| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The purpose of this study was to develop a detection method of circulating tumor cells (CTC) specific to hepatocellular carcinoma and construct a system to accurately predict metastasis of hepatocellular carcinoma, and to establish a control method of CTC based on immune-related gene polymorphism analysis.
We established Glypican-3 (GPC3) positive CTC detection method using the magnetic cell separation system. Among 88 HCC resected cases, 53 cases (60.2%) were CTC positive and CTC positive (p<0.001) was an independent risk factor for portal vein invasion. CTC positive was also an independent risk factor for relapse-free survival (p=0.029). GPC3-CTC reflects portal vein invasion and postoperative recurrence and is a reasonable candidate as a target for postoperative adjuvant therapy.
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