-1107 study)2018

    • Author(s)
      Takashi Asada,Goro Nakayama, Chie Tanaka, Daisuke Kobayashi, Kazuhiro Ezaka, Norifumi Hattori, Mitsuro Kanda, Suguru Yamada, Masahiko Koike, Yasuhiro Kodera
    • Journal Title

      Surgery Today

      Volume: [Epub ahead of print] Issue: 6 Pages: 609-617

    • DOI

      10.1007/s00595-018-1634-y

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] クローン病に対する術後抗TNF-α抗体(アダリムマブ)維持療法の中長期成績―CCOG-1107試験結果より―2019

    • Author(s)
      中山吾郎,服部憲史,佐藤雄介,上原圭介,相場利貞,山田 豪,小池聖彦,梛野正人,小寺泰弘
    • Organizer
      第119回日本外科学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 潰瘍性大腸炎に対する腹腔鏡下大腸全摘+回腸嚢肛門(管)吻合術における当科の工夫と治療成績2015

    • Author(s)
      中山吾郎,田中千恵,服部憲史,二宮 豪,服部正嗣,小寺泰弘
    • Organizer
      第70回日本大腸肛門病学会学術集会
    • Place of Presentation
      名古屋観光ホテル (愛知県名古屋市)
    • Year and Date
      2015-11-13
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi