Prevention of radiation enteritis using Juzentaihoto enhanced anti-oxidant action

• Project/Area Number: 15K10145
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Nara Medical University
• Principal Investigator: Koyama Fumikazu 奈良県立医科大学, 医学部, 病院教授 (40316063)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 放射線性腸炎 / 十全大補湯 / 黄耆 / 漢方薬 / ミトコンドリア / 漢方 / 抗酸化作用

Outline of Final Research Achievements

In this study, we examined the preventive and therapeutic effects on the rat radiation enteritis by Juzentaihoto which enhanced anti-oxidant action with increased Ougi (the modified Juzentaihoto). Especially focusing on the mitochondrial functions, we examined whether enhanced Juzentaihoto could prevent irradiation induced apoptosis of rat intestinal cells through preservation of the mitochondrial functions. Our data indicated that the modified Juzentaihoto could enhance the anti-oxidant activity of rat inetestinal mitochondria and could reduce the number of apoptotic cell of rat intestinal cells after irradiation, yet could not prevent the intestinal injury from irradiation.