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Development of the new treatment strategy targeting microRNA which controls histone de-methylase

Research Project

Project/Area Number 15K10142
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionKumamoto University

Principal Investigator

SAKAMOTO Yasuo  熊本大学, 医学部附属病院, 非常勤診療医師 (00452897)

Co-Investigator(Kenkyū-buntansha) 馬場 祥史  熊本大学, 医学部附属病院, 特任講師 (20599708)
宮本 裕士  熊本大学, 医学部附属病院, 講師 (80551259)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsJMJD3 / microRNA / EZH2 / 大腸癌 / mir186-5p
Outline of Final Research Achievements

We identified microRNA, miR186-5p which suppress the expression of histone de-methylase JMJD3 with enzyme activity opposite to EZH2. We confirmed that the suppression of JMJD3, CDH1, VASH1, and TFAP2E by the over-expression of miR186-5p in colon cancer cell line. We confirmed that cisplatin sensitivity was increased when I controlled expression of histone methylase EZH2 in colon cancer cell line.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] The Prognostic Significance of Histone Lysine Demethylase JMJD3/KDM6B in Colorectal Cancer.2016

    • Author(s)
      Tokunaga R, Sakamoto Y, Nakagawa S, Miyake K, Izumi D, Kosumi K, Taki K, Higashi T, Imamura Y, Ishimoto T, Iwatsuki M, Baba Y, Miyamoto Y, Yoshida N, Oki E, Watanabe M, Baba H.
    • Journal Title

      Ann Surg Oncol

      Volume: 23(2) Issue: 2 Pages: 678-85

    • DOI

      10.1245/s10434-015-4879-3

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Retroileal colorectal anastomosis after extended left colectomy: application for laparoscopic surgery.2016

    • Author(s)
      Sakamoto Y, Tokunaga R, Miyamoto Y, Ohuchi M, Nakamura K, Kosumi K, Harada K, Shigaki H, Kurashige J, Iwatsuki M, Baba Y, Yoshida N, Baba H.
    • Journal Title

      Surg Today.

      Volume: 46(12) Issue: 12 Pages: 1476-1478

    • DOI

      10.1007/s00595-016-1313-9

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 腹腔鏡下前方切除術における縫合不全予防のための工夫2017

    • Author(s)
      坂本快郎、大内繭子、内原智幸、問端 輔、八木泰佑、中村健一、美馬浩介、澤山 浩、木下浩一、岩槻政晃、馬場祥史、吉田直矢、馬場秀夫
    • Organizer
      第86回大腸癌研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 内臓肥満が大腸癌に与える影響: Leptinは女性の大腸癌予後を悪化させる2017

    • Author(s)
      宮本裕士、大内繭子、坂本快郎、徳永竜馬、織田枝里、澤山 浩、岩槻政晃、馬場祥史、吉田直矢、馬場秀夫
    • Organizer
      第72回日本消化器外科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 大腸癌切除症例において術後合併症が予後に与える影響2017

    • Author(s)
      宮本裕士、日吉幸晴、坂本快郎、澤山 浩、岩槻政晃、馬場祥史、吉田直矢、馬場秀夫
    • Organizer
      JDDW 2017
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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