Comprehensive analysis of microRNAs associated with peritoneal dissemination of colorectal cancer and treatment strategy
Project/Area Number |
15K10134
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Mie University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
問山 裕二 三重大学, 医学部附属病院, 講師 (00422824)
井上 靖浩 三重大学, 医学系研究科, 客員准教授 (20324535)
楠 正人 三重大学, 医学系研究科, 教授 (50192026)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
Keywords | 大腸癌 / 腹膜播種 / microRNA / 肝転移 |
Outline of Final Research Achievements |
To identify miRNA biomakers for peritoneal metastasis in colorectal cancer and to clarify the funtional mechanism of these miRNAs for development of peritoneal metastasis, we performed array-based comprehesive analysis. From this result, we demonstrated that serum miR-1290 was significantly increased in CRC patients compared to healthy volunteers, and increased serum miR-1290 was significantly correlated with recurrence and poor survival in CRC. Especially, serum miR-1290 was significantly increased in CRC patients harboring peritoneal metastasis, and suggested that serum miR-1290 might be used as a predictive biomarker for peritoneal metastasis in CRC patients.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Prognostic impact of sarcopenia and its correlation with circulating miR-21 in colorectal cancer patients.2018
Author(s)
Okugawa Y, Yao L, Toiyama Y, Yamamoto A, Shigemori T, Yin C, Omura Y, Ide S, Kitajima T, Shimura T, Fujikawa H, Yasuda H, Hiro J, Yoshiyama S, Kobayashi M, Tanaka K, Inoue Y, Araki T, Miki C, Kusunoki M.
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Journal Title
Oncol Rep.
Volume: 39
Pages: 1555-1564
DOI
Related Report
Peer Reviewed
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[Journal Article] Prognostic Impact of Preoperative Albumin-to-Globulin Ratio in Patients with Colon Cancer Undergoing Surgery with Curative Intent.2017
Author(s)
Fujikawa H, Toiyama Y, Inoue Y, Imaoka H, Shimura T, Okigami M, Yasuda H, Hiro J, Yoshiyama S, Saigusa S, Kobayashi M, Ohi M, Araki T, Mohri Y, Kusunoki M.
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Journal Title
Anticancer Res.
Volume: 37
Pages: 1335-1342
Related Report
Peer Reviewed
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[Journal Article] Proteomics analysis of differential protein expression identifies heat shock protein 47 as a predictive marker for lymph node metastasis in patients with colorectal cancer.2017
Author(s)
Mori K, Toiyama Y, Otake K, Fujikawa H, Saigusa S, Hiro J, Kobayashi M, Ohi M, Tanaka K, Inoue Y, Kobayashi Y, Kobayashi I, Mohri Y, Goel A, Kusunoki M.
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Journal Title
Int J Cancer.
Volume: 140
Issue: 6
Pages: 1425-1435
DOI
Related Report
Peer Reviewed
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[Journal Article] Successful identification of a predictive biomarker for lymph node metastasis in colorectal cancer using a proteomic approach.2017
Author(s)
Mori K, Toiyama Y, Otake K, Ide S, Imaoka H, Okigami M, Okugawa Y, Fujikawa H, Saigusa S, Hiro J, Kobayashi M, Ohi M, Tanaka K, Inoue Y, Kobayashi Y, Mohri Y, Kobayashi I, Goel A, Kusunoki M.
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Journal Title
Oncotarget.
Volume: 8
Issue: 63
Pages: 106935-106947
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] MicroRNA-7 Is Associated with Malignant Potential and Poor Prognosis in Human Colorectal Cancer.2016
Author(s)
Nagano Y, Toiyama Y, Okugawa Y, Imaoka H, Fujikawa H, Yasuda H, Yoshiyama S, Hiro J, Kobayashi M, Ohi M, Araki T, Inoue Y, Mohri Y, Kusunoki M.
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Journal Title
Anticancer Res.
Volume: 36
Pages: 6521-6526
Related Report
Peer Reviewed
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[Journal Article] miRNA-503 Promotes Tumor Progression and Is Associated with Early Recurrence and Poor Prognosis in Human Colorectal Cancer.2016
Author(s)
Noguchi T, Toiyama Y, Kitajima T, Imaoka H, Hiro J, Saigusa S, Tanaka K, Inoue Y, Mohri Y, Toden S, Kusunoki M.
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Journal Title
Related Report
Peer Reviewed / Acknowledgement Compliant
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