Elucidation of acquired von Willebrand syndrome in cases with mechanical circulation support

• Project/Area Number: 15K10204
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Tohoku University
• Principal Investigator: Fujiwara Hidenori 東北大学, 医学系研究科, 非常勤講師 (20747117)
• Co-Investigator(Kenkyū-buntansha): 齋木 佳克 東北大学, 医学系研究科, 教授 (50372298) ; 秋山 正年 東北大学, 大学病院, 講師 (80526450) ; 河津 聡 東北大学, 大学病院, 助教 (80633685)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: von Willebrand factor / 後天性von Willebrand症候群 / 補助人工心臓 / 出血合併症 / vWF large multimer Index / 消化管出血 / Shear stress / ADAMTS13 / 後天性フォンウィルブランド症候群 / 植込型補助人工心臓 / vWF large multimer index / 後天性von Willebrand 症候群 / 機械的補助循環 / multimer解析 / shear stress

Outline of Final Research Achievements

In this study, we first established methodology of a hematological severity of acquired von Willebrand syndrome. Using this, we examined 41 patients after implanted left ventricular assist device, clarified the relationship between the hematological severity of acquired von Willebrand syndrome and gastrointestinal bleeding. Another purpose of this study was to develop the method to predict hematological severity of acquired von Willebrand syndrome. We newly developed a shear-stressor for blood and established a method for predicting the hematological severity of acquired von Willebrand syndrome, and filed a patent application.

Research Products

• [Journal Article] Association between severity of acquired von Willebrand syndrome and gastrointestinal bleeding after continuous flow left ventricular assist device implantation (2018)
  • Author(s): Ko Sakatsume, Kenki Saito, Masatoshi Akiyama, Konosuke Sasaki, Satoshi Kawatsu, Goro Takahashi, Osamu Adachi, Shunsuke Kawamoto, Hisanori Horiuchi, Yoshikatsu Saiki
  • Journal Title: European Journal of Cardio-Thoracic Surgery Volume: -
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Intractable bleeding tendency due to acquired von Willebrand syndrome after Jarvik 2000 implant. (2016)
  • Author(s): Sakatsume K, Akiyama M, Saito K, Kawamoto S, Horiuchi H, Saiki Y.
  • Journal Title: Journal of Artificial Organs Volume: - Issue: 3 Pages: 1-4
  • DOI: 10.1007/s10047-016-0896-7
  • Peer Reviewed
• [Presentation] vWF large multimer index could be a predictive value of gastrointestinal bleedings after LVAD implantation (2018)
  • Author(s): Ko Sakatsume, Masatoshi Akiyama, Yusuke Suzuki, Satoshi Kawatsu, Ichiro Yoshioka, Goro Takahashi, Kiichiro Kumagai, Osamu Adachi, Hisanori Horiuchi, Yoshikatsu Saiki
  • Organizer: 第８２回日本循環器学会
• [Presentation] Acquired von Willebrand Syndrome in Patients with Implantable Left Ventricular Assist Device (2016)
  • Author(s): Ko Sakatsume, Masatoshi Akiyama, Kenki Saito, Ichiro Yoshioka, Shinya Masuda, Hidenori Fujiwara,Osamu Adachi, Kiichiro Kumagai, Shunsuke Kawamoto, Hisanori Horiuchi, Yoshikatsu Saiki
  • Organizer: 第80回日本循環器学会総会
  • Place of Presentation: 仙台国際センター（仙台市）
  • Year and Date: 2016-03-18
• [Presentation] 植込型補助人工心臓における出血合併症-後天性フォンウィルブランド症候群の定量的評価- (2016)
  • Author(s): 坂爪 公、秋山正年、斎藤健貴、川本俊輔、堀内久徳、齋木佳克
  • Organizer: 第44回人工心臓と補助循環懇話会学術集会
  • Place of Presentation: ホテル松島大観荘（松島町）
  • Year and Date: 2016-03-04
• [Presentation] Bleeding complications after LVAD implantation -Quantitative method of acquired von Willebrand syndrome- (2016)
  • Author(s): Ko Sakatsume, Masatoshi Akiyama,Kiichiro Kumagai, Shunsuke Kawamoto, Hisanori Horiuchi, Yoshikatsu Saiki
  • Organizer: 第46回日本心臓血管外科学会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2016-02-15
• [Presentation] 植込み型補助人工心臓における後天性フォンウィルブランド病 (2016)
  • Author(s): 坂爪公
  • Organizer: 第38回日本血栓止血学会学術集会
  • Place of Presentation: 奈良市・奈良春日野国際フォーラム甍
• [Patent(Industrial Property Rights)] せん断応力負荷時のフォンウィルブランド因子高分子マルチマーの保持率のインビトロ測定法 (2017)
  • Inventor(s): 坂爪公、堀内久徳、齋木佳克、丸山修、迫田大輔、土方亘
  • Industrial Property Rights Holder: 坂爪公、堀内久徳、齋木佳克、丸山修、迫田大輔、土方亘
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2017-186730
  • Filing Date: 2017