Activated cardiosphere-derived cell sheet therapy improves left ventricular function of old infarcted heart
| Project/Area Number |
15K10218
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
MIKAMO Akihito 山口大学, 大学院医学系研究科, 准教授 (30372709)
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| Co-Investigator(Kenkyū-buntansha) |
濱野 公一 山口大学, 大学院医学系研究科, 教授 (60263787)
藏澄 宏之 山口大学, 医学部, 特別医学研究員 (50645116)
細山 徹 山口大学, 医学(系)研究科(研究院), 助教 (20638803)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 再生医療 / 細胞移植 / 心筋幹細胞 / 細胞シート / 幹細胞老化 / 低酸素プレコンディショニング / 虚血性心疾患 |
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| Outline of Final Research Achievements |
We investigated the effect of cardiac stem cell (Cardiosphere-derived cells: CDCs) sheet using the hypoxic preconditioning (HPC) on the mouse old myocardial infarction model. The CDCs sheet was suggested to have a paracrine effect via the production of growth factors including VEGF. The paracrine effect resulted in an increase in angiogenesis in the border area of myocardial infarction.This effect also show the improvement of the wall motion of the mice hearts in echocardiography, and the reduction effect of the infarct region.
The effect of CDCs sheet treatment was enhanced by HPC. The HPC can easily activate the CDCs sheet function, suggesting the possibility that CDCs sheet treatment with HPC may be effective for ischemic heart disease.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Cardiosphere-derived cell sheet primed with hypoxia improves left ventricular function of chronically infarcted heart.2015
Author(s)
Hosoyama T, Samura M, Kudo T, Nishimoto A, Ueno K, Murata T, Ohama T, Sato K, Mikamo A, Yoshimura K, Li TS, Hamano K.
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Journal Title
American Journal of Translational Research
Volume: 7
Pages: 2738-2738
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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