Analysis of tumor-stromal interaction via complement C5a receptor in cancer microenvironment
Project/Area Number |
15K10171
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
|
Research Institution | Kumamoto University |
Principal Investigator |
NAKAHARA Osamu 熊本大学, 医学部附属病院, 非常勤診療医師 (40583042)
|
Co-Investigator(Kenkyū-buntansha) |
岡部 弘尚 熊本大学, 医学部附属病院, 助教 (40573621)
橋本 大輔 熊本大学, 医学部附属病院, その他 (80508507)
新田 英利 熊本大学, 医学部附属病院, 助教 (90555749)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | C5a受容体 / ヒト肝星細胞 / 肝細胞癌 / 補体C5a / 癌間質細胞 / 肝星細胞 / 浸潤 / 転移 |
Outline of Final Research Achievements |
The Aim of this study is to analyze tumor-stromal interaction via C5a-C5aR axis in hepatocellular carcinoma (HCC). At first, we investigated whether human hepatic stellate cells (HSC) were in activated state or not in resected HCC specimen using confocal microscope. The result that αSMA staining, which is marker of activation in HSC, was detected in HSC around HCC lesions, meant that HSC was in activated state around human HCCs. In vitro, western blotting analysis revealed C5aR expression at HSC in a time dependent manner. Moreover, HSC increased αSMA expression by C5a stimulation. Therefore, HSC could be activated by C5a-C5aR axis. In addition, C5a stimulation increased HCC invasion and that was inhibited by C5aR-antagonist. From these results, C5a-C5aR could be a target therapy for HCC treatment.
|
Report
(4 results)
Research Products
(14 results)
-
[Journal Article] Clinical significance of half-lives of tumor markers α-fetoprotein and des-γ-carboxy prothrombin after hepatectomy for hepatocellular carcinoma.2018
Author(s)
Tsukamoto M, Nitta H, Imai K, Higashi T, Nakagawa S, Okabe H, Arima K, Kaida T, Taki K, Hashimoto D, Chikamoto A, Ishiko T, Beppu T, Baba H
-
Journal Title
Hepatol Res.
Volume: 48
Issue: 3
DOI
Related Report
Peer Reviewed
-
[Journal Article] Pre-treatment double- or triple-positive tumor markers are predictive of a poor outcome for patients undergoing radiofrequency ablation for hepatocellular carcinoma.2017
Author(s)
itta H, Nakagawa S, Kaida T, Arima K, Higashi T, Taki K, Okabe H, Hayashi H, Hashimoto D, Chikamoto A, Ishiko T, Beppu T, Baba H.
-
Journal Title
Surg Today
Volume: 47(3)
Issue: 3
Pages: 375-384
DOI
Related Report
Peer Reviewed
-
[Journal Article] Preoperative platelet-to-lymphocyte ratio can predict recurrence beyond the Milan criteria after hepatectomy for patients with hepatocellular carcinoma.2016
Author(s)
Kaida T, Nitta H, Kitano Y, Yamamura K, Arima K, Higashi T, Taki K, Nakagawa S, Okabe H, Hayashi H, Imai K, Hashimoto D, Yamashita YI, Chikamoto A, Ishiko T, Beppu T, Baba H.
-
Journal Title
Hepatol Res
Volume: Epub ahead of print
Issue: 10
Pages: 991-999
DOI
Related Report
Peer Reviewed
-
[Journal Article] C5a receptor (CD88) promotes motility and invasiveness of gastric cancer by activating RhoA.2016
Author(s)
Kaida T, Nitta H, Kitano Y, Yamamura K, Arima K, Izumi D, Higashi T, Kurashige J, Imai K, Hayashi H, Iwatsuki M, Ishimoto T, Hashimoto D, Yamashita Y, Chikamoto A, Imanura T, Ishiko T, Beppu T, Baba H.
-
Journal Title
Oncotarget.
Volume: 20(7)
Issue: 51
Pages: 84798-84809
DOI
Related Report
Peer Reviewed
-
[Journal Article] Degenerative hepatic hemangioma mimicking biliary cystadenocarcinoma.2016
Author(s)
Kaida T, Higashi T, Kitano Y, Yamamura K, Arima K, Taki K, Imai K, Nitta H, Hashimoto D, Chikamoto A, Namimoto T, Nakahara O, Beppu T, Baba H
-
Journal Title
J Gastroenterol Hepatol
Volume: 31(8)
Issue: 8
Pages: 1385-1385
DOI
Related Report
Peer Reviewed
-
[Journal Article] Expression of anaphylatoxin C5a receptor in gastric cancer: Implications with vascular invasion and patient outcome.2016
Author(s)
Nitta, H., Shimose, T., Emi, Y., Imamura, T., Ohnishi, K., Kusumoto, T., Yamamoto. M., Fukuzawa, K., Takahashi, I., Higashi, H., Tsuji, A., Akagi, Y., Oki, E., Maehara, Y., & Baba, H.
-
Journal Title
Med. Oncol.
Volume: 33
Issue: 11
Pages: 118-118
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Chemotherapy-induced Nausea and Vomiting in Patients with Hepatobiliary and Pancreatic Cancer Treated with Chemotherapy2016
Author(s)
Nitta H, Baba H, Sugimori K, Furuse J, Ohkawa S, Yamamoto K, Minami H, Shimokawa M, Wakabayashi GO, Aiba K, Japan CSGo
-
Journal Title
Anticancer Res
Volume: 36(4)
Pages: 1929-35
Related Report
Peer Reviewed
-
-
[Presentation] Prognostic value and prediction of extra-tumoral microvascular invasion among candidates for hepatectomy or liver transplantation for HCC2017
Author(s)
Hidetoshi Nitta, Marc-Antoine Allard, Gabriella Pittau, Oriana Ciacio, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Denis Castaing, Henri Bismuth, Hideo Baba, and Rene Adam
Organizer
EASL2017
Related Report
Int'l Joint Research
-
[Presentation] Predictive model for microvascular invasion of hepatocellular carcinoma among candidates for either hepatectomy or liver transplantation.2017
Author(s)
Hidetoshi Nitta, Marc-Antoine Allard, Mylène Sebagh, Gabriella Pittau, Oriana Ciacio, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Denis Castaing, Henri Bismuth, Catherine Guettier, Didier Samuel, Hideo Baba, and Rene Adam
Organizer
ASCO2017
Related Report
Int'l Joint Research
-
[Presentation] Analysis of risk factors of early recurrence and ideal surgical margin for hepatocellular carcinoma.2017
Author(s)
Hidetoshi Nitta, Marc-Antoine Allard, Mylene Sebagh, Oriana Ciacio, Gabriella Pittau, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Denis Castaing, Henri Bismuth, Hideo Baba, and Rene Adam
Organizer
ESMO GI 2017
Related Report
Int'l Joint Research
-
[Presentation] Establishment of predictive model for microvascular invasion of hepatocellular carcinoma and Clinical usage of the model for decision of surgical strategy.2017
Author(s)
Hidetoshi Nitta, Marc-Antoine Allard, Mylene Sebagh, Gabriella Pittau, Oriana Ciacio1, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Denis Castaing, Henri Bismuth, Catherine Guettier, Didier Samuel, Hideo Baba, and Rene Adam
Organizer
ILTS2017
Related Report
Int'l Joint Research
-
[Presentation] Prognostic value and prediction of extra-tumoral microvascular invasion among patients who candidate for hepatectomy or liver transplantation for hepatocellular carcinoma.2017
Author(s)
Hidetoshi Nitta , Marc-Antoine Allard, Gabriella Pittau, Oriana Ciacio, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Denis Castaing, Henri Bismuth, Hideo Baba, Rene Adam
Organizer
EASL2017
Place of Presentation
Amsterdam, Netherlands
Related Report
Int'l Joint Research
-