Overcoming ischemic cardiomyopathy by angiogenic drugs

• Project/Area Number: 15K10214
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Osaka University
• Principal Investigator: Ueno Takayoshi 大阪大学, 医学系研究科, 寄附講座准教授 (60437316)
• Co-Investigator(Kenkyū-buntansha): 宮川 繁 大阪大学, 医学系研究科, 特任教授(常勤) (70544237) ; 福嶌 五月 国立研究開発法人国立循環器病研究センター, 病院, 医長 (80596867) ; 秦 広樹 大阪大学, 医学系研究科, 講師 (80638198)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 心筋再生 / プロスタサイクリン作動薬 / 有茎大網 / 心筋血流量 / 心筋血管抵抗 / 血管新生 / 局所心機能の改善 / 局所心筋血流量の改善 / 微小循環障害の改善

Outline of Final Research Achievements

We hypothesized that therapeutic efficacy may be augmented by a combination of placing a sheet immersed in ONO-1301SR, a slow-release synthetic prostacyclin agonist-inducing multiproangiogenic cytokines, over the left ventricle and a pedicled omental flap in a chronic myocardial infarct heart.
In conclusions,ONO-1301SR combined with a pedicled omental flap therapy synergistically promoted myocardial angiogenesis,leading to cardiac functional recovery in a porcine chronic MI model.This cell-free combination therapy shows promise as an effective treatment for enhancement of myocardial angiogenesis in a chronic MI heart．

Research Products

• [Journal Article] A prostacyclin agonist and an omental flap increased myocardial blood flow in a porcine chronic ischemia model. (2018)
  • Author(s): Yajima , Miyagawa , Fukushima , Sakai Y, Isohashi , Watabe , Ikeda , Horitsugi G, Harada A, Sakaniwa R, Hatazawa J, Sawa Y
  • Journal Title: Journal of Thorac Cardiovasc Surgery Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] ミニブタ虚血性心筋症モデルを用いた徐放性プロスタサイクリンアゴニスト”ONO1301-SR”と有茎大網を用いた心筋再生療法の開発 (2016)
  • Author(s): 矢嶋真心
  • Journal Title: 日本心臓血管外科学会雑誌 Volume: 45 Pages: 18-23
• [Journal Article] A sustained-release drug-delivery system of synthetic prostacyclin agonist, ONO-1301SR: a new reagent to enhance cardiac tissue salvage and/or regeneration in the damager heart (2015)
  • Author(s): Fukushima S Miyagawa S, Sakai Y, Sawa Y
  • Journal Title: Heart Fail Rev Volume: 20 Issue: 4 Pages: 401-13
  • DOI: 10.1007/s10741-015-9477-8
• [Presentation] A Slow-Release Synthetic Prostacyclin Agonist “YS1402” Combined with Pedicle Omental Flap Reduces Microvascular Resistance and Increases Myocardial Blood Flow, Associated with Functional Recovery, in a Porcine Chronic Myocardial Infarction Model (2016)
  • Author(s): Shin Yajima
  • Organizer: AHA 2016
  • Place of Presentation: NewOrleans, USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] A Slow-Releasing Synthetic Prostacyclin Agonist “ONO 1301-SR” Combined with Omental Flap Increases Myocardial Blood Flow and Reduces Microvascular Resistance, Associated with Functional Recovery, in a Porcine Chronic Myocardial Infarction Model (2016)
  • Author(s): Shin Yajima
  • Organizer: BSCR Autumn Metting 2016
  • Place of Presentation: Leeds, UK
  • Year and Date: 2016-09-05
  • Int'l Joint Research / Invited
• [Presentation] 虚血性重症心不全に対するプロスタサイクリンアゴニストを用いたセルフリー型心筋再生療法の開発 (2016)
  • Author(s): 矢嶋真心
  • Organizer: 第21回日本冠動脈外科学会
  • Place of Presentation: 電気ビル共創館（福岡市）
  • Year and Date: 2016-07-14
• [Presentation] ミニブタ虚血性心筋症モデルを用いたONO-1301と有茎大網を用いた心筋再生療法の開発 (2016)
  • Author(s): 矢嶋真心
  • Organizer: 第116回日本外科学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2016-04-14
• [Presentation] プロスタグランジンアゴニストを用いたCell-Free型再生医療の重症心不全への応用 (2015)
  • Author(s): 福嶌 五月
  • Organizer: 第42回日本臓器保存生物医学会
  • Place of Presentation: いわて県民情報交流センター
  • Year and Date: 2015-11-13
• [Presentation] Oral administration of synthetic prostacyclin agonist ONO-1301 prevents deterioration of cardiac performance by preserving cardiac structural proteins in the delta-sarcoglycan-deficient hamster: promising treatment for patients with DCM (2015)
  • Author(s): Miyagawa Shigeru
  • Organizer: American Heart Association 2015
  • Place of Presentation: ORANGE COUNTY CONVENTION CENTER USA
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] 新規プロスタサイクリンアゴニストを用いた慢性虚血心筋に対する心筋再生療法の開発 (2015)
  • Author(s): 福嶌 五月
  • Organizer: 第20回日本冠動脈外科学会
  • Place of Presentation: ウエスティン都ホテル京都
  • Year and Date: 2015-07-09