Lanthanum carbonate inhibits aortic allograft calcification in circulatory transplant models
| Project/Area Number |
15K10207
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Yamauchi Haruo 東京大学, 医学部附属病院, 講師 (60726735)
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| Co-Investigator(Kenkyū-buntansha) |
小野 稔 東京大学, 医学部附属病院, 教授 (40270871)
木下 修 東京大学, 医学部附属病院, 特任講師 (40598512)
益澤 明広 東京大学, 医学部附属病院, 特任講師 (30709572)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 同種心臓弁・血管移植 / 石灰化 / リン酸バインダー / 移植グラフト石灰化 / 炭酸ランタン / リンバインダー / 若年齢レシピエント / ホモグラフト / 高リン血症 / ウサギ |
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| Outline of Final Research Achievements |
<OBJECTIVES> Limited durability of a cardiovascular homograft due to accelerated calcification in young recipients is an unsolved problem. We hypothesized that phosphate binder, lanthanum carbonate (LC) inhibits calcification of a transplanted homograft, and examine this hypothesis by circulatory transplant rabbit model. <METHODS> Donor aortas were transplanted to carotid arteries of recipients. All the recipients were euthanized after 8 weeks and the homograft were explanted. LC group rabbits were fed by a diet containing LC for 1, 2, 4, 8 weeks postoperatively followed by feeding normal diets. The results were compared with those from control group rabbits which were fed by a normal diet. <RESULTS> Homograft calcification was inhibited in the LC group by giving LC for at least 2 weeks, but growth retardation was seen in the rabbits with LC for 8 weeks. <CONCLUSIONS> Short-term LC may safely inhibit aortic homograft calcification without significant side effects.
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Report
(4 results)
Research Products
(3 results)
