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Myocardial regenerative therapy by stem cell transplantation with actin-organizing protein Fhod3

Research Project

Project/Area Number 15K10219
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionKyushu University

Principal Investigator

Tatewaki Hideki  九州大学, 大学病院, 講師 (40343321)

Co-Investigator(Kenkyū-buntansha) 大石 恭久  九州大学, 大学病院, 助教 (20529870)
藤本 智子  九州大学, 大学病院, その他(移行) (40567377)
牛島 智基  九州大学, 大学病院, 助教 (70529875)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords心不全 / 心筋疾患 / サルコメア / 分子生物学 / 心筋疾患外科学 / Fhod3
Outline of Final Research Achievements

At the embryonic stage, Fhod3 is crucial of cardiac development and achievement of myofibril maturation. The cardiac-specific deletion of Fhod3 in the perinatal stage leads to neonatal lethality, indicating that Fhod3 is essential to myocardial maturation in the normally developed heart.
On the other hand, its specific deletion in the adult heart does not significantly affect the survival. Moreover, the biological response for systemic stimulation with the α1-adrenergic receptor agonist increases more in adult Fhod3-deleted mice, indicating that Fhod3 is associated with functional maintenance of the adult heart.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2018 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] The actin-organizing formin protein Fhod3 is required for postnatal development and functional maintenance of the adult heart in mice.2018

    • Author(s)
      Ushijima T, Fujimoto N, Matsuyama S, Kan-O M, Kiyonari H, Shioi G, Kage Y, Yamasaki S, Takeya R, Sumimoto H.
    • Journal Title

      J Biol Chem.

      Volume: 293 Issue: 1 Pages: 148-162

    • DOI

      10.1074/jbc.m117.813931

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transgenic Expression of the Formin Protein Fhod3 Selectively in the Embryonic Heart: Role of Actin-Binding Activity of Fhod3 and Its Sarcomeric Localization during Myofibrillogenesis2016

    • Author(s)
      藤本 智子
    • Journal Title

      PLoS ONE.

      Volume: 11 Issue: 2 Pages: e0148472

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] アクチン重合制御因子Fhod3が心発生および心機能維持に果たす役割の解析2017

    • Author(s)
      牛島智基、藤本智子、神尾明君、武谷立、住本英樹、塩瀬明
    • Organizer
      第121回日本循環器学会九州地方会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウス心臓の出生後発達と心機能維持におけるフォルミン蛋白質 Fhod3 の役割2017

    • Author(s)
      牛島智基、藤本智子、松山翔、神尾明君、清成寛、塩井剛、鹿毛陽子、山崎晶、武谷立、住本英樹
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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