Monitoring of epithelial-mesenchymal transition related genes underlying cancer metastasis and invasion
| Project/Area Number |
15K10147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 浩一 自治医科大学, 医学部, 准教授 (70332369)
力山 敏樹 自治医科大学, 医学部, 教授 (80343060)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 上皮間葉系移行 / 大腸がん / 転移 / VEGF / Liquid Biopsy / VFGF / VFGFリガンド / 大腸癌 / 転移のメカニズム / 腫瘍内不均一性 |
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| Outline of Final Research Achievements |
Increasing evidence suggests that epithelial-mesenchymal transition (EMT) plays an important role in tumor progression and metastasis formation but there is no evidence in human tumors. It may be the great diversity in cellular organization, known as intratumor heterogeneity. We calculated the expression ratios between the tumor center and invasive front in each tumor. This approach enabled recognition of the activation of the VEGF and Wnt signaling pathways, which were involved in metastasis via promotion of EMT. They were preferentially activated at the invasive front in metastatic tumors. Furthermore, we found 20 % of colorectal patients showed the overexpression of VEGF-A and they were more likely to relapse and metastasize.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Monitoring circulating tumor DNA revealed dynamic changes in KRAS status in patients with metastatic colorectal2018
Author(s)
Yuji Takayama, Koichi Suzuki, Yuta Muto, Kosuke Ichida, Taro Fukui, Nao Kakizawa, Hideki Ishikawa, Fumiaki Watanabe, Fumi Hasegawa, Masaaki Saito, Shingo Tsujinaka, Kazushige Futsuhara, Yasuyuki Miyakura, Hiroshi Noda, Fumio Konishi, Toshiki Rikiyama
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Journal Title
Oncotarget
Volume: 9
Issue: 36
Pages: 24398-24413
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Overexpression of satellite alpha transcripts leads to chromosomal instability via segregation errors at specific chromosomes.2018
Author(s)
Ichida K, Suzuki K, Fukui T, Takayama Y, Kakizawa N, Watanabe F, Ishikawa H, Muto Y, Kato T, Saito M, Futsuhara K, Miyakura Y, Noda H, Ohmori T, Konishi F, Rikiyama T.
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Journal Title
Int J Oncol.
Volume: -
Pages: 1685-1693
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Heterogeneous expression of zinc-finger E-box-binding homeobox 1 plays a pivotal role in metastasis via regulation of miR-200c in epithelial-mesenchymal transition2016
Author(s)
Muto Y, Suzuki K, Kato T, Tsujinaka S, Ichida K, Takayama Y, Fukui T, Kakizawa N, Watanabe F, Saito M, Futsuhara K, Noda H, Miyakura Y, Konishi F and Rikiyama
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Journal Title
Int J Oncol.
Volume: 49(3)
Issue: 3
Pages: 1057-1067
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Appearance of KRAS mutated circulating tumor DNA during various treatments for metastatic colorectal cancer patients2017
Author(s)
Takayama Y, Suzuki K, Ichida K, Fukui T, Kakizawa N, Watanabe F, Hasegawa F, Tsujinaka S, Miyakura Y, Noda H, Rikiyama T
Organizer
Exosomes and Liquid Biopsies ASIA
Related Report
Int'l Joint Research
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