Metabolic profiling of reverse remodeling and cardiac recovery in end-stage congestive hart failure
Project/Area Number |
15K10213
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular surgery
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Research Institution | International University of Health and Welfare (2016-2018) Osaka University (2015) |
Principal Investigator |
Nakamura Teruya 国際医療福祉大学, 医学部, 主任教授 (90511626)
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Co-Investigator(Kenkyū-buntansha) |
上野 高義 大阪大学, 医学系研究科, 講師 (60437316)
吉川 泰司 大阪大学, 医学系研究科, 寄附講座准教授 (40570594)
宮川 繁 大阪大学, 医学系研究科, 特任教授(常勤) (70544237)
|
Research Collaborator |
MATSUNAGA Yuriko
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Project Period (FY) |
2015-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 心不全 / reverse remodeling / メタボロミクス / 拡張型心筋症 / 補助人工心臓 / バイオマーカー / リモデリング / メタボローム解析 / リバース・リモデリング / メタボロミックス / Reverse remodeling |
Outline of Final Research Achievements |
In this project, we examined the change in metabolic profiles using systematic analysis of metabolites in patients with dilated cardiomyopathy (DCM) that required left ventricular assist device (LVAD). Energy metabolites such as ones in TCA cycle and beta-oxidation are increased compared to normal, and the increased metabolites decreased to normal levels several weeks after LVAD insertion. In contrast, sex hormone metabolites and biomarkers of depression were low in DCM patients, and these did not change after LVAD insertion. These findings demonstrated that the energy metabolic profiles in patients with DCM were changed drastically by ventricular unload, supporting, at least in part, the biochemical mechanisms of reverse remodeling of the ventricle in patients with end-stage heart failure.
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Academic Significance and Societal Importance of the Research Achievements |
拡張型心筋症などによる重症心不全の発症メカニズムの多くは不明であり新たな研究手法として、メタボローム解析(メタボロミクス)が注目されている。本研究では、拡張型心筋症を代表とした心不全患者には特徴的な代謝パターン、特にエネルギー代謝、ミトコンドリア機能や性機能などの障害が認められ、一部は治療介入により正常化することを明らかにした。これらの結果はメタボロミクスによる代謝産物プロファイリングが重症心不全の発症メカニズム、治療効果判定(バイオマーカー)および新たな治療法の解明の一助となる可能性をもたらした。
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Report
(5 results)
Research Products
(17 results)
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[Journal Article] Rescuing Patients With Severe Biventricular Failure in the Era of Continuous-Flow Left Ventricular Assist Device2019
Author(s)
Saito S, Toda K, Nakamura T, Miyagawa S, Yoshikawa Y, Hata H, Yoshioka D, Kainuma S, Yoshida S, Sawa Y.
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Journal Title
Circulation Journal
Volume: 83
Issue: 2
Pages: 379-385
DOI
NAID
ISSN
1346-9843, 1347-4820
Year and Date
2019-01-25
Related Report
Peer Reviewed
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[Journal Article] Pioglitazone strengthen therapeutic effect of adipose-derived regenerative cells against ischemic cardiomyopathy through enhanced expression of adiponectin and modulation of macrophage phenotype.2019
Author(s)
Mori D, Miyagawa S, Matsuura R, Sougawa N, Fukushima S, Ueno T, Toda K, Kuratani T, Tomita K, Maeda N, Shimomura I, Sawa Y.
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Journal Title
Cardiovasc Diabetol.
Volume: 18
Issue: 1
Pages: 39-39
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical Results, Adverse Events, and Change in End-Organ Function in Elderly Patients With HeartMateII Left Ventricular Assist Device ― Japanese Multicenter Study ―2018
Author(s)
Yoshioka D, Toda K, Ono M, Nakatani T, Shiose A, Matsui Y, Yamazaki K, Saiki Y, Usui A, Niinami H, Matsumiya G, Arai H, Sawa Y; Japanese HeartMateII Investigators.
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Journal Title
Circulation Journal
Volume: 82
Issue: 2
Pages: 409-418
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed
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[Journal Article] Diagnosis, medical treatment, and stepwise mechanical circulatory support for fulminat myocarditis.2018
Author(s)
Saito S, Toda K, Miyagawa S, Yoshikawa Y, Hata H, Yoshioka D, Domae K, Tsukamoto Y, Sakata Y, Sawa Y.
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Journal Title
J Artif Organs.
Volume: 21
Issue: 2
Pages: 172-179
DOI
Related Report
Peer Reviewed
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[Journal Article] Diabetes mellitus impairs left ventricular mass regression after surgical or transcatheter aortic valve replacement for severe aortic stenosis2016
Author(s)
Nakamura T, Toda K, Kuratani T, Miyagawa S, Yoshikawa Y, Fukushima S, Saito S, Yoshioka D, Kashiyama N, Daimon T, Sawa Y
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Journal Title
Heart, Lung and Circulation
Volume: 25
Issue: 1
Pages: 68-74
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] B-type natriuretic peptide response and reverse left ventricular remodeling after surgical correction of functional mitral regurgitation in patients with advanced cardiomyopathy.2015
Author(s)
Kainuma S, Taniguchi K, Toda K, Shudo Y, Takeda K, Funatsu T, Miyagawa S, Kondoh H, Nishi H, Yoshikawa Y, Fukushima S, Hamada S, Kubo K, Daimon T, Sawa Y.
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Journal Title
J Cardiol
Volume: 66
Issue: 4
Pages: 279-285
DOI
Related Report
Peer Reviewed
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