Basal Left Ventricular Dilatation and Reduced Contraction in Patients with Mitral Valve Prolapse can be Secondary to Annular Dilatation

Research Project

Project/Area Number	15K10226
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Cardiovascular surgery
Research Institution	University of Occupational and Environmental Health, Japan
Principal Investigator	FUKUDA Shota 産業医科大学, 医学部, 非常勤医師 (00464610)
Co-Investigator(Kenkyū-buntansha)	江藤政尚産業医科大学, 大学病院, 講師 (20419526) 高梨秀一郎公益財団法人日本心臓血圧研究振興会(臨床研究施設・研究部門), 外科医局, 副院長・主任部長 (30206776) 竹内正明産業医科大学, 大学病院, 准教授 (30236434) 尾辻豊産業医科大学, 医学部, 教授 (30264427) 馬原啓太郎公益財団法人日本心臓血圧研究振興会(臨床研究施設・研究部門), 内科医局, 医長 (40398607) 佐々木康之地方独立行政法人大阪市民病院機構大阪市立総合医療センター(臨床研究センター), 臨床研究センター, 部長 (50235280) 西村陽介産業医科大学, 大学病院, 准教授 (50301338) 阿部幸雄地方独立行政法人大阪市民病院機構大阪市立総合医療センター(臨床研究センター), 臨床研究センター, 副部長 (80748666) 安恒亨産業医科大学, 大学病院, 講師 (10336034)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	弁形成術 / 僧帽弁逸脱
Outline of Final Research Achievements	Echocardiography was performed in 30 controls and 130 patients with mitral valve (MV) prolapse (MVP). The basal value/averaged middle and apical values (B/MA ratio) of left ventricular (LV) cross-sectional area and strain were obtained. Patients with MVP showed significantly greater MV annular area (6.4±1.6 vs 3.7±0.6 cm2/m2), increased B/MA LV area ratio (2.4±0.5 vs 1.8±0.2) and reduced B/MA LV strain ratio (0.83±0.14 vs 0.96±0.09) than controls (P<0.001, respectively). Multivariable analyses identified that MV annular dilatation was independently associated with increased B/MA LV area ratio, which was associated with reduced B/MA LV strain ratio. In 35 MVP patients, B/MA LV area and strain ratio significantly altered following surgical MV plasty with annulus reduction (2.5±0.5 to 1.8±0.3 and 0.73±0.10 to 0.89±0.17, P<0.001, respectively).