| Project/Area Number |
15K10147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 浩一 自治医科大学, 医学部, 准教授 (70332369)
力山 敏樹 自治医科大学, 医学部, 教授 (80343060)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 上皮間葉系移行 / 大腸がん / 転移 / VEGF / Liquid Biopsy / VFGF / VFGFリガンド / 大腸癌 / 転移のメカニズム / 腫瘍内不均一性 |
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| Outline of Final Research Achievements |
Increasing evidence suggests that epithelial-mesenchymal transition (EMT) plays an important role in tumor progression and metastasis formation but there is no evidence in human tumors. It may be the great diversity in cellular organization, known as intratumor heterogeneity. We calculated the expression ratios between the tumor center and invasive front in each tumor. This approach enabled recognition of the activation of the VEGF and Wnt signaling pathways, which were involved in metastasis via promotion of EMT. They were preferentially activated at the invasive front in metastatic tumors. Furthermore, we found 20 % of colorectal patients showed the overexpression of VEGF-A and they were more likely to relapse and metastasize.
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