Comprehensive influence on tumor immune system by interaction between pancreatic cancer and molecules of tumor microenvironment.

• Project/Area Number: 15K10190
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Nagasaki University
• Principal Investigator: NAGAI Kazuhiro 長崎大学, 病院(医学系), 講師 (30304942)
• Co-Investigator(Kenkyū-buntansha): 岡本 正人 北里大学, 薬学部, 特任教授 (10243718) ; 下平 滋隆 信州大学, 医学部附属病院, 特任教授 (80345751) ; 黒木 保 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (90404219)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 腫瘍免疫 / 膵臓癌 / 腫瘍微小環境 / バイオマーカー / 樹状細胞 / イムノコンプレキソーム

Outline of Final Research Achievements

To elucidate the comprehensive influence on pancreatic cancer tissue and various type of immune cells infiltrating tumor microenvironment to tumor-specific immune system, we analyzed the expression of various tumor immunity-related molecules in pancreatic cancer tissue and peripheral blood sample which were obtained from patients with pancreatic cancer undergoing clinical trials of dendritic cell-based immunotherapy.
As a result, it was revealed that there is a significantly high correlation between infiltration of CD163 positive M2 macrophages and CD66b positive granulocytes in cancer microenvironment with poor prognosis and CD20 positive B cell infiltration as good prognosis. Peripheral blood neutrophil / lymphocyte ratio and serum IL-6 level were also poor prognostic markers. The discovery of this prognosis-associated biomarker may lead to the development of a new composite cancer immunotherapy.

Research Products

• [Journal Article] WT1-pulsed Dendritic Cell Vaccine Combined with Chemotherapy for Resected Pancreatic Cancer in a Phase I Study. (2018)
  • Author(s): Yanagisawa R, Koizumi T, Koya T, Sano K, Koido S, Nagai K, Kobayashi M, Okamoto M, Sugiyama H, Shimodaira S.
  • Journal Title: Anticancer Res. Volume: 38 Issue: 4 Pages: 2217-2225
  • DOI: 10.21873/anticanres.12464
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic significance of Wilms’ tumor 1 expression in patients with pancreatic ductal adenocarcinoma. (2018)
  • Author(s): Kanai T, Ito Z, Oji Y, Suka M, Nishida S, Takakura K, Kajihara M, Saruta M, Fujioka S, Misawa T, Akiba T, Yanagisawa H, Shimodaira S, Okamoto M, Sugiyama H, Koido S.
  • Journal Title: Oncol Lett. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Significance of Wilms' tumor 1 antigen as a cancer vaccine for pancreatic cancer. (2017)
  • Author(s): Koido S, Okamoto M, Kobayashi M, Shimodaira S, Sugiyama H.
  • Journal Title: Discov Med. Volume: 24 Pages: 41-49
  • Peer Reviewed
• [Journal Article] Interferon-alpha-inducible dendritic cells matured with OK-432 exhibit TRAIL and Fas ligand pathway-mediated killer activity. (2017)
  • Author(s): Koya T, Yanagisawa R, Higuchi Y, Sano K, Shimodaira S.
  • Journal Title: Sci Rep. Volume: - Issue: 1 Pages: 42145-42145
  • DOI: 10.1038/srep42145
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic impact of preoperative serum interleukin-6 levels in early stage oral squamous cell carcinoma patients strictly defined by sentinel node biopsy. (2017)
  • Author(s): Goda H, Okamoto M, Nakashiro K, Hino S, Murase R, Hamakawa H
  • Journal Title: Oncol Lett Volume: 14 Pages: 7965-7969
  • DOI: 10.3892/ol.2017.7183
  • Peer Reviewed
• [Journal Article] The donor advocacy team: a risk management program for living organ, tissue, and cell transplant donors. (2017)
  • Author(s): Eguchi S, Soyama A, Nagai K, Miyazaki Y, Kurihara S, Hidaka M, Ono S, Adachi T, Natsuda K, Hara T, Fujita F, Kanetaka K, Takatsuki M.
  • Journal Title: Surg Today Volume: 印刷中 Issue: 8 Pages: 980-985
  • DOI: 10.1007/s00595-017-1468-z
  • Peer Reviewed / Open Access
• [Journal Article] Clinical effect and immunological response in patients with advanced malignant glioma treated with WT1-pulsed dendritic cell-based immunotherapy: A report of two cases. (2017)
  • Author(s): Sakai K, Shimodaira S, Maejima S, Sano K, Higuchi Y, Koya T, Sugiyama H, Hongo K.
  • Journal Title: Interdisciplinary Neurosurgery. Volume: 9 Pages: 24-29
  • DOI: 10.1016/j.inat.2017.02.004
  • Peer Reviewed
• [Journal Article] Peptide-pulsed dendritic cell vaccine in combination with carboplatin and paclitaxel chemotherapy for stage IV melanoma. (2017)
  • Author(s): Fukuda K, Funakoshi T, Sakurai T, Nakamura Y, Mori M, Tanese A, Tanikawa A, Taguchi J, Fujita T, Okamoto M, Amagai M, Kawakami Y.
  • Journal Title: Melanoma Research Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Prognostic impact of preoperative serum interleukin-6 levels in early stage oral squamous cell carcinoma patients strictly defined by sentinel node biopsy. (2017)
  • Author(s): Goda H, Okamoto M, Nakashiro K, Hino S, Murase R, Hamakawa H.
  • Journal Title: Oncol Lett Volume: 印刷中
  • Peer Reviewed
• [Journal Article] No-touch isolation techniques for pancreatic cancer. (2017)
  • Author(s): Kuroki T, Eguchi S.
  • Journal Title: Surg Today. Volume: 47 Pages: 8-13
  • Peer Reviewed / Open Access
• [Journal Article] Lung adenocarcinoma may be a more susceptive subtype to a dendritic cell-based cancer vaccine than other subtypes of non-small cell lung cancers: a multicenter retrospective analysis. (2016)
  • Author(s): Takahashi H, Shimodaira S, Ogasawara M, Ota S, Kobayashi M, Abe H, Morita Y, Nagai K, Tsujitani S, Okamoto M, Suzuki Y, Nakanishi Y, Yonemitsu Y
  • Journal Title: Cancer Immunol Immunother Volume: 65 Issue: 9 Pages: 1099-111
  • DOI: 10.1007/s00262-016-1872-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] WT1 peptide vaccine is unaffected by airport screening X-irradiation. (2016)
  • Author(s): Higuchi Y, Kawakubo M, Yuzawa M, Sano K, Shimodaira S.
  • Journal Title: Austin J Vaccines & Immunother. Volume: 3 Pages: 1010-1010
  • Peer Reviewed
• [Journal Article] Wilms’ tumor 1 (WT1)-targeted cancer vaccines to extend survival for patients with pancreatic cancer. (2016)
  • Author(s): Koido S, Okamoto M, Shimodaira S, Sugiyama H.
  • Journal Title: Immunotherapy Volume: 8 Pages: 1309-20
  • Peer Reviewed
• [Journal Article] Advances in inducing adaptive immunity using cell-based cancer vaccine: Clinical applications in pancreatic cancer. (2016)
  • Author(s): Kajihara M, Takakura K, Kanai T, Ito Z, Matsumoto Y, Shimodaira S, Okamoto M, Ohkusa T, Koido S.
  • Journal Title: World J Gastroenterol Volume: 22 Issue: 18 Pages: 4446-4458
  • DOI: 10.3748/wjg.v22.i18.4446
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dendritic cell-based vaccine for colorectal cancer. (2016)
  • Author(s): Kajihara M, Takakura K, Kanai T, Ito Z, Saito K, Takami S, Shimodaira S, Okamoto M, Ohkusa T, Koido S
  • Journal Title: World J Gastroenterol Volume: 22 Issue: 17 Pages: 4275-4286
  • DOI: 10.3748/wjg.v22.i17.4275
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] An update on dendritic cell-based cancer immunotherapy. (2016)
  • Author(s): Shimodaira S, Hirabayashi K, Koya T, Higuchi Y, Yanagisawa R, Okamoto M, Koido S.
  • Journal Title: Immunome Res. Volume: 12 Issue: 1 Pages: 106-106
  • DOI: 10.4172/1745-7580.10000106
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive assessment of the prognosis of pancreatic cancer: peripheral blood neutrophil-lymphocyte ratio and immunohistochemical analyses of the tumour site. (2016)
  • Author(s): Takakura K, Ito Z, Suka M, Kanai T, Matsumoto Y, Odahara S, Matsudaira H, Haruki K, Fujiwara Y, Saito R, Gocho T, Nakashiro K, Hamakawa H, Okamoto M, Kajihara M, Misawa T, Ohkusa T, Koido S
  • Journal Title: Scand J Gastroenterol Volume: 51 Issue: 5 Pages: 610-7
  • DOI: 10.3109/00365521.2015.1121515
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 癌ワクチンとチェックポイント阻害剤の併用に関する検討 (2016)
  • Author(s): 岡本正人
  • Journal Title: Pharm Stage Volume: 15 Pages: 54-59
• [Journal Article] Human Fibroblast Sheet Promotes Human Pancreatic Islet Survival and Function In Vitro. (2016)
  • Author(s): Matsushima H, Kuroki T, Adachi T, Kitasato A, Ono S, Tanaka T, Hirabaru M, Kuroshima N, Hirayama T, Sakai Y, Soyama A, Hidaka M, Takatsuki M, Kin T, Shapiro J, Eguchi S.
  • Journal Title: Cell Transplant. Volume: 25 Issue: 8 Pages: 1525-37
  • DOI: 10.3727/096368916x690854
  • NAID: 120006987668
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of dendritic cell-based cancer immunotherapy. (2016)
  • Author(s): Shimodaira S, Higuchi Y, Yanagisawa R, Okamoto M, Koido S.
  • Journal Title: Biochem & Anal Biochem Volume: in press Pages: 240-240
  • Peer Reviewed
• [Journal Article] Standard WT1 expression using immunohistochemistry. (2016)
  • Author(s): Shimodaira S, Hirabayashi K, Koya T, Higuchi Y, Sano K
  • Journal Title: Mol Biomark Diagn Volume: in press Pages: 1-1
  • Peer Reviewed
• [Journal Article] Quality verification of dendritic cell-based cancer vaccine. (2016)
  • Author(s): Shimodaira S, Koya T, Higuchi Y, Okamoto M, Koido S.
  • Journal Title: Pharm Anal Acta Volume: in press Pages: 465-465
  • Peer Reviewed
• [Journal Article] Dendritic cell-based vaccine for pancreatic cancer in Japan. (2016)
  • Author(s): Okamoto M, Kobayashi M, Yonemitsu Y, Koido S, Homma S
  • Journal Title: World J Gastrointest Pharmacol Ther Volume: 7 Issue: 1 Pages: 133-8
  • DOI: 10.4292/wjgpt.v7.i1.133
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] No-touch isolation techniques for pancreatic cancer. (2016)
  • Author(s): Kuroki T, Eguchi S.
  • Journal Title: Surg Today. Volume: in press Pages: 1-6
  • Peer Reviewed
• [Journal Article] Dendritic Cell-Based Adjuvant Vaccination Targeting Wilms' Tumor 1 in Patients with Advanced Colorectal Cancer (2015)
  • Author(s): 下平 滋隆, 湯沢 美紀, 他
  • Journal Title: Vaccines Volume: 3 Issue: 4 Pages: 1004-1018
  • DOI: 10.3390/vaccines3041004
  • Peer Reviewed / Open Access
• [Journal Article] Safety and tolerability of allogeneic dendritic cell vaccination with induction of WT1-specific T cells in a pediatric donor and pediatric patient with relapsed leukemia: A case report and review of the literature. (2015)
  • Author(s): Saito S, Yanagisawa R, Yoshikawa K, Higuchi Y, Koya T, Yoshizawa K, Tanaka M, Sakashita K, Kobayashi T, Kurata T, Hirabayashi K, Nakazawa Y, Shiohara M, Yonemitsu Y, Okamoto M, Sugiyama S, Koike K, Shimodaira S.
  • Journal Title: Cytotherapy Volume: 17 Issue: 3 Pages: 330-335
  • DOI: 10.1016/j.jcyt.2014.10.003
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dendritic cell-based immunotherapy targeting Wilms' Tumor 1 (WT1) in patients with relapsed malignant glioma. (2015)
  • Author(s): Sakai K, Shimodaira S, Maejima S, Udagawa N, Sano K, Higuchi Y, Koya T, Ochiai T, Koide M, Uehara S, Nakamura M, Sugiyama H, Yonemitsu Y, Okamoto M, Hongo K.
  • Journal Title: J Neurosurg Volume: 123 Issue: 4 Pages: 989-997
  • DOI: 10.3171/2015.1.jns141554
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic significance of plasma interleukin-6/-8 in pancreatic cancer patients receiving chemoimmunotherapy. (2015)
  • Author(s): Tsukinaga S, Kajihara M, Takakura K, Ito Z, Kanai T, Saito K, Takami S, Kobayashi H, Matsumoto Y, Odahara S, Uchiyama K, Arakawa H, Okamoto M, Sugiyama H, Sumiyama K, Ohkusa T, Koido S
  • Journal Title: World J Gastroenterol Volume: 21 Issue: 39 Pages: 11168-78
  • DOI: 10.3748/wjg.v21.i39.11168
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Phase I pilot study of Wilms tumor gene 1 peptide-pulsed dendritic cell vaccination combined with gemcitabine in pancreatic cancer. (2015)
  • Author(s): Mayanagi S, Kitago M, Sakurai T, Matsuda T, Fujita T, Higuchi H, Taguchi J, Takeuchi H, Itano O, Aiura K, Hamamoto Y, Takaishi H, Okamoto M, Sunamura M, Kawakami Y, Kitagawa Y.
  • Journal Title: Cancer Science Volume: 106 Issue: 4 Pages: 397-406
  • DOI: 10.1111/cas.12621
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Laparoscopic distal pancreatosplenectomy for pancreatic ductal adenocarcinoma. (2015)
  • Author(s): Kuroki T, Eguchi S.
  • Journal Title: Surg Today. Volume: 45 Issue: 7 Pages: 808-812
  • DOI: 10.1007/s00595-014-1021-2
  • Peer Reviewed / Open Access
• [Journal Article] Increased expression of PHD3 represses the HIF-1 signaling pathway and contributes to poor neovascularization in pancreatic ductal adenocarcinoma. (2015)
  • Author(s): Tanaka T, Li TS, Urata Y, Goto S, Ono Y, Kawakatsu M, Matsushima H, Hirabaru M, Adachi T, Kitasato A, Takatsuki M, Kuroki T, Eguchi S.
  • Journal Title: J Gastroenterol. Volume: 50 Issue: 9 Pages: 975-83
  • DOI: 10.1007/s00535-014-1030-3
  • NAID: 120006986909
  • Peer Reviewed / Open Access
• [Journal Article] A Method for Performing Islet Transplantation Using Tissue-Engineered Sheets of Islets and Mesenchymal Stem Cells. (2015)
  • Author(s): Hirabaru M, Kuroki T, Adachi T, Kitasato A, Ono S, Tanaka T, Matsushima H, Sakai Y, Soyama A, Hidaka M, Yamanouchi K, Takatsuki M, Okano T, Eguchi S.
  • Journal Title: Tissue Eng Part C Methods. Volume: 21 Issue: 12 Pages: 1205-15
  • DOI: 10.1089/ten.tec.2015.0035
  • Peer Reviewed
• [Journal Article] Sox9 expression in carcinogenesis and its clinical significance in intrahepatic cholangiocarcinoma. (2015)
  • Author(s): Matsushima H, Kuroki T, Kitasato A, Adachi T, Tanaka T, Hirabaru M, Hirayama T, Kuroshima N, Hidaka M, Soyama A, Takatsuki M, Kinoshita N, Sano K, Nishida N, Eguchi S.
  • Journal Title: Dig Liver Dis. Volume: 47 Issue: 12 Pages: 1067-75
  • DOI: 10.1016/j.dld.2015.08.003
  • Peer Reviewed / Open Access
• [Presentation] IFN-alpha; inducible dendritic cells matured with OK-432 exhibit professional antigen-presentation and anti-tumor activity. (2017)
  • Author(s): Koya T, Shimodaira S.
  • Organizer: 5th Annual Meeting of the International Cytokine & Interferon Society.
  • Int'l Joint Research
• [Presentation] がん免疫療法におけるバイオマーカーの開発（２） (2017)
  • Author(s): 岡本 正人、小井戸 薫雄、金井 友哉、西田 純幸、尾路 祐介、杉山 治夫
  • Organizer: 第30回日本バイオセラピィ学会学術集会総会
• [Presentation] 膵臓癌患者におけるウィルムス腫瘍遺伝子（WT1）発現の臨床的意義 (2017)
  • Author(s): 金井 友哉、伊藤 善翔、尾路 祐介、西田 純幸、高倉 一樹、梶原 幹生、藤岡 秀一、三澤 健介、秋葉 直志、柳澤 裕之、猿田 雅之、岡本 正人、杉山 治夫、小井戸 薫雄
  • Organizer: JDDW2017 第25回日本消化器関連学会週間
• [Presentation] 口腔扁平上皮癌のバイオマーカーIL-6～治療標的としての可能性を探る～ (2017)
  • Author(s): 岡本 正人、合田 啓之、中城 公一、浜川 裕之
  • Organizer: 第26回日本癌病態治療研究会
• [Presentation] 口腔扁平上皮癌微小環境における免疫パラメーターと予後～治療標的になりうるか？～ (2017)
  • Author(s): 岡本 正人、合田 啓之、中城 公一、浜川 裕之
  • Organizer: 第38回癌免疫外科研究会
• [Presentation] がん免疫療法最前線～がんワクチン、チェックポイント阻害剤、免疫細胞治療～ (2017)
  • Author(s): 岡本 正人
  • Organizer: 第71回NPO法人日本口腔科学会学術集会
• [Presentation] 樹状細胞がんワクチン～Bench to Bedside～ (2017)
  • Author(s): 岡本 正人
  • Organizer: 第71回NPO法人日本口腔科学会学術集会
• [Presentation] がん微小環境におけるIL-8関連免疫抑制細胞の役割～膵癌と口腔癌～ (2016)
  • Author(s): 岡本正人、高倉一樹、合田啓之、中城公一、小井戸薫雄、浜川裕之
  • Organizer: 第29回日本バイオセラピィ学会学術集会総会
  • Place of Presentation: 久留米シティプラザ（福岡県・久留米市）
  • Year and Date: 2016-12-01
• [Presentation] 樹状細胞ワクチンを投与された非小細胞肺癌患者260例の解析と化学療法併用における免疫チェックポイント分子の意義 (2016)
  • Author(s): 岡本正人、高橋秀徳、下平滋隆、小笠原正浩、小林正学、阿部浩文、森田祐二、長井一浩、辻谷俊一、米満吉和
  • Organizer: 第29回日本バイオセラピィ学会学術集会総会
  • Place of Presentation: 久留米シティプラザ（福岡県・久留米市）
  • Year and Date: 2016-12-01
• [Presentation] 遠隔転移を認めるIV期癌の治療戦略 進行癌に対するがん免疫療法の展開 免疫チェックポイント阻害薬と樹状細胞ワクチン (2016)
  • Author(s): 辻谷 俊一, 下平 滋隆, 岡本 正人, 米満 吉和, 小笠原 正浩, 長井 一浩, 小井戸 薫雄, 小林 正学
  • Organizer: 第54回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-10-20
• [Presentation] 口腔扁平上皮癌における予後予測因子としてのバイオマーカーの探索 (2016)
  • Author(s): 合田啓之、岡本正人、中城公一、浜川裕之
  • Organizer: 第 54 回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-10-20
• [Presentation] 局所進行膵癌に対するオーダーメードの治療戦略 術前治療から術後補助療法まで (2016)
  • Author(s): 北里 周, 黒木 保, 大野 慎一郎, 黒島 直樹, 平山 昂仙, 川上 悠介, 今村 一歩, 岡田 怜美, 夏田 孔史, 曽山 明彦, 日高 匡章, 長井 一浩, 江口 晋
  • Organizer: 第28回日本肝胆膵外科学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府・大阪市）
  • Year and Date: 2016-06-02
• [Presentation] 化学療法による免疫抑制解除～Th1誘導とチェックポイント阻害～ (2016)
  • Author(s): 岡本正人、合田啓之、中城公一、浜川裕之
  • Organizer: 第37回癌免疫外科研究会
  • Place of Presentation: 川越プリンスホテル（埼玉県・川越市）
  • Year and Date: 2016-05-12
• [Presentation] 口腔癌に対する樹状細胞ワクチン療法～全身投与と局所投与～ (2016)
  • Author(s): 岡本正人
  • Organizer: 第37回癌免疫外科研究会
  • Place of Presentation: 川越プリンスホテル（埼玉県・川越市）
  • Year and Date: 2016-05-12
• [Presentation] 口腔癌と膵癌における免疫バイオマーカー～末梢と癌局所～ (2016)
  • Author(s): 岡本正人、高倉一樹、小井戸薫雄、合田啓之、中城公一、浜川裕之
  • Organizer: 第37回癌免疫外科研究会
  • Place of Presentation: 川越プリンスホテル（埼玉県・川越市）
  • Year and Date: 2016-05-12
• [Presentation] 口腔扁平上皮癌におけるInterleukin-6 シグナルを標的とした治療アプローチの検討 (2016)
  • Author(s): 合田啓之、岡本正人、中城公一、徳善紀彦、浜川裕之
  • Organizer: 第70 回 NPO 法人日本口腔科学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡県・福岡市）
  • Year and Date: 2016-04-15
• [Presentation] Dendritic cell-based cancer immunotherapy. (2016)
  • Author(s): Shimodaira S.
  • Organizer: the 20th Annual Meeting of TAPAAI: New Era of Precision Medicien on Allergy and Immunology.
  • Place of Presentation: Taipei（Taiwan）
  • Int'l Joint Research / Invited
• [Presentation] Dendritic cell-based cancer vaccination technology: future prospective. (2016)
  • Author(s): Shimodaira S.
  • Organizer: BIT’s 6th Annual World Congress of Molecular & Cell Biology 2016.
  • Place of Presentation: Dalian（China）
  • Int'l Joint Research / Invited
• [Presentation] Cancer vaccination with peptide and dendritic cell targeting Wilms’Tumor 1. (2016)
  • Author(s): Shimodaira S.
  • Organizer: BIT’s 9th Annual World Protein & Peptide Conference-2016.
  • Place of Presentation: Dalian（China）
  • Int'l Joint Research / Invited
• [Presentation] 樹状細胞免疫療法が有効であったHIVキャリアに発症した細胆管癌の一症例 (2016)
  • Author(s): 長井一浩
  • Organizer: 第5回 日本免疫・細胞治療学会 学術集会
  • Place of Presentation: 秋葉原UDX（東京都・千代田区）
• [Presentation] IL-8～口腔扁平上皮癌のバイオマーカー (2016)
  • Author(s): 岡本正人
  • Organizer: 第5回 日本免疫・細胞治療学会 学術集会
  • Place of Presentation: 秋葉原UDX（東京都・千代田区）
• [Presentation] Anti-interleukin 6 receptor antibody suppressed oral squamous cell carcinoma by inhibiting tumor-stroma interaction. (2015)
  • Author(s): Goda H, Okamoto M, Nakashiro K, Tozuka N, Hamakawa H.
  • Organizer: ESMO Asia 2015 Congress
  • Place of Presentation: Suntec Singapore Convention & Exhibition Center, Singapore
  • Year and Date: 2015-12-18
  • Int'l Joint Research
• [Presentation] 治癒切除後膵臓癌に対するWT1およびMUC1ペプチドパルス樹状細胞免疫療法の術後アジュバント療法としての有用性 (2015)
  • Author(s): 長井一浩、北里 周、原田 浩、足立智彦、黒木 保、岡本正人、宮崎泰司、江口 晋
  • Organizer: 第28回日本バイオセラピー学会総会
  • Place of Presentation: 川越東武ホテル，埼玉県川越市
  • Year and Date: 2015-12-03
• [Presentation] 癌炎症病態の解明とそのバイオマーカーとしての意義～末梢血と癌微小環境 (2015)
  • Author(s): 岡本正人、藤田知信、野路しのぶ、南雲春菜、桜井敏晴、合田啓之、中城公、浜川裕之、河上裕
  • Organizer: 第28回日本バイオセラピー学会総会
  • Place of Presentation: 川越東武ホテル，埼玉県川越市
  • Year and Date: 2015-12-03
• [Presentation] 進行期非小細胞肺癌患者に対する樹状細胞ワクチンによる臨床的有用性および予後因子の検討：多施設共同研究 (2015)
  • Author(s): 高橋秀徳、下平滋隆、小笠原正浩、小林正学、阿部浩文、長井一浩、岡本正人、辻谷俊一、森田祐二、米満吉和
  • Organizer: 第28回日本バイオセラピー学会総会
  • Place of Presentation: 川越東武ホテル，埼玉県川越市
  • Year and Date: 2015-12-02
• [Presentation] Dual role of soluble IL2Ralpha as a biomarker for cancer immunotherapy (2015)
  • Author(s): Nagumo H, Fujita T, Sakurai T, Noji S, Okamoto M, Matsueda S, Sasada T, Itoh K, Kawakami Y.
  • Organizer: 第44回日本免疫学会学術集会
  • Place of Presentation: 札幌コンベンションセンター，北海道
  • Year and Date: 2015-11-18
• [Presentation] Dendritic cell-based Cancer Immunotherapy. (2015)
  • Author(s): Shimodaira S
  • Organizer: 3rd International Conference on Hematology & Blood Disorders.
  • Place of Presentation: Atlanta, US
  • Year and Date: 2015-11-02
  • Int'l Joint Research / Invited
• [Presentation] Development of dendritic cell-based cancer vaccine in Japan. (2015)
  • Author(s): Okamoto M.
  • Organizer: International Conference on Vaccine R&D 2015
  • Place of Presentation: The Double Tree by Hilton Baltimore BWI Airport, Baltimore, MD, USA
  • Year and Date: 2015-11-02
  • Int'l Joint Research / Invited
• [Presentation] Phase I/II pilot study of peptide-pulsed dendritic cell vaccination in combination with carboplatin and paclitaxel chemotherapy for stage IV melanoma. (2015)
  • Author(s): Fukuda K, Funakoshi T, Sakurai T, Nakamura Y, Mori M, Tanikawa A, Fujita T, Taguchi J, Okamoto M, Amagai M, Kawakami Y.
  • Organizer: International Conference of Cancer Immunotherapy and Macrophages 2015
  • Place of Presentation: The University of Tokyo, Tokyo
  • Year and Date: 2015-07-09
  • Int'l Joint Research
• [Presentation] Prognostic significance of interleukin-8 and infiltration of immune cells positive for CD163 and CD66b in tumor tissues in patients with oral squamous cell carcinoma. (2015)
  • Author(s): Okamoto M, Fujita Y, Goda H, Hakashiro K, Hamakawa H
  • Organizer: AACR Annual Meeting 2015
  • Place of Presentation: Pennsylvania Convention Center, Philadelphia, PA, USA
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Book] バイオロジカルクリーンルームの設計・維持管理と作業教育 (2018)
  • Author(s): 下平 滋隆，小屋 照継，石垣 靖人（分担）
  • Total Pages: 541
  • Publisher: 技術情報協会
  • ISBN: 4861046955
• [Book] ペプチド医薬品のスクリーニング・安定化・製剤化技術 (2017)
  • Author(s): 岡本 正人、小井戸 薫雄、下平 滋隆、杉山 治夫（分担）
  • Total Pages: 558
  • Publisher: 技術情報協会
  • ISBN: 4861046874
• [Book] Wilms Tumor: Chapter 8 Dendritic Cell-Based Cancer Immunotherapy Targeting Wilms’ Tumor 1 for Pediatric Cancer. (2016)
  • Author(s): Shimodaira S, Hirabayashi K, Yanagisawa R, Higuchi Y, Sano K, Koizumi T.
  • Total Pages: 294
  • Publisher: Codon Publications (Brisbane, Australia)
• [Book] Wilms’ Tumor (2016)
  • Author(s): Shimodaira S, Hirabayashi K, Yanagisawa R, Higuchi Y, Sano K, Koizumi T.
  • Total Pages: 293
  • Publisher: Codon Publications (Brisbane, Australia)
• [Book] Immunotherapy of Cancer: An Innovative Treatment Comes of Age (2016)
  • Author(s): Okamoto M
  • Total Pages: 358
  • Publisher: Springer Japan KK
• [Patent(Industrial Property Rights)] G-CSFを用いた樹状細胞の調製方法 (2018)
  • Inventor(s): 下平 滋隆, 小屋 照継, 樋口 由美子
  • Industrial Property Rights Holder: 下平 滋隆, 小屋 照継, 樋口 由美子
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018