| Project/Area Number |
15K10214
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Osaka University |
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Principal Investigator |
Ueno Takayoshi 大阪大学, 医学系研究科, 寄附講座准教授 (60437316)
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| Co-Investigator(Kenkyū-buntansha) |
宮川 繁 大阪大学, 医学系研究科, 特任教授(常勤) (70544237)
福嶌 五月 国立研究開発法人国立循環器病研究センター, 病院, 医長 (80596867)
秦 広樹 大阪大学, 医学系研究科, 講師 (80638198)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 心筋再生 / プロスタサイクリン作動薬 / 有茎大網 / 心筋血流量 / 心筋血管抵抗 / 血管新生 / 局所心機能の改善 / 局所心筋血流量の改善 / 微小循環障害の改善 |
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| Outline of Final Research Achievements |
We hypothesized that therapeutic efficacy may be augmented by a combination of placing a sheet immersed in ONO-1301SR, a slow-release synthetic prostacyclin agonist-inducing multiproangiogenic cytokines, over the left ventricle and a pedicled omental flap in a chronic myocardial infarct heart.
In conclusions,ONO-1301SR combined with a pedicled omental flap therapy synergistically promoted myocardial angiogenesis,leading to cardiac functional recovery in a porcine chronic MI model.This cell-free combination therapy shows promise as an effective treatment for enhancement of myocardial angiogenesis in a chronic MI heart．
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