| Project/Area Number |
15K10226
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
FUKUDA Shota 産業医科大学, 医学部, 非常勤医師 (00464610)
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| Co-Investigator(Kenkyū-buntansha) |
江藤 政尚 産業医科大学, 大学病院, 講師 (20419526)
高梨 秀一郎 公益財団法人日本心臓血圧研究振興会(臨床研究施設・研究部門), 外科医局, 副院長・主任部長 (30206776)
竹内 正明 産業医科大学, 大学病院, 准教授 (30236434)
尾辻 豊 産業医科大学, 医学部, 教授 (30264427)
馬原 啓太郎 公益財団法人日本心臓血圧研究振興会(臨床研究施設・研究部門), 内科医局, 医長 (40398607)
佐々木 康之 地方独立行政法人大阪市民病院機構大阪市立総合医療センター(臨床研究センター), 臨床研究センター, 部長 (50235280)
西村 陽介 産業医科大学, 大学病院, 准教授 (50301338)
阿部 幸雄 地方独立行政法人大阪市民病院機構大阪市立総合医療センター(臨床研究センター), 臨床研究センター, 副部長 (80748666)
安恒 亨 産業医科大学, 大学病院, 講師 (10336034)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 弁形成術 / 僧帽弁逸脱 |
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| Outline of Final Research Achievements |
Echocardiography was performed in 30 controls and 130 patients with mitral valve (MV) prolapse (MVP). The basal value/averaged middle and apical values (B/MA ratio) of left ventricular (LV) cross-sectional area and strain were obtained. Patients with MVP showed significantly greater MV annular area (6.4±1.6 vs 3.7±0.6 cm2/m2), increased B/MA LV area ratio (2.4±0.5 vs 1.8±0.2) and reduced B/MA LV strain ratio (0.83±0.14 vs 0.96±0.09) than controls (P<0.001, respectively). Multivariable analyses identified that MV annular dilatation was independently associated with increased B/MA LV area ratio, which was associated with reduced B/MA LV strain ratio. In 35 MVP patients, B/MA LV area and strain ratio significantly altered following surgical MV plasty with annulus reduction (2.5±0.5 to 1.8±0.3 and 0.73±0.10 to 0.89±0.17, P<0.001, respectively).
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