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Development of new diagnostic method for chest malignant lesions and lymph node metastasis using photodynamic method

Research Project

Project/Area Number 15K10251
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory surgery
Research InstitutionAsahikawa Medical College

Principal Investigator

Kitada Nasahiro  旭川医科大学, 医学部, 准教授 (60332483)

Co-Investigator(Kenkyū-buntansha) 大崎 能伸  旭川医科大学, 医学部, 教授 (30191935)
佐々木 高明  旭川医科大学, 医学部, 助教 (70516997)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords胸部悪性腫瘍 / 肺癌 / 胸膜腫瘍 / 光線力学的診断 / アミノレブリン酸 / 胸膜浸潤 / 悪性胸膜中皮腫 / 転移肺腫瘍 / 肺悪性腫瘍 / 胸膜悪性腫瘍
Outline of Final Research Achievements

We have developed a new diagnostic method using the photosensitizer 5-aminolevulinic acid (5ALA) for diagnosing intrathoracic malignant lesions. When ingested exogenously, 5ALA is metabolized to a heme precursor, protoporphyrin IX, which stays in malignant cells and emits red to pink luminescence of about 630 nm. Malignant lesions on the pleural surface emitted pink autofluorescence in contrast to the green autofluorescence of the surrounding normal tissues observed by an autofluorescence imaging system. When 28 patients with primary lung cancer were examined according to the degree of pleural infiltration (pl), red fluorescence was confirmed in 100% with p11-p13 and 27.7% with p10. The latter 5 patients had been diagnosed with PL1 preoperatively or intraoperatively. This system achieved accurate localization of malignant lesions, suggesting that it may also be applicable to photodynamic therapy.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (29 results)

All 2017 2016 2015

All Journal Article (12 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 12 results,  Open Access: 12 results,  Acknowledgement Compliant: 4 results) Presentation (16 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] Activation of Src signaling mediates acquired resistance to ALK inhibition in lung cancer.2017

    • Author(s)
      Yoshida R, Sasaki T, Minami Y, Hibino Y, Okumura S, Sado M, Miyokawa N, Hayashi S, Kitada M, Ohsaki Y
    • Journal Title

      Int J Oncol. 2017; 51(5):1533-1540.

      Volume: 51 Issue: 5 Pages: 1533-1540

    • DOI

      10.3892/ijo.2017.4140

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Photodynamic diagnosis of visceral pleural invasion of lung cancer with a combination of 5-aminolevulinic acid and autofluorescence observation systems.2017

    • Author(s)
      Kitada M, Ohsaki Y, Yasuda S, Abe M, Takahashi N, Okazaki S ,Ishibashi K, Hayashi S.
    • Journal Title

      Photodiagnosis Photodyn Therpy

      Volume: 20 Pages: 10-15

    • DOI

      10.1016/j.pdpdt.2017.08.013

    • NAID

      120006491640

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinicopathological Study of Neuroendocrine Carcinoma of the Breast2017

    • Author(s)
      Masahiro Kitada, Shunsuke Yasuda, Masahiro Abe, Nana Takahashi, Satoshi Okazaki, Kei Ishibashi, Satoshi Hayashi.
    • Journal Title

      Journal of Cancer Therapy

      Volume: 8 Issue: 08 Pages: 7-7

    • DOI

      10.4236/jct.2017.88069

    • NAID

      120006491637

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Observation of Zn-photoprotoporphyrin red Autofluorescence in human bronchial cancer using color-fluorescence endoscopy2017

    • Author(s)
      Ohsaki Y, Sasaki T, Endo S, Kitada M, Okumura S, Hirai N, Kazebayashi Y, Toyoshima E, Yamamoto Y, Takeyama K, Nakajima S, Sakata I.
    • Journal Title

      BMC Cance

      Volume: 17 Issue: 1 Pages: 289-289

    • DOI

      10.1186/s12885-017-3277-6

    • NAID

      120006471088

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nodular fasciitis of the breast clinically resembling breast cancer in an elderly woman: a case report2017

    • Author(s)
      Hayashi S, Yasuda S , Takahashi N, Okazaki S, Ishibashi K, Kitada M, Miyokawa N
    • Journal Title

      J Med Case Rep

      Volume: 11(2) Issue: 1

    • DOI

      10.1186/s13256-017-1219-1

    • NAID

      120006346201

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Surgical treatment for mediastinal parathyroid adenoma causing primary hyperparathyroidism2016

    • Author(s)
      Kitada M, Yasuda S, Nana T, Ishibashi K, Hayashi S, Okazaki S
    • Journal Title

      J Cardiothorac Surg

      Volume: 11 Issue: 1

    • DOI

      10.1186/s13019-016-0461-8

    • NAID

      120006346195

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Non-islet cell tumor hypoglycemia caused by intrathoracic solitary fibrous tumor: A case report2016

    • Author(s)
      Kitada, M., Yasuda, S., Takahashi, N., Okazaki, S., Ishibashi, K., Hayashi, S., Ohsaki, Y., Miyokawa, N.
    • Journal Title

      Journal of Cardiothoracic Surgery

      Volume: 11(1) Issue: 1 Pages: 49-49

    • DOI

      10.1186/s13019-016-0463-6

    • NAID

      120006346196

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epigenetic modification augments the immunogenicity of human leukocyte antigen G serving as a tumor antigen for T cell-based immunotherapy2016

    • Author(s)
      Ishibashi K, Kumai T, Ohkuri T, Kosaka A, Nagato T, Hirata Y, Ohara K, Oikawa K, Aoki N, Akiyama N, Sado M, Kitada M, Harabuchi Y, Celis E, Kobayashi H.
    • Journal Title

      Oncoimmunology

      Volume: 5(6) Issue: 6 Pages: e1169356-e1169356

    • DOI

      10.1080/2162402x.2016.1169356

    • NAID

      120006325057

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Clinicopathological Study of Epithelial Metaplastic Breast Cancer.2016

    • Author(s)
      Masahiro Kitada, Shunsuke Yasuda, Nana Takahashi, Satoshi Okazaki, Kei Ishibashi, Satoshi Hayashi.
    • Journal Title

      Journal of Cancer Therapy

      Volume: 7 Issue: 13 Pages: 1039-1044

    • DOI

      10.4236/jct.2016.713100

    • NAID

      120006334806

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Intramedullary Spinal Cord Metastases in Breast Cancer: Report a Case2016

    • Author(s)
      Masahiro Kitada*, Nana Takahashi, Shunsuke Yasuda, Satoshi Okazaki, Kei Ishibashi, Satoshi Hayashi
    • Journal Title

      Journal of Cancer Therapy

      Volume: 7 Issue: 13 Pages: 1034-1038

    • DOI

      10.4236/jct.2016.713099

    • NAID

      120006334805

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Photodynamic diagnosis of pleural malignant lesions with a combination of 5-aminolevulinic acid and intrinsic fluorescence observation systems2015

    • Author(s)
      Masahiro Kitada,Yoshinobu Ohsaki,Yoshinari Matsuda,Satoshi Hayashi and Kei Ishibashi
    • Journal Title

      BMC Cancer

      Volume: 15 Issue: 1 Pages: 107-107

    • DOI

      10.1186/s12885-015-1194-0

    • NAID

      120005623220

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Leiomyoma of the Trachea: a case report2015

    • Author(s)
      Masahiro Kitada, Kensuke Yasuda, Kei Ishibashi, Satoshi Hayashi, Yoshinari Matuda, Yoshinobu Ohsaki and Naoyuki Miyokawa
    • Journal Title

      Journal of Cardiothoracic Surgery

      Volume: 10 Issue: 1 Pages: 78-78

    • DOI

      10.1186/s13019-015-0283-0

    • NAID

      120005646368

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 5ALA と自家蛍光観察システムを併用した胸膜悪性病変に対する光学的診断2017

    • Author(s)
      北田正博 大崎能伸
    • Organizer
      日本外科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アミノレブリン酸(5ALA)を用いた胸部悪性病変の光学的診断と低侵襲治療への展望2017

    • Author(s)
      北田正博 大崎能伸
    • Organizer
      日本呼吸器内視鏡学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アミノレブリン酸(5ALA)を用いた胸部悪性病変の光学的診断と低侵襲治療への展望2017

    • Author(s)
      北田正博 大崎能伸
    • Organizer
      日本胸部外科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 5ALA と自家蛍光観察システムを併用した肺癌胸膜浸潤に対する光線力学的診断2017

    • Author(s)
      北田正博 大崎能伸 竹山周良
    • Organizer
      日本レーザー医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 自家蛍光と5ALA を併用した胸膜悪性腫瘍に対する光線力学的診断2017

    • Author(s)
      北田正博 大崎能伸 竹山周良
    • Organizer
      日本レーザー学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 5ALAと自家蛍光観察システムを併用した2016

    • Author(s)
      北田正博、大崎能伸
    • Organizer
      第37回日本レーザー医学会
    • Place of Presentation
      旭川市
    • Year and Date
      2016-10-21
    • Related Report
      2016 Research-status Report
  • [Presentation] アミノレブリン酸と自覚蛍光観察システムを併用した胸膜悪性腫瘍に対する光学的診断2016

    • Author(s)
      北田正博、大崎能伸、安田俊輔、髙橋奈七、岡崎智、石橋佳、林諭史
    • Organizer
      第69回日本胸部外科学会定期学術集会
    • Place of Presentation
      岡山市
    • Year and Date
      2016-09-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 5ALAと自家蛍光観察システムを用いた胸膜悪性病変の光学的診断とその展望2016

    • Author(s)
      北田正博、大崎能伸
    • Organizer
      第39回日本呼吸器内視鏡学会学術集会
    • Place of Presentation
      名古屋市
    • Year and Date
      2016-06-23
    • Related Report
      2016 Research-status Report
  • [Presentation] 上大静脈合併切除置換術を伴う悪性縦隔腫瘍の手術2016

    • Author(s)
      安田俊輔、北田正博、髙橋奈七、石橋佳、林諭史
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 5ALAと自家蛍光観察システムを併用した胸膜悪性病変に対する光学的診断2016

    • Author(s)
      北田正博、大崎能伸、安田俊輔、髙橋奈七、石橋佳、林諭史
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Clinicopathological factors of breast cancer in women under 35 years:A2016

    • Author(s)
      Masahiro Kitada、Nana Takahashi, Shyunsuke Yasuda, Kei Ishibashi, Satoshi Hayashi
    • Organizer
      ICHG2016
    • Place of Presentation
      京都市
    • Year and Date
      2016-04-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 5ALAと自家蛍光観察システムを併用した胸膜悪性病変に対する光学的診断2015

    • Author(s)
      北田正博 大崎能伸
    • Organizer
      日本レーザー学会
    • Place of Presentation
      宇都宮
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 5ALAと自家蛍光観察システムを併用した胸膜悪性病変に対する光学的診断2015

    • Author(s)
      北田正博 大崎能伸
    • Organizer
      日本胸部外科学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 肺癌胸膜浸潤(pl因子)に対する肺癌pl 因子の光学的診断2015

    • Author(s)
      北田正博 大崎能伸
    • Organizer
      日本光線力学学会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 肺癌胸膜浸潤(pl因子)に対する肺癌pl 因子の光学的診断2015

    • Author(s)
      北田正博 大崎能伸
    • Organizer
      日本呼吸器内視鏡学会
    • Place of Presentation
      東京
    • Year and Date
      2015-06-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 5ALA と自家蛍光観察システムを併用した肺癌pl 因子の光学的診断2015

    • Author(s)
      北田正博 大崎能伸
    • Organizer
      日本外科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-16
    • Related Report
      2015 Research-status Report
  • [Book] 5-アミノレブリン酸の化学と医学応用2015

    • Author(s)
      北田正博 大崎能伸
    • Total Pages
      198
    • Publisher
      東京化学同人 ポルフイリン-ALA学会
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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