Minimally Invasive Surgery for Atrial Fibrillation Using the Double-Potential Mapping Method

• Project/Area Number: 15K10225
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Nippon Medical School
• Principal Investigator: Nitta Takashi 日本医科大学, 大学院医学研究科, 大学院教授 (40256954)
• Co-Investigator(Kenkyū-buntansha): 石井 庸介 日本医科大学, 医学部, 准教授 (10307895) ; 坂本 俊一郎 日本医科大学, 医学部, 准教授 (50398872) ; 宮城 泰雄 日本医科大学, 医学部, 講師 (00350116)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 心房細動 / 外科治療 / 伝導ブロック / 凍結凝固 / 高周波焼灼 / 電位 / マッピング

Outline of Final Research Achievements

An experimental comparison between the radiofrequency ablation and cryothermia with respect to transmural and continuous linear ablation has demonstrated that cryothermia requires a longer time to create transmural necrosis compared to radiofrequecy ablation, cryothermia is suitable for a limited area, such as atrioventricular valve annuli or the coronary sinus, confirmation of intramural necrosis is essential in the linear cryothermia of the atrial free wall, and observation only from epicardium may not be sufficient because endocardium may not be fully-ablated because of radiator effect of warm blood.

Research Products

• [Journal Article] Is it about time to forget about intravascular lead? (2018)
  • Author(s): Nitta T
  • Journal Title: J Thorac Cardiovasc Surg Volume: 155 Issue: 4 Pages: 1509-1510
  • DOI: 10.1016/j.jtcvs.2017.12.103
  • Peer Reviewed / Open Access
• [Journal Article] 心房細動の外科治療：心臓血管外科の取り組み (2017)
  • Author(s): 新田 隆
  • Journal Title: Therapeutic Research Volume: 38
• [Journal Article] 心房細動に対するメイズ手術と術後外来管理 (2017)
  • Author(s): 新田 隆
  • Journal Title: 日本医師会雑誌 Volume: 146 Pages: 1349-1352
• [Journal Article] Restoration of sinus rhythm and atrial transport function after the maze procedure: U lesion set versus box lesion set. (2016)
  • Author(s): Nitta T, Ishii Y, Fujii M, Miyagi Y, Sakamoto S, Hiromoto A, Imura H.
  • Journal Title: J Thorac Cardiovasc Surg Volume: 151 Issue: 4 Pages: 1062-1069
  • DOI: 10.1016/j.jtcvs.2015.10.108
  • Peer Reviewed
• [Presentation] Insights from Electrophysiological Findings of Atrial Tachycardia after Maze Procedure (2017)
  • Author(s): Nitta T
  • Organizer: European Association for Cardio-Thoracic Surgery
  • Int'l Joint Research
• [Presentation] Why do we need atrial mapping (2017)
  • Author(s): Nitta T
  • Organizer: AMICS2017: Minimally Invasive Cardiac Surgery and Surgical Arrhythmology
  • Int'l Joint Research / Invited
• [Presentation] Map-Guided Ablation of Non-Ischemic VT (2017)
  • Author(s): Nitta T
  • Organizer: AATS Surgical Treatment of Arrhythmias and Rhythm Disorders
  • Int'l Joint Research / Invited
• [Presentation] Surgery for LV Summit VT (2016)
  • Author(s): Nitta T, Sakamoto S, Miyagi Y, Kawase Y, Morishima M, Aoyama J, Shibata M, Ishii Y, Takahashi K, Hayashi H, Murata H, Shimizu W
  • Organizer: American Heart Association
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-14
  • Int'l Joint Research
• [Presentation] Mechanism and Prevention of Atrial Tachycardia after the Maze Procedure (2016)
  • Author(s): Nitta T
  • Organizer: APHRS 2016
  • Place of Presentation: Seoul
  • Year and Date: 2016-10-14
  • Int'l Joint Research / Invited
• [Presentation] Role of surgery for ventricular arrhythmias (2016)
  • Author(s): Nitta T
  • Organizer: APHRS Summit 2016
  • Place of Presentation: Singapore
  • Year and Date: 2016-04-02
  • Int'l Joint Research / Invited
• [Presentation] New Insight in Mapping and Ablation of AF: Surgical Mapping and Ablation of AF (2015)
  • Author(s): Nitta T
  • Organizer: Heart Rhythm
  • Place of Presentation: Boston, MA
  • Year and Date: 2015-05-14
  • Int'l Joint Research / Invited
• [Presentation] Restoration of Sinus Rhythm and Atrial Transport Function after the Maze Procedure: Box-lesion versus U-lesion Set (2015)
  • Author(s): Nitta T, Ishii Y, Fujii M, Miyagi Y, Sakamoto S, Hiromoto A, Imura H.
  • Organizer: American Association of Thoracic Surgery
  • Place of Presentation: Seattle, WA
  • Year and Date: 2015-04-29
  • Int'l Joint Research
• [Book] Interventional Cardiac Electrophysiology - A Multidisciplinary Approach (2015)
  • Author(s): Nitta T, Sakamot S.
  • Total Pages: 997
  • Publisher: Cardiotext Publishing