Application of new indole compounds to organ protection in the Cardiovascular surgery

• Project/Area Number: 15K10205
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Tohoku University
• Principal Investigator: Adachi Osamu 東北大学, 医学系研究科, 准教授 (30375092)
• Co-Investigator(Kenkyū-buntansha): 齋木 佳克 東北大学, 医学系研究科, 教授 (50372298) ; 阿部 高明 東北大学, 医工学研究科, 教授 (80292209) ; 笠井 均 東北大学, 多元物質科学研究所, 教授 (30312680)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: インドール化合物 / 脊髄保護 / 心移植 / ミトコンドリア / ATP / 虚血再灌流障害 / 虚血再灌流 / 心臓移植

Outline of Final Research Achievements

The new indole compound has depression effect for the ischemic reperfusion injury of the brain and kidney.We examined efficacy for the organ protection in the cardiovascular surgery region.Spinal cord injury is a serious complication in the replacement of the thoracoabdominal artery.In the perioperative spinal cord blood hypoperfusion model using the rabbit, the spinal ischemic reperfusion depression effect was not found.We evaluated a donor cardioprotection effect in the heart transplant. We examined a change of the quantity of rat myocardial ATP by the elapsed time from heart extraction. The myocardial ATP content decreased equally with a non-administration group two hours after the heart extraction. In these examination, we were not able to demonstrate spinal cord and myocardial protection effect.