Comprehensive diagnosis of bacterial infection associated with acute cholecystitis using metagenomic approach
| Project/Area Number |
15K10198
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Toho University |
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Principal Investigator |
ASAI Koji 東邦大学, 医学部, 講師 (20366454)
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| Co-Investigator(Kenkyū-buntansha) |
草地 信也 東邦大学, 医学部, 教授 (70169978)
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| Co-Investigator(Renkei-kenkyūsha) |
KURODA Makoto 国立感染症研究所, 病原体ゲノム解析研究センター, センター長 (80317411)
MATSUMOTO Tetsuya 東京医科大学, 医学部, 教授 (10256688)
MAETANI Iruru 東邦大学, 医学部, 教授 (00219263)
WATANABE Manabu 東邦大学, 医学部, 准教授 (30297709)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 急性胆道炎 / メタゲノム解析 / 抗菌薬感受性 / 耐性菌 / 抗菌薬感受性検査 / 多剤耐性菌 / 急性胆管炎 / 急性胆嚢炎 |
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| Outline of Final Research Achievements |
We undertook a metagenomic approach to characterize the bacterial infection associated with acute cholecystitis and cholangitis. More than 100 cases included this analyses during 3 years. Metagenomic analysis demonstrated possible single or multiple bacteria infections within 24 h. Also, antimicrobial resistance including extended-spectrum beta-lactamase gene could be identified in other 24 h. Metagenomic analysis was useful for rapid bacterial diagnosis including assessing potential antimicrobial susceptibility in patients with acute cholecystitis and cholangitis.
We have already reported preliminary 6 cases（Kujiraoka M, Front Microbial 2017）. Now, we prepare to report total analytic cases.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Comprehensive Diagnosis of Bacterial Infection Associated with Acute Cholecystitis Using Metagenomic Approach2017
Author(s)
Kujiraoka M, Kuroda M, Asai K, Sekizuka T, Kato K, Watanabe M, Matsukiyo H, Saito T, Ishii T, Katada N, Saida Y, Kusachi S
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Journal Title
Frontiers in Microbiology
Volume: -
DOI
Related Report
Peer Reviewed
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[Presentation] Appropriate timing of laparoscopic surgery for acute cholecystitis using propensity score matching2016
Author(s)
Asai K, Watanabe M, Matsukiyo H, Saito T, Ishii T, Enomoto T, Kiribayashi T, Nakamura Y, Katada N, Saida Y, Kusachi S
Organizer
40th World Congress of the International College of Surgeons
Place of Presentation
京都国際会議場（京都府京都市）
Year and Date
2016-10-25
Related Report
Int'l Joint Research
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[Presentation] Risk factors for conversion of laparoscopic cholecystectomy to open surgery associated with the severity characteristics according to the Tokyo Guidelines2016
Author(s)
Asai K, Watanabe M, Matsukiyo H, Saito T, Ishii T, Kiribayashi T, Enomoto T, Nakamura Y, Katada N, Saida Y, Kusachi S
Organizer
26th World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists
Place of Presentation
Seoul (Korea)
Year and Date
2016-09-08
Related Report
Int'l Joint Research
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[Presentation] What is the best practice management for patients with acute cholecystitis?2016
Author(s)
Asai K, Watanabe M, Matsukiyo H, Saito T, Ishii T, Watanabe R, Enomoto T, Katada N, Saida Y, Kusach S
Organizer
SAGES 2016
Place of Presentation
Hynes Veterans Memorial Convention Center (Boston, MA, USA)
Year and Date
2016-03-17
Related Report
Int'l Joint Research
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[Presentation] 急性胆嚢炎の手術時期別に見た治療成績の検討2015
Author(s)
浅井浩司，渡邉 学，松清 大，齋藤智明，斉田芳久，草地信也，他
Organizer
第13回日本消化器外科学会大会（JDDW 2015）
Place of Presentation
グランドプリンスホテル新高輪国際館パミール（東京都港区）
Year and Date
2015-10-10
Related Report
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[Presentation] Laparoscopic distal pancreatectomy for giant pancreatic mucinous cystic neoplasm using SAND balloon catheter2015
Author(s)
Asai K, Watanabe M, Matsukiyo H, Saito T, Ishii T, Kujiraoka M, Watanabe R, Enomoto T, Saida Y, Kusachi S
Organizer
The 12th Asia-Pacific Congress of Endoscopic and Laparoscopic Surgery
Place of Presentation
EXCO (Daegu, Korea)
Year and Date
2015-09-05
Related Report
Int'l Joint Research
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