The significance of c-myc expression in pancreatic cancer

• Project/Area Number: 15K10203
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Osaka International Cancer Institute
• Principal Investigator: Hirofumi Akita 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 医長 (70528463)
• Co-Investigator(Kenkyū-buntansha): 永野 浩昭 山口大学, 大学院医学系研究科, 教授 (10294050) ; 後藤 邦仁 大阪大学, 医学(系)研究科(研究院), 助手 (10362716) ; 小林 省吾 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 副部長 (30452436) ; 高橋 秀典 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 副部長 (90601120)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 膵臓癌 / c-myc / 癌幹細胞 / 予後 / 膵癌 / 抗癌剤耐性 / 放射線耐性 / 幹細胞

Outline of Final Research Achievements

The mild stimulation of c-myc by using tet-myc activation system lead pancreatic cancer cell lines to spindle-like cells, increasing the spheroid formation ability and tumorigenesis potential. However, when exceeding a threshold level, c-MYC induced loss of proliferation potential and a pro-apoptotic program. Next we examined the relationship between c-myc expression and clinical outcome after radical resection by using 65 pancreatic cancer patients. Patients with high c-myc expression showed a significantly worse prognosis both in overall survival and disease-free survival(p<0.001, p=0.003). In 45 patients with preoperative chemoradiotherapy, there was no significant difference between c-myc expression and pathological effect. In conclusion, c-myc could be related to the maintenance of cancer stem cell in pancreatic cancer and high c-myc expression in pancreatic cancer showed poor prognosis with showing the resistance of preoperative chemoradiotherapy.

Research Products

• [Journal Article] The POU5F1 gene expression in colorectal cancer: a novel prognostic marker (2018)
  • Author(s): Miyoshi N, Fujino S, Ohue M, Yasui M, Takahashi Y, Sugimura K, Tomokuni A, Akita H, Kobayashi S, Takahashi H, Omori T, Miyata H, Yano M
  • Journal Title: Surgery Today Volume: in press Pages: 709-715
  • DOI: 10.1007/s00595-018-1644-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 18F-fluorodeoxyglucose positron emission tomography/computed tomography for the prediction of survival in patients with advanced esophageal cancer who have undergone neoadjuvant chemotherapy. (2018)
  • Author(s): Yano M, Miyata H, Sugimura K, Motoori M, Omori T, Fujiwara Y, Miyoshi N, Yasui M, Ohue M, Akita H, Tomokuni A, Takahashi H, Kobayashi S, Sakon M
  • Journal Title: Mol Clin Oncol Volume: 8(3) Pages: 434-440
  • DOI: 10.3892/mco.2018.1546
  • Peer Reviewed
• [Journal Article] Laparoscopic Hilar Lymph Node Sampling in Patients With Biliary Tract Cancers That are Rarely Associated With Nodal Metastasis. (2018)
  • Author(s): Kobayashi S, Tomokuni A, Takahashi H, Akita H, Marubashi S, Gotoh K, Yanagimoto Y, Takahashi T, Sugimura K, Miyorhi N, Moon JH, Yasui M, Omori T, Miyata T, Ohue M, Fujiwara Y, Yano M, Sakon M.
  • Journal Title: Surg Laparosc Endosc Percutan Tech. Volume: 28 Pages: 90-95
  • DOI: 10.1097/sle.0000000000000510
  • Peer Reviewed
• [Journal Article] The Clinical Significance of Alpha-Fetoprotein mRNAs in Patients with Hepatocellular Carcinoma. (2017)
  • Author(s): Kobayashi S, Tomokuni A, Takahashi H, Akita H, Sugimura K, Miyoshi N, Moon JH, Yasui M, Omori T, Ohue M, Fujiwara Y, Yano M, Sakon M.
  • Journal Title: Gastrointest Tumors Volume: 3 Pages: 141-152
  • DOI: 10.1159/000455955
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Assessment of Sarcopenia and Changes in Body Composition During Neoadjuvant Chemotherapy for Esophageal Cancer. (2017)
  • Author(s): Miyata H, Sugimura K, Motoori M, Fujiwara Y, Omori T, Yanagimoto Y, Ohue M, Yasui M, Miyoshi N, Tomokuni A, Akita H, Kobayashi S, Takahashi H, Yano M
  • Journal Title: Anticancer Res. Volume: 37(6) Pages: 3053-3059
  • Peer Reviewed
• [Journal Article] FDG-PET predicts treatment efficacy and surgical outcome of pre-operative chemoradiation therapy for resectable and borderline resectable pancreatic cancer. (2017)
  • Author(s): Akita H, Takahashi H, Ohigashi H, Tomokuni A, Kobayashi S, Sugimura K, Miyoshi N, Moon JH, Yasui M, Omori T, Miyata H, Ohue M, Fujiwara Y, Yano M, Ishikawa O, Sakon M.
  • Journal Title: Eur J Surg Oncol Volume: 43(6) Pages: 1061-1067
  • DOI: 10.1016/j.ejso.2017.03.015
  • Peer Reviewed
• [Journal Article] Metastatic mixed acinar-endocrine carcinoma of the pancreas treated with a multidisciplinary approach: a case report (2017)
  • Author(s): Hara T, Fujiwara Y, Takahashi H, Sugimura K, Moon JH, Omori T, Miyoshi N, Tomokuni A, Akita H, Kobayashi S, Yasui M, Miyata H, Ohue M, Sakon M, Tomita Y, Yano M.
  • Journal Title: Surg Case Rep Volume: 3(1) Pages: 51-51
  • DOI: 10.1186/s40792-017-0326-y
  • Peer Reviewed
• [Journal Article] Novel intraoperative use of the "Tensipresser" to assess factors predictive of pancreatic fistula after pancreaticoduodenectomy. (2017)
  • Author(s): Mikamori M, Gotoh K, Takahashi H, Akita H, Tomokuni A, Kobayashi S, Ohue M, Fujiwara Y, Yano M, Ishikawa O, Sakon M
  • Journal Title: Surg Today. Volume: 47(10) Pages: 1201-1207
  • DOI: 10.1007/s00595-017-1509-7
  • Peer Reviewed
• [Journal Article] A retrospective analysis of the clinical effects of neoadjuvant combination therapy with full-dose gemcitabine and radiation therapy in patients with biliary tract cancer. (2017)
  • Author(s): Kobayashi S, Tomokuni A, Gotoh K, Takahashi H, Akita H, Marubashi S, Yamada T, Teshima T, Fukui K, Fujiwara Y, Sakon M.
  • Journal Title: Eur J Surg Oncol. Volume: 43 Pages: 736-771
  • DOI: 10.1016/j.ejso.2016.12.008
  • Peer Reviewed
• [Journal Article] 19. Prognostic Significance of Basing Treatment Strategy on the Results of Photodynamic Diagnosis in Advanced Gastric Cancer. (2017)
  • Author(s): Ushimaru Y, Fujiwara Y, Kishi K, Sugimura K, Omori T, Moon JH, Yanagimoto Y, Ohue M, Yasui M, Takahashi H, Kobayashi S, Akita H, Miyoshi N, Tomokuni A, Sakon M, Yano M.
  • Journal Title: Ann Surg Oncol. Volume: 24(4) Pages: 983-989
  • DOI: 10.1245/s10434-016-5660-y
  • Peer Reviewed
• [Journal Article] Endoscopic marking clip with an IC tag and receiving antenna to detect localization during laparoscopic surgery. (2017)
  • Author(s): Wada Y., Takahashi H., et al.
  • Journal Title: Surg Endosc Volume: Oct 31 Pages: 3056-3060
  • DOI: 10.1007/s00464-016-5303-1
  • Peer Reviewed