| Project/Area Number |
15K10201
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
栗林 太 川崎医科大学, 医学部, 教授 (60251443)
山村 真弘 川崎医科大学, 医学部, 講師 (70299204)
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| Co-Investigator(Renkei-kenkyūsha) |
Nakamura Masafumi 九州大学, 医学部, 教授 (30372741)
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| Research Collaborator |
Sakaguchi Masakiyo 岡山大学, 大学院・医歯薬学総合研究科, 准教授
Katase Naoki 長崎大学, 大学院・医歯薬学総合研究科, 助教
Itadaini Masumi 川崎医科大学, 医学部, 実験補助員
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 転移惹起因子 / 走化性 / 遊走 / がん / 癌転移 / 膵癌 / 血清因子 / 脂質 |
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| Outline of Final Research Achievements |
Pancreatic cancer is one of the diseases with poorest prognosis, which needs urgent countermeasures. Serum is known to be a strong chemoattractant, however, particular factors which cause cancer cell migration or metastasis remain unknown because of its heterogeneity. In this project, we explored the unknown factors which attract cancer cells, i.e. the metastasis promoting factors. At first, we established the evaluation system for cancer cell migration. Next, we found such factors in the non-protein, hydrophobic, and low-molecular-weight fraction. Also we found S100 proteins, known as factors produced in inflammation sites, as such factors. We are now evaluating these factors with animal model and with patients’ samples.
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