Control of bleeding tendency in thoracic aortic surgery - Toward safer surgery -

• Project/Area Number: 15K10230
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Asahikawa Medical College
• Principal Investigator: Hiroyuki Kamiya 旭川医科大学, 医学部, 教授 (30436836)
• Co-Investigator(Kenkyū-buntansha): 木村 文昭 旭川医科大学, 医学部, 助教 (20516413)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 低体温循環停止 / 凝固因子異常 / トロンボエラストメトリー / 輸血 / 胸部大動脈外科 / 循環停止法 / 低体温 / 出血傾向 / 血液凝固能

Outline of Final Research Achievements

This study was the first in the world to evaluate the cerebral blood flow during retrograde blood delivery in minimally invasive cardiac surgery using laser speckle flow graph (LSFG), and LSFG is useful as a new cerebral circulation evaluation device There was a possibility shown. No change was observed in the fundus flow inside the fundus after starting the artificial heart lung during the operation and after the cardiac arrest. Measurement during surgery by LSFG was also very simple and immediate. In order to study usefulness, it is necessary to investigate further accumulation of cases and correlation with postoperative cerebrovascular complications.

Research Products

• [Journal Article] Cerebral Hypoxia Caused by Flow Confliction During Minimally Invasive Cardiac Surgery With Retrograde Perfusion: A Word of Caution. (2017)
  • Author(s): Kanda H, Kunisawa T, Kitahara H, Iida T, Toyama Y, Kanao-Kanda M, Mori C, Kamiya H.
  • Journal Title: J Cardiothorac Vasc Anesth. 2017 Oct 6 Volume: Oct 6 Issue: 4 Pages: 1-3
  • DOI: 10.1053/j.jvca.2017.10.007
  • Peer Reviewed
• [Journal Article] Intra-aortic Balloon Pump Does Not Impede Cerebral Microcirculation During Central Extracorporeal Membrane Oxygenation Support: Evaluation With Laser Speckle Flowgraphy. (2017)
  • Author(s): Kanda H, Kitahara H, Toyama Y, Kanao-Kanda M, Kunisawa T, Kamiya H.
  • Journal Title: J Cardiothorac Vasc Anesth Volume: Aug;31(4 Issue: 4 Pages: e67-e68
  • DOI: 10.1053/j.jvca.2017.04.030
  • Peer Reviewed
• [Journal Article] Cerebral circulation estimated by laser speckle flowgraphy in (2017)
  • Author(s): Hiroto Kitaharaa
  • Journal Title: Interactive CardioVascular and Thoracic Surgery Volume: 印刷中 Issue: 1 Pages: 25-29
  • DOI: 10.1093/icvts/ivx046
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Bow Hunter syndrome elicited by vertebral arterial occlusion after total arch replacement. (2017)
  • Author(s): Kitahara H, Takeda T, Akasaka K, Kamiya H.
  • Journal Title: Interact Cardiovasc Thorac Surg. Volume: 印刷中 Issue: 5 Pages: 806-808
  • DOI: 10.1093/icvts/ivw445
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Combined Use of Intra-aortic Balloon Pump and Venoarterial Extracorporeal Membrane Oxygenation Support With Femoral Arterial Cannulation Impairs Cerebral Microcirculation: Evaluation With Laser Speckle Flowgraphy. (2017)
  • Author(s): Kanda H, Kimura F, Iida T, Kanao-Kanda M, Kunisawa T, Nagaoka T, Yoshida A, Kamiya H.
  • Journal Title: Journal of Cardiothoracic & Vascular Anesthesia Volume: 印刷中
• [Journal Article] Evaluation of cerebral circulation during retrograde perfusion by laser speckle flowgraphy (2016)
  • Author(s): Fumiaki Kimura
  • Journal Title: General Thoracic and Cardiovascular Surgery Volume: 印刷中 Issue: 9 Pages: 527-531
  • DOI: 10.1007/s11748-016-0727-z
  • NAID: 120006334807
  • Peer Reviewed / Open Access
• [Journal Article] Combined Use of Intra-aortic Balloon Pump and Venoarterial Extracorporeal Membrane Oxygenation Support With Femoral Arterial Cannulation Impairs Cerebral Microcirculation: Evaluation With Laser Speckle Flowgraphy (2016)
  • Author(s): Hirotsugu Kanda,
  • Journal Title: The Journal of Cardiothoracic and Vascular Anesthesia Volume: 印刷中 Issue: 3 Pages: 1021-1024
  • DOI: 10.1053/j.jvca.2016.09.012
  • Peer Reviewed
• [Journal Article] T. Three-dimensional computed tomography imaging of the mitral valve with huge vegetation. (2016)
  • Author(s): Kamiya H, Matsuda K, Sasaki T, Kunisawa
  • Journal Title: Eur J Cardiothorac Surg. Volume: 50（3） Pages: 583-583
• [Presentation] 一、心臓外科手術における包括的凝固検査を用いた周術期モニタリング (2018)
  • Author(s): 伊勢隼人、紙谷寛之、神田浩嗣、国沢卓之、河原好絵、高橋裕之、藤井聡
  • Organizer: 第12回日本血栓止血学会学術標準化委員会シンポジウム
  • Invited
• [Presentation] 一、開心術におけるインピーダンス法を用いた血小板機能評価に関する検討 (2018)
  • Author(s): 伊勢隼人、竜川貴光、中西仙太郎、石川成津矢、紙谷寛之
  • Organizer: 第48回日本心臓血管外科学会学術総会
• [Presentation] 一、Laser Speckle Flowgraphyによる大腿動脈送血中の脳血流評価 (2017)
  • Author(s): 北原 大翔1、神田 浩嗣2、国沢 卓之2、國岡 信吾1、吉田 有里1、木村 文昭1、石川 成津矢1、紙谷 寛之1
  • Organizer: 日本心臓血管外科学会
  • Place of Presentation: グランドニッコー東京
  • Year and Date: 2017-02-27
• [Presentation] トロンボエラストメトリーを用いた循環停止及び非循環停止開心術における出血量の検討 (2017)
  • Author(s): 伊勢隼人 小林大太 中西仙太郎 石川成津矢 紙谷寛之
  • Organizer: 第７０回日本胸部外科学会定期学術集会
• [Presentation] 当科における開心術後リコモジュリン使用例の検討 (2017)
  • Author(s): 伊勢隼人 森山寛也 大平成真 小林大太 中西仙太郎 石川成津矢 紙谷寛之
  • Organizer: 第107回北海道外科学会