The role of Sulfatase in cholangioma
| Project/Area Number |
15K10200
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
NAKAMURA IKUO 兵庫医科大学, 医学部, 講師 (10625312)
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| Co-Investigator(Kenkyū-buntansha) |
藤元 治朗 兵庫医科大学, 医学部, 教授 (90199373)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 胆管細胞癌 / Sulfatase / 癌増殖 / EMT / sulfatase |
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| Outline of Final Research Achievements |
We have reported that Sulfatase (SULF) plays an important role in tumor growth and invasion in hepatocellular carcinoma (HCC). The expression of SULF in cholangioma was also found. The aim of this study is to investigate the effect of SULF on tumor growth and invasion in cholangioma and to apply it to the clinical treatment. In this study, we found and quantified the expression of SULF1 and SULF2 in the resected specimens of the patients with intrahepatic cholangiocellular carcinoma (ICC) by immunohistochemistory. Although the expression of SULF2 was not related to the outcome in patients with ICC, low expression of SULF1 showed poor prognosis in recurrence free survival and overall survival.SULF1 could be useful as a tumor marker for cholangioma.
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Report
(4 results)
Research Products
(1 results)
