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Tissue engineering using decellularized whole heart

Research Project

Project/Area Number 15K10223
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionKeio University (2016-2017)
The University of Tokyo (2015)

Principal Investigator

Kitahara Hiroto  慶應義塾大学, 医学部(信濃町), 助教 (70594729)

Co-Investigator(Kenkyū-buntansha) 岡本 一真  国立研究開発法人国立成育医療研究センター, 細胞医療研究部, 共同研究員 (10338064)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords脱細胞化 / 心臓 / 再細胞化 / 心筋再生 / 心臓移植 / 補助人工心臓 / 重症心不全
Outline of Final Research Achievements

Our goal is to create a whole beating heart fabricated on an organ scaffold for human heart transplantation. We successfully performed the first heterotopic transplantation of a decellularized whole porcine heart with mesenchymal stem cells. The porcine heart was harvested following cardiac arrest induced by a high-potassium solution and stored at -80℃ for 24 hours. The porcine heart was completely decellularized and sterilized with gamma irradiation. Cultured mesenchymal stem cells were collected and either infused into the ascending aorta or injected directly into the left ventricular wall. Finally, recellularized whole-heart scaffolds were transplanted into pigs under systemic anti-coagulation treatment with heparin. Coronary artery angiography of the transplanted heart graft was performed. The scaffolds endured surgical procedures, and we detected short-term coronary artery perfusion in the transplanted scaffolds by angiography.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (59 results)

All 2018 2017 2016 2015

All Journal Article (25 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 21 results,  Open Access: 10 results,  Acknowledgement Compliant: 1 results) Presentation (34 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Does Robotic Beating Heart Connector Totally Endoscopic Coronary Artery Bypass Bridge the Gender Gap in Coronary Bypass Surgery?2018

    • Author(s)
      Kitahara Hiroto、McCrorey Mackenzie、Patel Brooke、Nisivaco Sarah、Balkhy Husam H.
    • Journal Title

      Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery

      Volume: 13 Issue: 1 Pages: 35-39

    • DOI

      10.1097/imi.0000000000000465

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Is robotic beating heart totally endoscopic coronary artery bypass feasible for BMI > 35 morbidly obese patients?2018

    • Author(s)
      Kitahara Hiroto、Patel Brooke、McCrorey Mackenzie、Nisivaco Sarah、Balkhy Husam H.
    • Journal Title

      The International Journal of Medical Robotics and Computer Assisted Surgery

      Volume: epub Issue: 4

    • DOI

      10.1002/rcs.1911

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Morbid Obesity Does not Increase Morbidity or Mortality in Robotic Cardiac Surgery2017

    • Author(s)
      Kitahara Hiroto、Patel Brooke、McCrorey Mackenzie、Nisivaco Sarah、Balkhy Husam H.
    • Journal Title

      Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery

      Volume: 12 Issue: 6 Pages: 434-439

    • DOI

      10.1097/imi.0000000000000435

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Extracorporeal membrane oxygenation therapy for postcardiotomy cardiogenic shock2017

    • Author(s)
      Kitahara Hiroto、Ota Takeyoshi
    • Journal Title

      The Journal of Thoracic and Cardiovascular Surgery

      Volume: 154 Issue: 2 Pages: 478-479

    • DOI

      10.1016/j.jtcvs.2017.03.065

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Left ventricular assist device explant versus decommission for myocardial recovery2017

    • Author(s)
      Kitahara Hiroto、Ota Takeyoshi
    • Journal Title

      The Journal of Thoracic and Cardiovascular Surgery

      Volume: 154 Issue: 1 Pages: 171-172

    • DOI

      10.1016/j.jtcvs.2017.03.123

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cerebral circulation estimated by laser speckle flowgraphy in2017

    • Author(s)
      Hiroto Kitaharaa
    • Journal Title

      Interactive CardioVascular and Thoracic Surgery

      Volume: 印刷中 Issue: 1 Pages: 25-29

    • DOI

      10.1093/icvts/ivx046

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bow Hunter syndrome elicited by vertebral arterial occlusion after total arch replacement.2017

    • Author(s)
      Kitahara H, Takeda T, Akasaka K, Kamiya H.
    • Journal Title

      Interact Cardiovasc Thorac Surg.

      Volume: 印刷中 Issue: 5 Pages: 806-808

    • DOI

      10.1093/icvts/ivw445

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pregnancy suppresses neuropathic pain induced by chronic constriction injury in rats through the inhibition of TNF-α.2017

    • Author(s)
      Onodera Y, Kanao-Kanda M, Kanda H, Sasakawa T, Iwasaki H, Kunisawa T.
    • Journal Title

      J Pain Res.

      Volume: 8 Issue: 3 Pages: 567-574

    • DOI

      10.1007/s10047-017-0951-z

    • NAID

      120006401530

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Implantation of a Left Ventricular Assist Device for Danon Cardiomyopathy2017

    • Author(s)
      Kitahara Hiroto、Nawata Kan、Kinoshita Osamu、Itoda Yoshifumi、Shintani Yukako、Fukayama Masashi、Ono Minoru
    • Journal Title

      The Annals of Thoracic Surgery

      Volume: 103 Issue: 1 Pages: e39-e41

    • DOI

      10.1016/j.athoracsur.2016.07.022

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] MICS僧帽弁手術における右胸壁機器配置のコツ2017

    • Author(s)
      岡本一真
    • Journal Title

      胸部外科

      Volume: 70(3) Pages: 175-175

    • Related Report
      2016 Research-status Report
  • [Journal Article] delayed splenic rupture after transcatheter arterial embolization required total splenectomy in a patient with an implantable left ventricular assist device.2016

    • Author(s)
      Kitahara H, Nawata K, Kinoshita O, Itoda Y, Kimura M, Yamauchi H, Ono M
    • Journal Title

      J Artif Organs

      Volume: 19(4) Pages: 392-395

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Modified transiliac artery approach for transcatheter aortic valve implantation. [Epub ahead of print]2016

    • Author(s)
      Kitahara H, Yoshitake A, Okamoto K, Hayashida K, Fukuda K, Shimizu H
    • Journal Title

      Cardiovasc Interv Ther

      Volume: 32(2) Pages: 196-198

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Palliative Mitral Valve Repair During Infancy for Neonatal Marfan Syndrome.2016

    • Author(s)
      Kitahara H, Aeba R, Takaki H, Shimizu H
    • Journal Title

      Ann Thorac Surg

      Volume: 101(5) Pages: 1987-8

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Heterotopic transplantation of a decellularized and recellularized whole porcine heart.2016

    • Author(s)
      Kitahara H, Yagi H, Tajima K, Okamoto K, Yoshitake A, Kashima I, Hirano A, Kasai M, Akamatsu Y, Oka H, Kitagawa Y, Shimizu H
    • Journal Title

      Interact Cardiovasc Thorac Surg

      Volume: - Issue: 5 Pages: 571-9

    • DOI

      10.1093/icvts/ivw022

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preservation of mobility of the posterior mitral leaflet after mitral valve repair with neochordae using loop technique.2016

    • Author(s)
      Kitahara H, Murata M, Okamoto K, Kudo M, Yoshitake A, Tsuruta H, Itabashi Y, Fukuda K, Yozu R, Shimizu H
    • Journal Title

      Circ J

      Volume: 80(3) Pages: 663-667

    • NAID

      130005128494

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Kinked Graft and Anastomotic Stenosis-Induced Hemolytic Anemia Requiring Reoperation2016

    • Author(s)
      Kitahara H, Yoshitake A, Hachiya T, Okamoto K, Kawaguchi S, Shimizu H
    • Journal Title

      Ann Vasc Surg

      Volume: 30(308) Pages: 308.e1-308.e4

    • DOI

      10.1016/j.avsg.2015.07.027

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 右小開胸による直視下僧帽弁手術手術2016

    • Author(s)
      岡本一真
    • Journal Title

      胸部外科

      Volume: 69(8) Pages: 603-606

    • Related Report
      2016 Research-status Report
  • [Journal Article] 右小開胸僧帽弁手術における再膨張性肺水腫の発症機序とその治療法2016

    • Author(s)
      岡本一真
    • Journal Title

      日本医事新報

      Volume: 4835 Pages: 53-54

    • Related Report
      2016 Research-status Report
  • [Journal Article] Reply2016

    • Author(s)
      Okamoto K,Arai S,Hirabayashi N,Morita M,Yozu R and ShimizuH
    • Journal Title

      The Annals of thoracic surgery

      Volume: 101 Pages: 1632-1633

    • Related Report
      2016 Research-status Report
  • [Journal Article] Hybrid Thoracic Endovascular Aortic Repair for Intercostal Patch Aneurysm after Thoracoabdominal Aortic Replacement2015

    • Author(s)
      Kitahara H, Yoshitake A, Hachiya T, Okamoto K, Hirano A, Kasai M, Akamatsu Y, Oka H, Shimizu H
    • Journal Title

      Annals of Vascular Diseases

      Volume: 8 Issue: 4 Pages: 340-342

    • DOI

      10.3400/avd.cr.15-00108

    • NAID

      130005117307

    • ISSN
      1881-641X, 1881-6428
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alternative peripheral perfusion strategies for safe cardiopulmonary bypass in atrial septal defect closure via a right minithoracotomy approach.2015

    • Author(s)
      Kitahara H, Okamoto K, Kudo M, Yoshitake A, Takahito Ito, Hayashi K, Inaba Y, Akamatsu Y, Shimizu H
    • Journal Title

      Gen Thorac Cardiovasc Surg

      Volume: - Issue: 3 Pages: 131-137

    • DOI

      10.1007/s11748-015-0611-2

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful management of severe unilateral re-expansion pulmonary edema after mitral valve repair with mini-thoracotomy using extracorporeal membrane oxygenation.2015

    • Author(s)
      Kitahara H, Okamoto K, Kudo M, Yoshitake A, Hayashi K, Inaba Y, Ai K, Suzuki T, Morisaki H, Shimizu H
    • Journal Title

      Gen Thorac Cardiovasc Surg

      Volume: - Issue: 3 Pages: 1-3

    • DOI

      10.1007/s11748-015-0592-1

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Emergency Endovascular graft repair of computed tomography-detected disruption of bilateral aorto-bi-iliac graft legs.2015

    • Author(s)
      Kitahara H, Yoshitake A, Hachiya T, Shimizu H
    • Journal Title

      Interact Cardiovasc Thorac Surg

      Volume: 21(3) Issue: 3 Pages: 391-2

    • DOI

      10.1093/icvts/ivv152

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Management of Aortic Replacement-Induced Chylothorax by Lipiodol Lymphography2015

    • Author(s)
      Kitahara H, Yoshitake A, Hachiya T, Inaba Y, Tamura K, Yashiro H, Nakatsuka S, Shimizu H
    • Journal Title

      Annals of Vascular Diseases

      Volume: 8 Issue: 2 Pages: 110-112

    • DOI

      10.3400/avd.cr.15-00002

    • NAID

      130005084193

    • ISSN
      1881-641X, 1881-6428
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Management of Right Atrial Hemangioma in a Patient with Antithrombin Deficiency.2015

    • Author(s)
      Kitahara H, Kudo M, Okamoto M, Inaba Y, Sasaki A, Shimizu H
    • Journal Title

      Ann Thorac Surg

      Volume: 99(3) Issue: 3 Pages: e53-e55

    • DOI

      10.1016/j.athoracsur.2014.12.032

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 僧帽弁両尖病変に対する僧帽弁形成術156例の中長期予後2017

    • Author(s)
      岡本一真、飯田泰功、浅原祐太、飯尾みなみ、池端幸起、平野暁教、川口新治、木村成卓、山﨑真敬、吉武明弘、饗庭了、志水秀行
    • Organizer
      第47回日本心臓血管外科学会学術総会
    • Place of Presentation
      グランドニッコー東京(東京都港区)
    • Year and Date
      2017-02-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 右小開胸僧帽弁手術における合併症回避への取り組み~18年494例の変遷から~2017

    • Author(s)
      岡本一真、飯田泰功、浅原祐太、飯尾みなみ、池端幸起、平野暁教、川口新治、木村成卓、山﨑真敬、吉武明弘、饗庭了、志水秀行
    • Organizer
      第47回日本心臓血管外科学会学術総会
    • Place of Presentation
      グランドニッコー東京(東京都港区)
    • Year and Date
      2017-02-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 植込み型補助人工心臓術後ポンプ内血栓症の危険因子と治療法の検討2017

    • Author(s)
      北原大翔
    • Organizer
      第70回 日本胸部外科学会定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Does Robotic Beating Heart Connector TECAB Bridge The Gender Gap In Coronary Bypass Surgery?2017

    • Author(s)
      北原大翔
    • Organizer
      2017 ISMICS Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Morbid Obesity Does Not Increase Morbidity or Mortality in Robotic Cardiac Surgery2017

    • Author(s)
      北原大翔
    • Organizer
      2017 ISMICS Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Subcostal Approach is Favorable Compared to Full Sternotomy for Continuous-Flow Left Ventricular Assist Device Exchange2017

    • Author(s)
      北原大翔
    • Organizer
      ISHLT 37th Annual Meeting & Scientific Sessions
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Advantage of Bridge to Transplantation With Subclavian Intra-Aortic Balloon Pump Compared to Left Ventricular Assist Device Support2017

    • Author(s)
      北原大翔
    • Organizer
      ISHLT 37th Annual Meeting & Scientific Sessions
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Device Exchange is Superior to Medical Therapy for Treating Continuous-Flow Left Ventricular Assist Device Thrombosis.2017

    • Author(s)
      北原大翔
    • Organizer
      ISHLT 37th Annual Meeting & Scientific Sessions
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Laser Speckle Flowgraphyによる大腿動脈送血中の脳血流評価2017

    • Author(s)
      北原大翔
    • Organizer
      第47回日本心臓血管外科学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Is Robotic totally endoscopic coronary artery bypass feasible for BMI > 35 morbidly obese patients?2017

    • Author(s)
      北原大翔
    • Organizer
      2017 Society of Robotic Surgery Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 複雑病変に対しても右小開胸僧帽弁形成術は標準手術である2016

    • Author(s)
      岡本一真、北原大翔、川口新治、平野暁教、河西未央、浅原祐太、飯尾みなみ、池端幸起、木村成卓、山﨑真敬、吉武明弘、饗庭了、志水秀行
    • Organizer
      第69回日本胸部外科学会定期学術集会
    • Place of Presentation
      岡山コンベンションセンター(岡山県岡山市)
    • Year and Date
      2016-09-30
    • Related Report
      2016 Research-status Report
  • [Presentation] 心房細動マネジメントにおける最近の話題2016

    • Author(s)
      岡本一真
    • Organizer
      Cardiovascular Surgery Specialist Seminar
    • Place of Presentation
      慶應義塾大学病院2号館(東京都新宿区)
    • Year and Date
      2016-08-02
    • Related Report
      2016 Research-status Report
  • [Presentation] 2016年度当科における手術症例の推移ならびに降圧管理について2016

    • Author(s)
      岡本一真
    • Organizer
      第11回信濃町Cardiovascular Surgery研究会
    • Place of Presentation
      アステラス製薬株式会社 本社別館(東京都中央区)
    • Year and Date
      2016-07-23
    • Related Report
      2016 Research-status Report
  • [Presentation] OPCAB時代に若手心臓血管外科医は冠動脈バイパスの術者になれるのか?2016

    • Author(s)
      岡本一真
    • Organizer
      第一回Harvest Club
    • Place of Presentation
      ホテル日航福岡(福岡県福岡市)
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report
  • [Presentation] TAVI vs SAVR in Intermedinte -low Risk Patients2016

    • Author(s)
      Okamoto K
    • Organizer
      SAVR in Still the Gold Standard CVIT 2016
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 外科医から見た出血のマネージメント2016

    • Author(s)
      岡本一真
    • Organizer
      Japan MICS Summit 2016
    • Place of Presentation
      ナレッジキャピタルコングレコンベンションセンター(大阪府大阪市)
    • Year and Date
      2016-07-02
    • Related Report
      2016 Research-status Report
  • [Presentation] Quantitative evaluation of endoleakage by transesophageal echocardiography during thoracic endovascular aortic repair.2016

    • Author(s)
      Kitahara H, Hashizume K, Inoue S, Neomoto A, Hayashi K, Hosoda R, Kaneyama H, Shimizu H
    • Organizer
      2016 ISMICS Annual Meeting. Canada, Montreal
    • Place of Presentation
      モントリオール(カナダ)
    • Year and Date
      2016-06-16
    • Related Report
      2016 Research-status Report
  • [Presentation] Mitral Valve Repair Thorough Minithoracotomy As a First Choice Approach2016

    • Author(s)
      Okamoto K,kudo M.Yoshitake A,Akamatsu Y,Hirano A,Kawashima T,Kasai MHirano A,Kitahara H,Kawaguchi S,Kashima I,Aeba R,Shimizu H
    • Organizer
      ISMICS Annual Scientific Meeting
    • Place of Presentation
      モントリオール(カナダ)
    • Year and Date
      2016-06-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 僧帽弁形成術・小切開心臓血管治療について2016

    • Author(s)
      岡本一真
    • Organizer
      新宿ハートカンファレンス
    • Place of Presentation
      新宿住友ホール・スカイルーム(東京都新宿区)
    • Year and Date
      2016-05-28
    • Related Report
      2016 Research-status Report
  • [Presentation] Ascending aortic repair with supra-aortic bypass for acute type A aortic dissection.2016

    • Author(s)
      Kitahara H, Hashizume K, Inoue S, Nemoto A, Hayashi K, Hosoda R, Kaneyama H, Shimizu H
    • Organizer
      The 65th International Congress of the European Society for CardioVascular and Endovascular Surgery
    • Place of Presentation
      ベオグラード(セルビア)
    • Year and Date
      2016-04-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 小切開開胸心房中隔欠損孔閉鎖術時の小口径大腿動脈に対する人工 心肺送血路確保の工夫2016

    • Author(s)
      北原大翔、岡本一真、吉武明弘、工藤樹彦、饗庭 了、川口新治、 平野暁教、河西未央、赤松雄太、岡 秀俊、志水秀行
    • Organizer
      第116回 日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 右小開胸MICSは心臓手術の標準アプローチとなり得る2016

    • Author(s)
      岡本一真、工藤樹彦、吉武明弘、赤松雄太、岡英俊、河西未央、平野暁教、北原大翔、川口新治、志水秀行
    • Organizer
      第116回 日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 僧帽弁に対する低侵襲治療の現状2016

    • Author(s)
      岡本一真、当广遼、伊集院真一、三里卓也、林太郎、山口眞弘、戸部智
    • Organizer
      医工学治療学会第33回学術大会
    • Place of Presentation
      くにびきメッセ(島根県松江市)
    • Year and Date
      2016-04-08
    • Related Report
      2016 Research-status Report
  • [Presentation] 脱細胞化技術を用いた移植心臓の作成に向けて。-ブタ脱細胞心臓の異所性移植-2015

    • Author(s)
      北原大翔、八木洋、田島一樹、岡本一真、吉武明弘、北川雄光、志水秀行
    • Organizer
      第53回 日本人工臓器学会大会
    • Place of Presentation
      東京ドームホテル(東京都文京区)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Research-status Report
  • [Presentation] 経カテーテル大動脈弁留置術と外科的大動脈弁置換術の周術期合併症の比較2015

    • Author(s)
      北原大翔、吉武明弘、岡本一真、工藤樹彦、加島一朗、饗庭了、川口新治、河西未央、赤松雄太、岡英俊、林田健太郎、八島史明、福田恵一、志水秀行
    • Organizer
      第68回 日本胸部外科学会定期学術集会
    • Place of Presentation
      神戸ポートピアホテル・神戸国際展示場1号館(神戸市中央区)
    • Year and Date
      2015-10-19
    • Related Report
      2015 Research-status Report
  • [Presentation] Loop techniqueを用いた僧帽弁形成術後の後尖の可動性温存とその治療効果の検討2015

    • Author(s)
      北原大翔、村田光繁、岡本一真、工藤樹彦、吉武明弘、饗庭了、川口新治、平野暁教、河西未央、赤松雄太、岡英俊、福田恵一、志水秀行
    • Organizer
      第68回 日本胸部外科学会定期学術集会
    • Place of Presentation
      神戸ポートピアホテル・神戸国際展示場1号館(神戸市中央区)
    • Year and Date
      2015-10-19
    • Related Report
      2015 Research-status Report
  • [Presentation] (座長) 高齢者大動脈弁狭窄症2015

    • Author(s)
      北原大翔
    • Organizer
      第68回 日本胸部外科学会定期学術集会
    • Place of Presentation
      神戸ポートピアホテル・神戸国際展示場1号館(神戸市中央区)
    • Year and Date
      2015-10-19
    • Related Report
      2015 Research-status Report
  • [Presentation] Heterotopic transplantation of decellularized heart in a large animal model2015

    • Author(s)
      Kitahara H, Yagi H, Tajima K, Inomata K, Okamoto K, Aeba R, Kudo M, Yoshitake A, Kitagawa Y, Shimizu H
    • Organizer
      The 29th EACTS Annual Meeting
    • Place of Presentation
      アムステルダム(オランダ)
    • Year and Date
      2015-10-05
    • Related Report
      2015 Research-status Report
  • [Presentation] 脱細胞化・再細胞化ブタ心臓の異所性移植2015

    • Author(s)
      北原大翔、八木 洋、田島一樹、猪股健太、岡本一真、吉武明弘、饗庭 了、工藤樹彦、島 優作、中根智美、北川雄光、志水秀行
    • Organizer
      第51回日本移植学会総会
    • Place of Presentation
      ホテル日航熊本他(熊本県熊本市)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 全脱細胞化ブタ心臓の同種異所性移植法の検討2015

    • Author(s)
      北原大翔、八木 洋、田島一樹、岡本一真、工藤樹彦、志水秀行
    • Organizer
      第63回日本心臓病学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-09-20
    • Related Report
      2015 Research-status Report
  • [Presentation] Decellularized whole porcine heart for transplantation2015

    • Author(s)
      Kitahara H, Yagi H, Tajima K, Inomata K, Okamoto K, Aeba R, Kudo M, Yoshitake A, Kitagawa Y, Shimizu H
    • Organizer
      The XLII Congress of the European Society for Artificial Organs
    • Place of Presentation
      ルーヴェン(ベルギー)
    • Year and Date
      2015-09-03
    • Related Report
      2015 Research-status Report
  • [Presentation] 大動脈モデルにおける全心臓脱細胞化法の確立2015

    • Author(s)
      北原大翔、八木 洋、田島一樹、猪股健太、岡本一真、饗庭 了、工藤樹彦、吉武明弘、島 優作、中根智美、北川雄光、志水秀行
    • Organizer
      第20回冠動脈外科学会学術大会
    • Place of Presentation
      ウェスティン都ホテル京都(京都府京都市)
    • Year and Date
      2015-07-10
    • Related Report
      2015 Research-status Report
  • [Presentation] Outcomes of Atrial Septal Defect Closure Through Mini-Thoracotomy Approach in a Single Center2015

    • Author(s)
      Kitahara H, Okamoto K, Kudo M, Yoshitake A, Kawaguchi S, Haida H, Inaba Y, Hayashi K, Shimizu H
    • Organizer
      23rd Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery
    • Place of Presentation
      香港(中国)
    • Year and Date
      2015-05-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Surgical Outcome of Concomitant Tricuspid Valve Repair with Mini-thoracotomy Approach2015

    • Author(s)
      Kitahara H, Okamoto K, Kudo M, Yoshitake A, Kawaguchi S, Haida H, Hirano A, Hayashi K, Inaba Y, Shimizu H
    • Organizer
      American Association for Thoracic Surgery Mitral Conclave 2015
    • Place of Presentation
      ニューヨーク(アメリカ)
    • Year and Date
      2015-04-23
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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