| Project/Area Number |
15K10174
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
近江谷 克裕 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究部門長 (20223951)
植村 芳子 関西医科大学, 医学部, 教授 (50148508)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 癌光イメージング法迅速定量病理診断法 / 大腸癌転移性肝癌 / 腹膜播種性転移 / リンパ節転移 / CEA / 大腸癌 / 癌光イメージング法 / 迅速定量病理診断法 / 肝細胞癌 |
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| Outline of Final Research Achievements |
Identification of CEA in cancer cells using an anti-carcinoembryonic antigen (CEA) -far-red bioluminescent probe (FBP) antibody, which is a probe obtained by fusing a cancer antibody marker and a photoprotein, was carried out by comparing the CEA. It is possible to apply not only tumor lesion but also metastatic lesion. In the liver metastasis, lymph node metastasis, peritoneal disseminated metastasis, etc. of colorectal cancer, cancer optical imaging using anti-CEA-FBP antibody has not been investigated so far. In this study, we examined the optimization condition of anti-CEA-FBP antibody within the research period in order to investigate the presence or absence of cancer optical imaging using the tissue section of the surgical resected metastatic lesion.
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