| Project/Area Number |
15K10134
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
問山 裕二 三重大学, 医学部附属病院, 講師 (00422824)
井上 靖浩 三重大学, 医学系研究科, 客員准教授 (20324535)
楠 正人 三重大学, 医学系研究科, 教授 (50192026)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 大腸癌 / 腹膜播種 / microRNA / 肝転移 |
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| Outline of Final Research Achievements |
To identify miRNA biomakers for peritoneal metastasis in colorectal cancer and to clarify the funtional mechanism of these miRNAs for development of peritoneal metastasis, we performed array-based comprehesive analysis. From this result, we demonstrated that serum miR-1290 was significantly increased in CRC patients compared to healthy volunteers, and increased serum miR-1290 was significantly correlated with recurrence and poor survival in CRC. Especially, serum miR-1290 was significantly increased in CRC patients harboring peritoneal metastasis, and suggested that serum miR-1290 might be used as a predictive biomarker for peritoneal metastasis in CRC patients.
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